Neurosurgery

Faculty

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Deborah J. Watson, Ph.D.

Adjunct Associate Professor of Neurosurgery
Department: Neurosurgery

Contact information
2421 South Street
Philadelphia, PA 19146
Education:
B.A. (Chemistry (with honor))
Mills College, 1991.
PhD (Neurobiology)
Harvard University, 1997.
Post-Graduate Training
Postdoctoral Fellow in Neurology, Center for Neurologic Disease, Brigham and Women’s Hospital, Boston., 1997-1998.
NIH Postdoctoral Fellow in Neuroscience, Children's Hospital of Philadelphia and University of Pennsylvania, 1998-2003.
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Description of Research Expertise

Bioinformatics
Microarrays
Next-generation sequencing
NGS
Whole genome sequencing
Ingenuity Pathway Analysis

Selected Publications

Royo N, LeBold D, Magge S, Chen HI, Hauspurg A, Cohen A, Watson DJ.: Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function. Neuroscience 148(2): 359-70, 2007.

Watson DJ, Walton R, Magnitsky S, Bulte J, Poptani H, Wolfe JH.: Structure-specific patterns of neural stem cell engraftment after transplantation in the adult mouse brain. Human Gene Therapy 17: 693-704, 2006.

Bakshi A, Shimizu S, Keck C, Cho S, LeBold D, Morales D, Plevy J, Royo N, Arenas E, Snyder E, Watson DJ*, McIntosh T.: Neural progenitor cells engineered to secrete glial-derived neurotrophic factor promote survival and neuronal differentiation of xenografted cells in traumatic brain injury. European Journal of Neuroscience 22: 2119-34, 2006 Notes: *corresponding author.

Li L.-B, Toan S, Zelenaia O, Watson DJ, Wolfe JH, Rothstein J, Robinson MB.: Regulation of astrocytic glutamate transporter expression by Akt: Evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype. Journal of Neurochemistry 97: 759-71, 2006.

Zhang C, Saatman K, Royo N, Soltesz K, Millard M, Schouten J, Motta M, Hoover R, McMillan A, Watson DJ, Lee V, Trojanowski J, McIntosh T.: Delayed transplantation of human neurons following experimental traumatic brain injury in rats: A long-term survival and behavior study. Journal of Neurotrauma 22: 1456-74, 2005.

Magnitsky S, Watson DJ, Walton R, Pickup S, Bulte J, Wolfe JH, Poptani H.: In vivo and ex vivo MRI detection of localized and disseminated neural stem cell grafts in the mouse brain. Neuroimage 26: 744-54, 2005.

Jiang K, Watson DJ, Wolfe JH.: A genetic fusion construct between the tetanus toxin C fragment and the lysosomal acid hydrolase beta-glucuronidase expresses a bi-functional protein with enhanced secretion and neuronal uptake. Journal of Neurochemistry 93: 1334-44, 2005.

Watson DJ, Passini M, Wolfe JH.: Transduction of the choroid plexus and ependyma in neonatal mouse brain by VSV-G pseudotyped lentivirus and adeno-associated virus type 5 vectors. Human Gene Therapy 16: 49-56, 2005 Notes: Cover article.

Longhi L, Watson D, Saatman K, Thompson H, Zhang C, Fujimoto S, Royo N, Castelbuono D, Raghupathi R, Trojanowski J, Lee V, Wolfe J, Stochetti N, McIntosh T.: Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice. Journal of Neurotrauma 21: 1723-36, 2004.

Susarla B, Seal R, Zelenaia O, Watson DJ, Wolfe JH, Amara S, Robinson M.: Differential regulation of GLAST immunoreactivity and activity by protein kinase C (PKC): Evidence for modification of amino and carboxyl termini. Journal of Neurochemistry 91: 1151-1163, 2004.

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Last updated: 10/20/2014
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