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Roberto Dominguez, Ph.D.

Roberto Dominguez, Ph.D.

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Professor of Physiology
Department: Physiology
Graduate Group Affiliations

Contact information
Department of Physiology
Perelman School of Medicine
University of Pennsylvania
728 Clinical Research Bldg
415 Curie Blvd
Philadelphia, PA 19104-6085
Office: 215-573-4559
Fax: 215-573-2273
Education:
M.S. (Theoretical Physics & Mathematics)
Faculty of Physics, Odessa State University (former USSR), 1987.
Ph.D. (Protein Crystallography and Biochemistry)
Pasteur Institute and Paris-Sud University, Paris, France, 1996.
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Description of Research Expertise

Structural Biology of the Actin Cytoskeleton

The actin cytoskeleton plays an essential role in many cellular functions, including cell motility, vesicular trafficking and the maintenance of cell shape and polarity. To accomplish these functions, the actin cytoskeleton undergoes dynamic remodeling into various forms of structural and functional networks, such as lamellipodia, filopodia, stress fibers and focal adhesions. Remodeling of the cytoskeleton is a tightly regulated process, involving hundreds of actin-binding and signaling proteins. The main focus of the research in our laboratory is to understand the molecular basis for how protein-protein interaction networks bring together cytoskeleton scaffolding, nucleation, elongation, and signaling proteins to accomplish specific cellular functions. We use structural biology (x-ray crystallography, SAXS, FRET) and a host of biophysical-biochemical approaches (ITC, mass spectrometry, light scattering, fluorescence, etc).
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Last updated: 02/20/2014
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