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Deborah J. Watson, Ph.D.

Deborah J. Watson, Ph.D.

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Adjunct Associate Professor of Neurosurgery
Department: Neurosurgery

Contact information
2421 South Street
Philadelphia, PA 19146
B.A. (Chemistry (with honor))
Mills College, 1991.
PhD (Neurobiology)
Harvard University, 1997.
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Description of Research Expertise

1. Viral vector-mediated, targeted gene delivery to the CNS
2. Use of viral vectors and neural stem cells to deliver trophic factors in the injured CNS
3. MRI monitoring of migration of transplanted neural stem cells in the mouse CNS
4. Mechanisms of migration of neural stem cells towards areas of pathology

Selected Publications

Royo N, LeBold D, Magge S, Chen HI, Hauspurg A, Cohen A, Watson DJ.: Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function. Neuroscience 148(2): 359-70, 2007.

Watson DJ, Walton R, Magnitsky S, Bulte J, Poptani H, Wolfe JH.: Structure-specific patterns of neural stem cell engraftment after transplantation in the adult mouse brain. Human Gene Therapy 17: 693-704, 2006.

Bakshi A, Shimizu S, Keck C, Cho S, LeBold D, Morales D, Plevy J, Royo N, Arenas E, Snyder E, Watson DJ*, McIntosh T.: Neural progenitor cells engineered to secrete glial-derived neurotrophic factor promote survival and neuronal differentiation of xenografted cells in traumatic brain injury. European Journal of Neuroscience 22: 2119-34, 2006 Notes: *corresponding author.

Li L.-B, Toan S, Zelenaia O, Watson DJ, Wolfe JH, Rothstein J, Robinson MB.: Regulation of astrocytic glutamate transporter expression by Akt: Evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype. Journal of Neurochemistry 97: 759-71, 2006.

Zhang C, Saatman K, Royo N, Soltesz K, Millard M, Schouten J, Motta M, Hoover R, McMillan A, Watson DJ, Lee V, Trojanowski J, McIntosh T.: Delayed transplantation of human neurons following experimental traumatic brain injury in rats: A long-term survival and behavior study. Journal of Neurotrauma 22: 1456-74, 2005.

Magnitsky S, Watson DJ, Walton R, Pickup S, Bulte J, Wolfe JH, Poptani H.: In vivo and ex vivo MRI detection of localized and disseminated neural stem cell grafts in the mouse brain. Neuroimage 26: 744-54, 2005.

Jiang K, Watson DJ, Wolfe JH.: A genetic fusion construct between the tetanus toxin C fragment and the lysosomal acid hydrolase beta-glucuronidase expresses a bi-functional protein with enhanced secretion and neuronal uptake. Journal of Neurochemistry 93: 1334-44, 2005.

Watson DJ, Passini M, Wolfe JH.: Transduction of the choroid plexus and ependyma in neonatal mouse brain by VSV-G pseudotyped lentivirus and adeno-associated virus type 5 vectors. Human Gene Therapy 16: 49-56, 2005 Notes: Cover article.

Longhi L, Watson D, Saatman K, Thompson H, Zhang C, Fujimoto S, Royo N, Castelbuono D, Raghupathi R, Trojanowski J, Lee V, Wolfe J, Stochetti N, McIntosh T.: Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice. Journal of Neurotrauma 21: 1723-36, 2004.

Susarla B, Seal R, Zelenaia O, Watson DJ, Wolfe JH, Amara S, Robinson M.: Differential regulation of GLAST immunoreactivity and activity by protein kinase C (PKC): Evidence for modification of amino and carboxyl termini. Journal of Neurochemistry 91: 1151-1163, 2004.

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Last updated: 10/11/2012
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