Michael Chorny, PhD
Michael Chorny, PhD
Research Assistant Professor of Pediatrics
Department: Pediatrics
Contact information
The Abramson Pediatric Research Center, Suite 702G
The Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
The Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-590-3063
Email:
chorny@email.chop.edu
chorny@email.chop.edu
Education:
BPharm (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 1996.
MS (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 1997.
PhD (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 2004.
Permanent linkBPharm (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 1996.
MS (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 1997.
PhD (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 2004.
Selected Publications
M. Chorny, I. Fishbein, J.E. Tengood, R.F. Adamo, I.S. Alferiev, R.J. Levy: Site-specific gene delivery to stented arteries using magnetically guided zinc oleate-based nanoparticles loaded with adenoviral vectors. The FASEB Journal Epub before print, Feb 2013.E. Branchetti, R. Sainger, P. Poggio, J.B. Grau, J. Patterson-Fortin, J.E. Bavaria, M. Chorny, E. Lai, R.C. Gorman, R.J. Levy, G. Ferrari: Antioxidant Enzymes Reduce DNA Damage and Early Activation of Valvular Interstitial Cells in Aortic Valve Sclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 33(2): e66-74, Feb 2013.
M. Chorny, I.S. Alferiev, I. Fishbein, J.E. Tengood, Z. Folchman-Wagner, S.P. Forbes, R.J. Levy: Formulation and in vitro characterization of composite biodegradable magnetic nanoparticles for magnetically guided cell delivery. Pharmaceutical Research 29(5): 1232-1241, May 2012.
M. Chorny*, E. Hood*, R.J. Levy, V.R. Muzykantov : Endothelial delivery of antioxidant enzymes loaded into non-polymeric magnetic nanoparticles. Journal of Controlled Release 146(1): 144-51, Aug 2010.
M. Chorny*, I. Fishbein*, B.B. Yellen, I.S. Alferiev, M. Bakay, S. Ganta, R. Adamo, M. Amiji, G. Friedman, R.J. Levy : Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields. Proceedings of the National Academy of Sciences of the United States of America 107(18): 8346-51, May 2010.
M. Chorny, I. Fishbein, I.S. Alferiev, R.J. Levy: Magnetically responsive biodegradable nanoparticles enhance adenoviral gene transfer in cultured smooth muscle and endothelial cells Molecular Pharmaceutics 6(5): 1380-7, Jun 2009.
E. Cohen-Sela, S. Teitlboim, M. Chorny, N. Koroukhov, H.D. Danenberg, J. Gao, G. Golomb: Single and double emulsion manufacturing techniques of an amphiphilic drug in PLGA nanoparticles: formulations of mithramycin and bioactivity. Journal of Pharmaceutical Sciences 98(4): 1452-62, Apr 2009.
E. Cohen-Sela, M. Chorny, N. Koroukhov, H.D. Danenberg, G. Golomb: A new double emulsion solvent diffusion technique for encapsulating hydrophilic molecules in PLGA nanoparticles. Journal of Controlled Release 133(2): 90-5, Jan 2009.
B. Polyak, I. Fishbein, M. Chorny, I. Alferiev, D. Williams, B. Yellen, G. Friedman, R.J. Levy: High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents. Proceedings of the National Academy of Sciences of the United States of America 105(2): 698-703, Jan 2008.
H. Epstein, L. Rabinovich, S. Banai, V. Elazar, J. Gao, M. Chorny, H.D. Danenberg, G. Golomb: Predicting in vivo efficacy of potential restenosis therapies by cell culture studies: species-dependent susceptibility of vascular smooth muscle cells. The Open Cardiovascular Medicine Journal 2: 60-9, 2008.