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Qian Zhang, M.D.,Ph.D.

Qian Zhang, M.D.,Ph.D.

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Research Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
University of Pennsylvania School of Medicine
Department of Pathology & Laboratory Medicine
Stellar Chance Laboratories Building
422 Curie Blvd.
413A/Stellar Chance
Philadelphia, PA 19104
Office: 215-573-5468
Fax: 215-573-6523
Lab: 215-573-6530
Xi'an Medical University, Xian, China, 1986.
Institute for Medical Microbiology and Immunology University of Copenhagen, Copenhagen, Denmark, 2000.
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Description of Research Expertise

Lymphomas and other hematologic malignancie

the pathogenesis of lymphomas and, more specifically, on the role of aberrant signal transduction in malignant transformation of lymphocytes. The area of signal transduction in lymphomas and other hematopoietic and non-hematopoietic malignancies has far reaching basic, diagnostic, and therapeutic implications.

Selected Publications

Nagasawa, T., Zhang, Q., Raghunath, PN., Wang, HY., El-Salem, M., Szallasi, A., Marzec, M., Gimotty, P., Rook, AH., Vonderheid, EC., Odum, N., Wasik, MA: Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing. Leukemia Res. 30: 303-312, 2006.

Zhang, Q.*, Wang, HY., Woetmann, A., Raghunath, PN., Odum, N., Wasik, M.A.*: STAT3 induces transcription of DNA methyltransferase 1 (DNMT1) gene in malignant T-lymphocytes. Blood 108: 1058-1064, 2006 Notes: *corresponding author.

Zhang, Q., Wang, HY., Marzec, M., Raghunath, PN., Nagasawa, T., Wasik, MA : STAT3 and DNMT1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. Proc. Natl. Acad. Sci. USA. 102: 6948-6953, 2005.

Kasprzycka, M., Majewski, M., Wang, ZJ., Ptasznik, A., Wysocka, M., Zhang, Q., Marzec, M., Gimotty, P., Crompton, MR., Wasik, MA: Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes. Am J Pathol. 168: 1631-1641, 2006.

Zhang, Q., Wang, HY., Marzec, M. Raghunath, PN., Nagasawa, T., Wasik, MA : STAT3- and DNMT1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. International Symposium on the Biology and Immunology of Cutaneous Lymphoma. Page: A:24, 2005 Notes: Symposium booklet.

Zhang, Q., Wang, HY., Marzec, M., Raghunath, PN., Nagasawa, T., Wasik, MA: Chromatin Modification Pathways. Keystone Symposium Page: A:245, 2005.

Marzec, M., Kasprzycka, M., Ptasznik, A., Wlodarski, P., Zhang, Q., Odum, N., Wasik, MA: Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3. Lab. Invest. 85(12): 1544-54, Dec. 2005.

Zhang, Q., Raghunath, PN., Majewski, M., Carpentieri, DF., Xuen, L., Odum, N., Morrise, S., Skorski, T., Wasik, MA: Multilevel Dysregulation of STAT3 Activation in Anaplastic Lymphoma Kinase-Positive T/Null-Cell Lymphoma. J. Immunol. 168: 466-474, 2002.

Zhang, Q., Raghunath, PN., Majewski, M., Carpentieri, DF., Odum, N., Skorski, T., Wasik, MA: Multilevel dysregulation of STAT3 activation in T-cell lymphomas expressing anaplastic lymphoma kinase (ALK). Keystone Symposium on Jaks and STATs. Symposium booklet. Page: A:329, 2002.

Wang, ZY., Zhang, Q., Wilson, J., Ratajczak, MZ., Wasik, MA: Detection of protein tyrosine-kinase (PTK) gene expression pattern in normal and malignant T lymphocytes by combined PTK-specific PCR and parallel denaturing gradient gel electrophoresis (DGGE). J. Molec. Diagn. 5: 113-120, 2003.

Zhang, Q., Capocasale, R., Fox, FE., Bedian, V., Vonderheid, EC., Moore, JS., Nowell, PC., Haines, DS., Wasik, MA: Diminished expression of the type II receptor for TGF-beta in T cells from patients with Sezary Syndrome is not due to mutations in the receptor's poly-A tract: limitations of RT-PCR in cDNA sequence analysis of homopolymeric base stretches. Arch. Immunol. Ther. Exp. 50: 419-427, 2002.

Zhang, Q., Nowak, I., Vonderheid, EC., Rook, AH., Kadin, ME., Nowell, PC., Shaw, LM., Wasik., MA : Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc.Natl.Acad.Sci, USA. 93: 9148-9153, 1996.

Eriksen, KW., Kaltof, K., Mikkelsen, G., Nielsen, M., Zhang, Q., Geisler, C., Nissen, MH., Roepke, C., Wasik, MA., Odum, N: Constitutive STAT3 activation in Sezary Syndrome (SS): tyrphostin AG490 inhibits Stat3 activation, interleukin-2 receptor expression and growth of a Sezary Syndrome cell line. Leukemia 15: 787-793, 2001.

Nieborowska-Skorska, M., Slupianek, A., Xue, L., Zhang, Q., Raghunath, PN., Hoser, G., Wasik, MA., Morris, SW., Skorski, T: Role of Signal Transducer and Activator of Transcription 5 in Nucleophosmin/ Anaplastic Lymphoma Kinase-mediated Malignant Transformation of Lymphoid Cells. Cancer Res. 61: 6517-6523, 2001.

Brockdorff, JL., Woetmann, A., Mustelin, T., Kaltoft, K., Zhang, Q., Wasik, MA., Ropke, C., Odum, N: SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells. Cytokine 20: 141-147, 2002.

Paessler, M., Kossev, P., Tsai, D., Raghunath, PN., Majewski, M., Zhang, Q., Ramalingam, P., Schuster, S., Tomaszewski, J., Arber, D., Hsi, E., Wasik, MA: Expression of SHP-1 phosphatase indicates post-germinal center cell derivation of the B-cell post-transplant lymphoproliferative disorders (PTLDs). Lab. Invest. 82: 1599-1606, 2002.

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Last updated: 01/26/2015
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