Deborah J. Watson, Ph.D.
Adjunct Associate Professor of Pediatrics (Human Genetics)
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Center for Applied Genomics
3615 Civic Center Blvd
Abramson Building
Philadelphia, PA 19104
Center for Applied Genomics
3615 Civic Center Blvd
Abramson Building
Philadelphia, PA 19104
Email:
djw3@mail.med.upenn.edu
djw3@mail.med.upenn.edu
Education:
B.A. (Chemistry (with honor))
Mills College, 1991.
PhD (Neurobiology)
Harvard University, 1997.
Certif. (Genomic Data Science)
Johns Hopkins University / Coursera, 2016.
B.A. (Chemistry (with honor))
Mills College, 1991.
PhD (Neurobiology)
Harvard University, 1997.
Certif. (Genomic Data Science)
Johns Hopkins University / Coursera, 2016.
Post-Graduate Training
Postdoctoral Fellow in Neurology, Center for Neurologic Disease, Brigham and Women’s Hospital, 1997-1998.
NIH Postdoctoral Fellow in Neuroscience, Children's Hospital of Philadelphia and University of Pennsylvania, 1998-2003.
Postdoctoral Fellow in Neurology, Center for Neurologic Disease, Brigham and Women’s Hospital, 1997-1998.
NIH Postdoctoral Fellow in Neuroscience, Children's Hospital of Philadelphia and University of Pennsylvania, 1998-2003.
Certifications
Collaborative Institutional Training Initiative (CITI) Basic Biomedical / Human Subjects Research, 2016.
Permanent linkCollaborative Institutional Training Initiative (CITI) Basic Biomedical / Human Subjects Research, 2016.
Description of Research Expertise
BioinformaticsMicroarrays
Next-generation sequencing
NGS
Whole genome sequencing
Ingenuity Pathway Analysis
Selected Publications
Royo N, LeBold D, Magge S, Chen HI, Hauspurg A, Cohen A, Watson DJ.: Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function. Neuroscience 148(2): 359-70, 2007.Watson DJ, Walton R, Magnitsky S, Bulte J, Poptani H, Wolfe JH.: Structure-specific patterns of neural stem cell engraftment after transplantation in the adult mouse brain. Human Gene Therapy 17(7): 693-704, Jul 2006.
Bakshi A, Shimizu S, Keck C, Cho S, LeBold D, Morales D, Plevy J, Royo N, Arenas E, Snyder E, Watson DJ*, McIntosh T.: Neural progenitor cells engineered to secrete glial-derived neurotrophic factor promote survival and neuronal differentiation of xenografted cells in traumatic brain injury. European Journal of Neuroscience 23(8): 2119-34, Apr 2006 Notes: *corresponding author.
Li L.-B, Toan S, Zelenaia O, Watson DJ, Wolfe JH, Rothstein J, Robinson MB.: Regulation of astrocytic glutamate transporter expression by Akt: Evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype. Journal of Neurochemistry 97(3): 759-71, May 2006.
Zhang C, Saatman K, Royo N, Soltesz K, Millard M, Schouten J, Motta M, Hoover R, McMillan A, Watson DJ, Lee V, Trojanowski J, McIntosh T.: Delayed transplantation of human neurons following experimental traumatic brain injury in rats: A long-term survival and behavior study. Journal of Neurotrauma 22(12): 1456-74, Dec 2005.
Magnitsky S, Watson DJ, Walton R, Pickup S, Bulte J, Wolfe JH, Poptani H.: In vivo and ex vivo MRI detection of localized and disseminated neural stem cell grafts in the mouse brain. Neuroimage 26(3): 744-54, Jul 2005.
Jiang K, Watson DJ, Wolfe JH.: A genetic fusion construct between the tetanus toxin C fragment and the lysosomal acid hydrolase beta-glucuronidase expresses a bi-functional protein with enhanced secretion and neuronal uptake. Journal of Neurochemistry 93(5): 1334-44, Jun 2005.
Watson DJ, Passini M, Wolfe JH.: Transduction of the choroid plexus and ependyma in neonatal mouse brain by VSV-G pseudotyped lentivirus and adeno-associated virus type 5 vectors. Human Gene Therapy 16(1): 49-56, 2005 Notes: Cover article.
Longhi L, Watson D, Saatman K, Thompson H, Zhang C, Fujimoto S, Royo N, Castelbuono D, Raghupathi R, Trojanowski J, Lee V, Wolfe J, Stochetti N, McIntosh T.: Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice. Journal of Neurotrauma 21(12): 1723-36, Dec 2004.
Susarla B, Seal R, Zelenaia O, Watson DJ, Wolfe JH, Amara S, Robinson M.: Differential regulation of GLAST immunoreactivity and activity by protein kinase C (PKC): Evidence for modification of amino and carboxyl termini. Journal of Neurochemistry 91(5): 1151-1163, Dec 2004.