Michael Chorny, PhD

faculty photo
Research Associate Professor of Pediatrics
Department: Pediatrics

Contact information
The Abramson Pediatric Research Center, Suite 702G
The Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-590-3063
Education:
BPharm (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 1996.
MS (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 1997.
PhD (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 2004.
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Description of Research Expertise

delivery systems; biodegradable nanocarriers; magnetic targeting of small molecule drugs and biotherapeutics; prodrug and codrug design; targeted therapy of proliferative diseases, arterial restenosis and pediatric solid tumors; neuroblastoma

Selected Publications

Y. Polunin, I.S. Alferiev, G.M. Brodeur, A. Voronov*, M. Chorny*: Environment-sensitive polymeric micelles encapsulating SN-38 potently suppress growth of neuroblastoma cells exhibiting intrinsic and acquired drug resistance. ACS Pharmacology & Translational Science 4(1): 240-247, Feb 2021 Notes: * equal contribution.

F. Nguyen, P. Guan, D.T. Guerrero, V. Kolla, K. Naraparaju, L.M. Perry, D. Soberman, B.B. Pressly, I.S. Alferiev*, M. Chorny*, G.M. Brodeur*: Structural optimization and enhanced prodrug-mediated delivery overcomes camptothecin resistance in high-risk solid tumors. Cancer Research 80(19): 4258–4265, Oct 2020 Notes: * equal contribution.

I. Orienti, G. Farruggia, F. Nguyen, P. Guan, N. Calonghi, V. Kolla, M. Chorny, G.M. Brodeur: Nanomicellar lenalidomide–fenretinide combination suppresses tumor growth in an MYCN amplified neuroblastoma tumor. International Journal of Nanomedicine 15: 6873-6886, Sep 2020.

M.R. Battig, I.S. Alferiev, D.T. Guerrero, I. Fishbein, B.B. Pressly, R.J. Levy, M. Chorny: Experimental single-platform approach to enhance the functionalization of magnetically targetable cells. ACS Applied Bio Materials 3(6): 3914-3922, May 2020.

W. Shield III, A. Cellini, H. Tian , K. Wilson, Y. Dan, J.M. Abzug, S. Garcia, N. Moritani, I. Alferiev, M. Chorny, M. Takigawa, V.Y. Ng, M. Iwamoto, M. Enomoto-Iwamoto: Selective agonists for nuclear retinoic acid receptor gamma inhibit growth of HCS-2/8 chondrosarcoma cells. Journal of Orthopaedic Research 38(5): 1045-1051, May 2020.

I. Orienti, F. Nguyen, P. Guan, V. Kolla, N. Calonghi, G. Farruggia, M. Chorny, G.M. Brodeur: A novel nanomicellar combination of fenretinide and lenalidomide shows marked antitumor activity in a neuroblastoma xenograft model. Drug Design, Development and Therapy 13: 4305-4319, Dec 2019.

M.R. Battig, I. Fishbein, R.J. Levy, I.S. Alferiev, D. Guerrero, M. Chorny: Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system. Drug Delivery and Translational Research 8(4): 954-963, Aug 2018.

F. Nguyen, I. Alferiev, P. Guan, D.T. Guerrero, V. Kolla, G.S. Moorthy, M. Chorny*, G.M. Brodeur*: Enhanced intratumoral delivery of SN38 as a tocopherol oxyacetate prodrug using nanoparticles in a neuroblastoma xenograft model. Clinical Cancer Research 24(11): 2585-2593, Jun 2018 Notes: (* equal contribution).

I. Fishbein, D. Guerrero, I.S. Alferiev, J. Foster, N. Minutolo, M. Chorny, A.M. Monteys, K.H. Driesbaugh, C. Nagaswami, R.J. Levy: Stent-based delivery of adeno-associated viral vectors with sustained vascular transduction and iNOS-mediated inhibition of in-stent restenosis. Gene Therapy 24(11): 717-726, Nov 2017.

I. Fishbein, T. Welch, D.T. Guerrero, I.S. Alferiev, R.F. Adamo, M. Chorny, R.K. Gupte, Y. Tang, R.J. Levy: Paraffin processing of stented arteries using a postfixation dissolution of metallic and polymeric stents. Cardiovascular Patholology 25(6): 483-88, Sep 2016.

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Last updated: 02/15/2021
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