Michael Chorny, PhD

faculty photo
Research Associate Professor of Pediatrics
Department: Pediatrics

Contact information
The Abramson Pediatric Research Center, Suite 702G
The Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-590-3063
BPharm (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 1996.
MS (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 1997.
PhD (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 2004.
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Description of Research Expertise

delivery systems; biodegradable nanocarriers; magnetic targeting of small molecule drugs and biotherapeutics; prodrug and codrug design; targeted therapy of proliferative diseases, arterial restenosis and pediatric solid tumors; neuroblastoma

Selected Publications

I. Fishbein, D. Guerrero, I.S. Alferiev, J. Foster, N. Minutolo, M. Chorny, A.M. Monteys, K.H. Driesbaugh, C. Nagaswami, R.J. Levy: Stent-based delivery of adeno-associated viral vectors with sustained vascular transduction and iNOS-mediated inhibition of in-stent restenosis. Gene Therapy 24(11): 717-726, Nov 2017.

M.R. Battig, I. Fishbein, R.J. Levy, I.S. Alferiev, D. Guerrero, M. Chorny: Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system. Drug Delivery and Translational Research Jul 2017.

I. Fishbein, T. Welch, D.T. Guerrero, I.S. Alferiev, R.F. Adamo, M. Chorny, R.K. Gupte, Y. Tang, R.J. Levy: Paraffin processing of stented arteries using a postfixation dissolution of metallic and polymeric stents. Cardiovascular Patholology 25(6): 483-88, Sep 2016.

R.F. Adamo, I. Fishbein, K. Zhang, J. Wen, R.J. Levy, I.S. Alferiev, M. Chorny: Magnetically enhanced cell delivery for accelerating recovery of the endothelium in injured arteries. Journal of Controlled Release 222: 169-75, Jan 2016.

I.S. Alferiev, R. Iyer, J.L. Croucher, R.F. Adamo, K. Zhang, J.L. Mangino, V. Kolla, I. Fishbein, G.M. Brodeur, R.J. Levy, M. Chorny: Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. Biomaterials 51: 22-9, May 2015.

R. Iyer*, J.L. Croucher*, M. Chorny*, J.L. Mangino, I.S. Alferiev, R.J. Levy, V. Kolla, G.M. Brodeur: Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma. Cancer Letters 360(2): 205-12, May 2015 Notes: (* equal contribution).

P.C. Naha, A. Al Zaki, E. Hecht, M. Chorny, P. Chhour, E. Blankemeyer, D.M. Yates, W.R.T. Witschey, H.I. Litt, A. Tsourkas, D.P. Cormode: Dextran coated bismuth-iron oxide nanohybrid contrast agents for computed tomography and magnetic resonance imaging. Journal of Materials Chemistry. B, Materials for Biology and Medicine 2: 8239-48, Oct 2014.

I. Fishbein, S.P. Forbes, R.F. Adamo, M. Chorny, R.J. Levy, I.S. Alferiev: Vascular gene transfer from metallic stent surfaces using adenoviral vectors tethered through hydrolysable cross-linkers. Journal of Visualized Experiments 90: e51653, Aug 2014.

M.D. Howard, E.D. Hood, C.F. Greineder, I.S. Alferiev, M. Chorny, V. Muzykantov: Targeting to endothelial cells augments the protective effect of novel dual bioactive antioxidant/anti-inflammatory nanoparticles. Molecular Pharmaceutics 11(7): 2262-70, Jul 2014.

E.D. Hood, M. Chorny, C.F. Greineder, I.S. Alferiev, R.J. Levy, V.R. Muzykantov: Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation. Biomaterials 35(11): 3708-15, Apr 2014.

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Last updated: 04/10/2018
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