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Deborah J. Watson, Ph.D.
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Adjunct Associate Professor of Pediatrics (Human Genetics)
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Department: Pediatrics
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Contact information
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Children's Hospital of Philadelphia
23 Center for Applied Genomics
1e 3615 Civic Center Blvd
34 Abramson Building
Philadelphia, PA 19104
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23 Center for Applied Genomics
1e 3615 Civic Center Blvd
34 Abramson Building
Philadelphia, PA 19104
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Email:
djw3@mail.med.upenn.edu
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djw3@mail.med.upenn.edu
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Education:
21 9 B.A. 23 (Chemistry (with honor)) c
26 Mills College, 1991.
21 8 PhD 19 (Neurobiology) c
2b Harvard University, 1997.
21 c Certif. 21 (Genomic Data Science) c
3c Johns Hopkins University / Coursera, 2016.
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21 9 B.A. 23 (Chemistry (with honor)) c
26 Mills College, 1991.
21 8 PhD 19 (Neurobiology) c
2b Harvard University, 1997.
21 c Certif. 21 (Genomic Data Science) c
3c Johns Hopkins University / Coursera, 2016.
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Post-Graduate Training
24 7d Postdoctoral Fellow in Neurology, Center for Neurologic Disease, Brigham and Women’s Hospital, 1997-1998.
24 89 NIH Postdoctoral Fellow in Neuroscience, Children's Hospital of Philadelphia and University of Pennsylvania, 1998-2003.
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24 7d Postdoctoral Fellow in Neurology, Center for Neurologic Disease, Brigham and Women’s Hospital, 1997-1998.
24 89 NIH Postdoctoral Fellow in Neuroscience, Children's Hospital of Philadelphia and University of Pennsylvania, 1998-2003.
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Certifications
28 3c Collaborative Institutional Training Initiative (CITI) 40 Basic Biomedical / Human Subjects Research, 2016.
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Permanent link28 3c Collaborative Institutional Training Initiative (CITI) 40 Basic Biomedical / Human Subjects Research, 2016.
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13 Microarrays
22 Next-generation sequencing
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1f Whole genome sequencing
21 Ingenuity Pathway Analysis
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Description of Research Expertise
1f Bioinformatics13 Microarrays
22 Next-generation sequencing
b NGS
1f Whole genome sequencing
21 Ingenuity Pathway Analysis
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123 Watson DJ, Walton R, Magnitsky S, Bulte J, Poptani H, Wolfe JH.: Structure-specific patterns of neural stem cell engraftment after transplantation in the adult mouse brain. Human Gene Therapy 17(7): 693-704, Jul 2006.
1c6 Bakshi A, Shimizu S, Keck C, Cho S, LeBold D, Morales D, Plevy J, Royo N, Arenas E, Snyder E, Watson DJ*, McIntosh T.: Neural progenitor cells engineered to secrete glial-derived neurotrophic factor promote survival and neuronal differentiation of xenografted cells in traumatic brain injury. European Journal of Neuroscience 23(8): 2119-34, Apr 2006 Notes: *corresponding author.
156 Li L.-B, Toan S, Zelenaia O, Watson DJ, Wolfe JH, Rothstein J, Robinson MB.: Regulation of astrocytic glutamate transporter expression by Akt: Evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype. Journal of Neurochemistry 97(3): 759-71, May 2006.
18f Zhang C, Saatman K, Royo N, Soltesz K, Millard M, Schouten J, Motta M, Hoover R, McMillan A, Watson DJ, Lee V, Trojanowski J, McIntosh T.: Delayed transplantation of human neurons following experimental traumatic brain injury in rats: A long-term survival and behavior study. Journal of Neurotrauma 22(12): 1456-74, Dec 2005.
123 Magnitsky S, Watson DJ, Walton R, Pickup S, Bulte J, Wolfe JH, Poptani H.: In vivo and ex vivo MRI detection of localized and disseminated neural stem cell grafts in the mouse brain. Neuroimage 26(3): 744-54, Jul 2005.
15f Jiang K, Watson DJ, Wolfe JH.: A genetic fusion construct between the tetanus toxin C fragment and the lysosomal acid hydrolase beta-glucuronidase expresses a bi-functional protein with enhanced secretion and neuronal uptake. Journal of Neurochemistry 93(5): 1334-44, Jun 2005.
