Qian Zhang, M.D.,Ph.D.
Research Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
University of Pennsylvania School of Medicine
Department of Pathology & Laboratory Medicine
266 John Morgan Building,
3620 Hamilton Walk
Philadelphia, PA 19104
Department of Pathology & Laboratory Medicine
266 John Morgan Building,
3620 Hamilton Walk
Philadelphia, PA 19104
Office: 215-573-6531
Email:
qian2@pennmedicine.upenn.edu
qian2@pennmedicine.upenn.edu
Education:
M.D.
Xi'an Medical University, Xian, China, 1986.
Ph.D.
Institute for Medical Microbiology and Immunology University of Copenhagen, Copenhagen, Denmark, 2000.
Permanent linkM.D.
Xi'an Medical University, Xian, China, 1986.
Ph.D.
Institute for Medical Microbiology and Immunology University of Copenhagen, Copenhagen, Denmark, 2000.
Description of Research Expertise
Lymphomas and other hematologic malignanciethe pathogenesis of lymphomas and, more specifically, on the role of aberrant signal transduction in malignant transformation of lymphocytes. The area of signal transduction in lymphomas and other hematopoietic and non-hematopoietic malignancies has far reaching basic, diagnostic, and therapeutic implications.
My current research is focused on T cell biology and applications of genetically-engineered T cells to the treatment of disease. Active research projects include:
1) Developing chimeric antigen receptors (CARs) for adoptive immunotherapy of cancer with enhanced function and improved safety.
2) Exploring the role of co-stimulatory signals in directing T cell metabolism and the way this metabolism affects T cell function within tumors.
Selected Publications
Zhang Q, Wang HY, Woetmann A, Raghunath PN, Odum N, Wasik, MA: STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes. Blood 108(3): 1058-1064, Aug 2006.Kasprzycka M, Majewski M, Wang ZJ, Ptasznik A, Wysocka M, Zhang Q, Marzec M, Gimotty P, Crompton MR, Wasik MA: Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes. Am J Pathol. 168(5): 1631-1641, May 2006.
Zhang Q, Wang HY, Marzec M, Raghunath PN, Nagasawa T, Wasik MA: Chromatin Modification Pathways. Keystone Symposium Page: A:245, 2005.
Marzec M, Kasprzycka M, Ptasznik A, Wlodarski P, Zhang Q, Odum N, Wasik MA: Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3. Lab Invest. 85(12): 1544-1554, Dec 2005.
Zhang Q, Raghunath PN, Majewski M, Carpentieri DF, Xuen L, Odum N, Morrise S, Skorski T, Wasik MA: Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma. J Immunol. 168(1): 466-474, Jan 2002.
Wang ZY, Zhang Q, Wilson J, Ratajczak MZ, Wasik MA: Detection of protein tyrosine-kinase (PTK) gene expression pattern in normal and malignant T lymphocytes by combined PTK-specific polymerase chain reaction and parallel denaturing gradient gel electrophoresis. J Mol Diagn. 5(2): 113-120, May 2003.
Zhang Q, Capocasale R, Fox FE, Bedian V, Vonderheid EC, Moore JS, Nowell PC, Haines DS, Wasik MA: Diminished expression of the type II receptor for TGFbeta (TGFbetaRII) in T lymphocytes from patients with Sezary syndrome is not due to mutations in the receptor's poly-A tract: limitations of the standard RT-PCR in cDNA sequence analysis of homopolymeric base stretches. Arch Immunol Ther Exp. (Warsz) 50(6): 419-427, Jun 2002.
Zhang Q, Nowak I, Vonderheid EC, Rook AH, Kadin ME, Nowell PC, Shaw LM, Wasik MA: Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc Natl Acad Sci USA. 93(17): 9148-9153, Aug 1996.
Nieborowska-Skorska M, Slupianek A, Xue L, Zhang Q, Raghunath PN, Hoser G, Wasik MA, Morris SW, Skorski T: Role of signal transducer and activator of transcription 5 in nucleophosmin/ anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells. Cancer Res. 61(17): 6517-6523, Sep 2001.
Brockdorff JL, Woetmann A, Mustelin T, Kaltoft K, Zhang Q, Wasik MA, Ropke C, Odum N: SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells. Cytokine 20(4): 141-147, Nov 2002.
Paessler M, Kossev P, Tsai D, Raghunath PN, Majewski M, Zhang Q, Ramalingam P, Schuster S, Tomaszewski J, Arber D, Hsi E, Wasik MA: Expression of SHP-1 phosphatase indicates post-germinal center cell derivation of B-cell posttransplant lymphoproliferative disorders. Lab Invest. 82(11): 1599-1606, Nov 2002.