Qian Zhang, M.D.,Ph.D.

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Research Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
University of Pennsylvania School of Medicine
Department of Pathology & Laboratory Medicine
Stellar Chance Laboratories Building
422 Curie Blvd.
413A/Stellar Chance
Philadelphia, PA 19104
Office: 215-573-5468
Lab: 215-573-6530
Education:
M.D.
Xi'an Medical University, Xian, China, 1986.
Ph.D.
Institute for Medical Microbiology and Immunology University of Copenhagen, Copenhagen, Denmark, 2000.
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Description of Research Expertise

Lymphomas and other hematologic malignancie

the pathogenesis of lymphomas and, more specifically, on the role of aberrant signal transduction in malignant transformation of lymphocytes. The area of signal transduction in lymphomas and other hematopoietic and non-hematopoietic malignancies has far reaching basic, diagnostic, and therapeutic implications.

Selected Publications

Zhang, Q.*, Wang, H.Y., Woetmann, A., Raghunath, P.N., Odum, N., Wasik, M.A.*: STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes. Blood. 108(3): 1058-1064, Aug. 2006 Notes: *corresponding author.

Kasprzycka, M., Majewski, M., Wang, Z.J., Ptasznik, A., Wysocka, M., Zhang, Q., Marzec, M., Gimotty, P., Crompton, M.R., Wasik, M.A.: Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes. Am. J. Pathol. 168(5): 1631-1641, May 2006.

Zhang, Q., Wang, HY., Marzec, M., Raghunath, PN., Nagasawa, T., Wasik, MA: Chromatin Modification Pathways. Keystone Symposium Page: A:245, 2005.

Marzec, M., Kasprzycka, M., Ptasznik, A., Wlodarski, P., Zhang, Q., Odum, N., Wasik, M.A.: Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3. Lab. Invest. 85(12): 1544-1554, Dec. 2005.

Zhang, Q., Raghunath, P.N., Majewski, M., Carpentieri, D.F., Xuen, L., Odum, N., Morrise, S., Skorski, T., Wasik, M.A.: Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma. J. Immunol. 168(1): 466-474, Jan 2002.

Wang, Z.Y., Zhang, Q., Wilson, J., Ratajczak, M.Z., Wasik, M.A.: Detection of protein tyrosine-kinase (PTK) gene expression pattern in normal and malignant T lymphocytes by combined PTK-specific polymerase chain reaction and parallel denaturing gradient gel electrophoresis. J. Mol. Diagn. 5(2): 113-120, May 2003.

Zhang, Q., Capocasale, R., Fox, F.E., Bedian, V., Vonderheid, E.C., Moore, J.S., Nowell, P.C., Haines, D.S., Wasik, M.A.: Diminished expression of the type II receptor for TGFbeta (TGFbetaRII) in T lymphocytes from patients with Sezary syndrome is not due to mutations in the receptor's poly-A tract: limitations of the standard RT-PCR in cDNA sequence analysis of homopolymeric base stretches. Arch. Immunol. Ther. Exp. (Warsz) 50(6): 419-427, Jun 2002.

Zhang, Q., Nowak, I., Vonderheid, E.C., Rook, A.H., Kadin, M.E., Nowell, P.C., Shaw, L.M., Wasik., M.A. : Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc Natl Acad Sci USA. 93(17): 9148-9153, Aug. 1996.

Nieborowska-Skorska, M., Slupianek, A., Xue, L., Zhang, Q., Raghunath, P.N., Hoser, G., Wasik, M.A., Morris, S.W., Skorski, T.: Role of signal transducer and activator of transcription 5 in nucleophosmin/ anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells. Cancer Res. 61(17): 6517-6523, Sep. 2001.

Brockdorff, J.L., Woetmann, A., Mustelin, T., Kaltoft, K., Zhang, Q., Wasik, M.A., Ropke, C., Odum, N.: SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells. Cytokine 20(4): 141-147, Nov. 2002.

Paessler, M., Kossev, P., Tsai, D., Raghunath, P.N., Majewski, M., Zhang, Q., Ramalingam, P., Schuster, S., Tomaszewski, J., Arber, D., Hsi, E., Wasik, M.A.: Expression of SHP-1 phosphatase indicates post-germinal center cell derivation of B-cell posttransplant lymphoproliferative disorders. Lab. Invest. 82(11): 1599-1606, Nov. 2002.

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Last updated: 01/30/2017
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