139 Watson DJ, Passini M, Wolfe JH.: Transduction of the choroid plexus and ependyma in neonatal mouse brain by VSV-G pseudotyped lentivirus and adeno-associated virus type 5 vectors. Human Gene Therapy 16(1): 49-56, 2005 Notes: Cover article.
1b7 Longhi L, Watson D, Saatman K, Thompson H, Zhang C, Fujimoto S, Royo N, Castelbuono D, Raghupathi R, Trojanowski J, Lee V, Wolfe J, Stochetti N, McIntosh T.: Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice. Journal of Neurotrauma 21(12): 1723-36, Dec 2004.
15c Susarla B, Seal R, Zelenaia O, Watson DJ, Wolfe JH, Amara S, Robinson M.: Differential regulation of GLAST immunoreactivity and activity by protein kinase C (PKC): Evidence for modification of amino and carboxyl termini. Journal of Neurochemistry 91(5): 1151-1163, Dec 2004.
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Selected Publications
14d Royo N, LeBold D, Magge S, Chen HI, Hauspurg A, Cohen A, Watson DJ.: Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function. Neuroscience 148(2): 359-70, 2007.123 Watson DJ, Walton R, Magnitsky S, Bulte J, Poptani H, Wolfe JH.: Structure-specific patterns of neural stem cell engraftment after transplantation in the adult mouse brain. Human Gene Therapy 17(7): 693-704, Jul 2006.
1c6 Bakshi A, Shimizu S, Keck C, Cho S, LeBold D, Morales D, Plevy J, Royo N, Arenas E, Snyder E, Watson DJ*, McIntosh T.: Neural progenitor cells engineered to secrete glial-derived neurotrophic factor promote survival and neuronal differentiation of xenografted cells in traumatic brain injury. European Journal of Neuroscience 23(8): 2119-34, Apr 2006 Notes: *corresponding author.
156 Li L.-B, Toan S, Zelenaia O, Watson DJ, Wolfe JH, Rothstein J, Robinson MB.: Regulation of astrocytic glutamate transporter expression by Akt: Evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype. Journal of Neurochemistry 97(3): 759-71, May 2006.
18f Zhang C, Saatman K, Royo N, Soltesz K, Millard M, Schouten J, Motta M, Hoover R, McMillan A, Watson DJ, Lee V, Trojanowski J, McIntosh T.: Delayed transplantation of human neurons following experimental traumatic brain injury in rats: A long-term survival and behavior study. Journal of Neurotrauma 22(12): 1456-74, Dec 2005.
123 Magnitsky S, Watson DJ, Walton R, Pickup S, Bulte J, Wolfe JH, Poptani H.: In vivo and ex vivo MRI detection of localized and disseminated neural stem cell grafts in the mouse brain. Neuroimage 26(3): 744-54, Jul 2005.
15f Jiang K, Watson DJ, Wolfe JH.: A genetic fusion construct between the tetanus toxin C fragment and the lysosomal acid hydrolase beta-glucuronidase expresses a bi-functional protein with enhanced secretion and neuronal uptake. Journal of Neurochemistry 93(5): 1334-44, Jun 2005.
139 Watson DJ, Passini M, Wolfe JH.: Transduction of the choroid plexus and ependyma in neonatal mouse brain by VSV-G pseudotyped lentivirus and adeno-associated virus type 5 vectors. Human Gene Therapy 16(1): 49-56, 2005 Notes: Cover article.
1b7 Longhi L, Watson D, Saatman K, Thompson H, Zhang C, Fujimoto S, Royo N, Castelbuono D, Raghupathi R, Trojanowski J, Lee V, Wolfe J, Stochetti N, McIntosh T.: Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice. Journal of Neurotrauma 21(12): 1723-36, Dec 2004.
15c Susarla B, Seal R, Zelenaia O, Watson DJ, Wolfe JH, Amara S, Robinson M.: Differential regulation of GLAST immunoreactivity and activity by protein kinase C (PKC): Evidence for modification of amino and carboxyl termini. Journal of Neurochemistry 91(5): 1151-1163, Dec 2004.
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