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Carsten C. Skarke, M.D.

Carsten C. Skarke, M.D.

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Research Assistant Professor of Medicine
Department: Medicine

Contact information
Institute for Translational Medicine and Therapeutics (ITMAT)
8036 Maloney Building
3600 Spruce Street
Philadelphia, PA 19104
Office: (215) 746-8330
Fax: (215) 573-8996
MD (Medicine)
Johannes Gutenberg-University School of Medicine, Mainz, Germany, 1998.
Dr. med. (Pathology)
Johannes Gutenberg-University School of Medicine, Mainz, Germany, 2000.
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Description of Research Expertise

Human Clock Biology: Dr. Skarke is studying the human chronobiome under basal and perturbed conditions in healthy volunteers integrating multiomics, clinical and remote sensing outputs. These reference data are necessary to interrogate the time dependence in the incidence or severity of disease phenotypes.

Human Lipid Biology: Dr. Skarke is pursuing the question whether the specialized pro-resolving mediators are formed in humans in concentrations of biological relevance.

Selected Publications

G. A. Fitzgerald, G. Yang, G. K. Paschos, X. Liang & C. Skarke: Molecular clocks and the human condition: approaching their characterization in human physiology and disease. Diabetes, Obesity and Metabolism 17(Suppl. 1): 139–142, September 2015.

Carsten Skarke, Naji Alamuddin, John A. Lawson, Xuanwen Li, Jane F. Ferguson, Muredach P. Reilly and Garret A. FitzGerald: Bioactive products formed in humans from fish oils. Journal of Lipid Research 56(9): 1808-20, September 2015 Notes: [Featured in an Invited Commentary by Dr. Robert C. Murphy. Specialized pro-resolving mediators: Do They Circulate in Plasma? , J. Lipid Res. 2015 Sep;56(9):1641-2, PMID:26232500; and interviews in Medical Research & Cardiology Today]

Sarapee Hirankarn, Jeffrey S. Barrett, Naji Alamuddin, Garret A. FitzGerald, Carsten Skarke: GCG100649, A Novel Cyclooxygenase-2 Inhibitor, Exhibits a Drug Disposition Profile in Healthy Volunteers Compatible With High Affinity to Carbonic Anhydrase-I/II: Preliminary Dose–Exposure Relationships to Define Clinical Development Strategies. Clinical Pharmacology in Drug Development 2(4): 379–386, July 2013 Notes: DOI: 10.1002/cpdd.47.

Skarke C, Alamuddin N, Lawson JA, Cen L, Propert KJ, FitzGerald GA: Comparative impact on prostanoid biosynthesis of celecoxib and the novel nonsteroidal anti-inflammatory drug CG100649. Clin Pharmacol Ther 91(6): 986-93, June 2012.

Skarke C, Kuczka K, Tausch L, Werz O, Rossmanith T, Barrett JS, Harder S, Holtmeier W, Schwarz JA: Increased bioavailability of 11‑keto-beta-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: Modeling and simulation considerations for evaluating drug exposures. J Clin Pharmacol 52(10): 1592-1600, October 2012.

Skarke Carsten, FitzGerald Garret A: Training translators for smart drug discovery. Science Translational Medicine. American Association for the Advancement of Science, 2(26): 26cm12, April 2010.

Skarke C, Reus M, Schmidt R, Grundei I, Schuss P, Geisslinger G, Lötsch J: The cyclooxygenase-2 genetic variant -765G>C does not modulate the effects of celecoxib on prostaglandin E2 production. Clin Pharmacol Ther 80(6): 621-632, December 2006.

Skarke C, Langer M, Jarrar M, Schmidt H, Geisslinger G, Lötsch J: Probenecid interacts with the pharmacokinetics of morphine-6-glucuronide in humans. Anesthesiology 101(6): 1394-1399, December 2004.

Skarke C, Jarrar M, Erb K, Schmidt H, Geisslinger G, Lötsch J : Respiratory and miotic effects of morphine in healthy volunteers when P-glycoprotein is blocked by quinidine. Clin Pharmacol Ther 74(4): 303-311, October 2003.

Skarke C, Jarrar M, Schmidt H, Kauert G, Langer M, Geisslinger G, Lötsch J: Effects of ABCB1 (multi drug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers. Pharmacogenetics 13(11): 651-660, November 2003.

Skarke C, Darimont J, Schmidt H, Geisslinger G, Lotsch J: Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers. Clin Pharmacol Ther 73(1): 107-121, January 2003.

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Last updated: 07/19/2016
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