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Deborah J. Watson, PhDResearch Assistant Professor of Neurosurgery
Department: Neurosurgery
Contact information
371A Stemmler Hall
36th and Hamilton Walk Philadelphia, PA 19104
Office: 215-662-7931
Fax: 215-349-8157 Email: djw3@mail.med.upenn.edu
Education:
B.A. (Chemistry) Mills College, 1991. PhD (Neurobiology) Harvard University, 1997.
Post-Graduate Training
Permanent linkPostdoctoral Fellow in Neurology, Center for Neurologic Disease, Brigham and Women’s Hospital, Boston., 1997-1998. NIH Postdoctoral Fellow in Neuroscience, Children's Hospital of Philadelphia and University of Pennsylvania, 1998-2003. Description of Research Expertise1. Viral vector-mediated, targeted gene delivery to the CNS2. Use of viral vectors and neural stem cells to deliver trophic factors in the injured CNS 3. MRI monitoring of migration of transplanted neural stem cells in the mouse CNS 4. Mechanisms of migration of neural stem cells towards areas of pathology Selected PublicationsRoyo, N., D. LeBold, S. Magge, H.I. Chen, A. Hauspurg, A. Cohen, D.J. Watson: Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function. Neuroscience 148(2): 359-70, 2007.Watson, D. J., R. Walton, S. Magnitsky, J. Bulte, H. Poptani and J. H. Wolfe: Structure-specific patterns of neural stem cell engraftment after transplantation in the adult mouse brain. Human Gene Therapy 17: 693-704, 2006. Bakshi, A., S. Shimizu, C. Keck, S. Cho, D. LeBold, D. Morales, J. Plevy, N. Royo, E. Arenas, E. Snyder, D. J. Watson*, T. McIntosh: Neural progenitor cells engineered to secrete glial-derived neurotrophic factor promote survival and neuronal differentiation of xenografted cells in traumatic brain injury. European Journal of Neuroscience 22: 2119-34, 2006 Notes: *corresponding author. Li, L.-B, S. Toan, O. Zelenaia, D.J. Watson, J.Rothstein, M.B. Robinson: Regulation of astrocytic glutamate transporter expression by Akt: Evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype. Journal of Neurochemistry 97: 759-71, 2006. Zhang, C., K. Saatman, N. Royo, K. Soltesz, M. Millard, J. Schouten, M. Motta, R. Hoover, A. McMillan, D. J. Watson, V. Lee, J. Trojanowski and T. McIntosh: Delayed transplantation of human neurons following experimental traumatic brain injury in rats: A long-term survival and behavior study. Journal of Neurotrauma 22: 1456-74, 2005. Magnitsky, S., D. J. Watson, R. Walton, S. Pickup, J. Bulte, J. Wolfe and H. Poptani: Monitoring stem cell migration in the normal mouse brain by MRI. Neuroimage 26: 744-54, 2005. Jiang, K., Watson, D.J., and J. H. Wolfe: A genetic fusion construct between the tetanus toxin C fragment and the lysosomal acid hydrolase beta-glucuronidase expresses a bi-functional protein with enhanced secretion and neuronal uptake. Journal of Neurochemistry 93: 1334-44, 2005. Watson, D.J., M. Passini and J. H. Wolfe: Transduction of the choroid plexus and ependyma in neonatal mouse brain by VSV-G pseudotyped lentivirus and adeno-associated virus type 5 vectors. Human Gene Therapy 16: 49-56, 2005 Notes: Cover article. Longhi, L., D. J. Watson, K. Saatman, H. Thompson, C. Zhang, S. Fujimoto, N. Royo, D. Castelbuono, R. Raghupathi, J. Trojanowski, V. Lee, J. Wolfe, N. Stochetti and T. McIntosh: Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice. Journal of Neurotrauma 21: 1723-36, 2004. Susarla, B., R. Seal, O. Zelenaia, D. J. Watson, J. Wolfe, S. Amara and M. Robinson: Differential regulation of GLAST immunoreactivity and activity by protein kinase C (PKC): Evidence for modification of amino and carboxyl termini. Journal of Neurochemistry 91: 1151-1163, 2004.
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