Carsten C. Skarke, M.D.

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Adjunct Associate Professor of Medicine (Experimental Therapeutics)
Robert L. McNeil, Jr Fellow in Translational Medicine, Institute for Translational Medicine and Therapeutics, University of Pennsylvania
Director, CTSA Translational Research Internship Program (TRIP), Institute for Translational Medicine and Therapeutics, University of Pennsylvania
Sr. Research Investigator , Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania Perelman School of Medicine
Department: Medicine

Contact information
Institute for Translational Medicine and Therapeutics (ITMAT)
University of Pennsylvania Perelman School of Medicine
Smilow Center for Translational Research 10-101
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: (215) 573-0673
MD (Medicine)
Johannes Gutenberg-University School of Medicine, Mainz, Germany, 1998.
Dr. med. (Pathology)
Johannes Gutenberg-University School of Medicine, Mainz, Germany, 2000.
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Description of Research Expertise

Translational Chronobiology
Dr. Skarke is studying oscillatory functional networks in the human chronobiome under basal and perturbed conditions, the modulation of these oscillatory functional networks by sex and age and their deconsolidation by disease. Time-specific study paradigms integrate a broad array of multiomics, clinical and remote sensing outputs. These studies accomplish the time-specific deep phenotyping at unprecedented scale.

Description of Other Expertise

Training the Next Generation of Clinical and Translational Scientists
Dr. Skarke directs ITMAT Education's Translational Research Immersion Program (TRIP) which provides undergraduate students from participating institutions experiential learning opportunities in the field of clinical and translational research (CTR). TRIP accomplishes exposure, access and networking in CTR.

Building a Diverse, Inclusive Clinical & Translational Workforce
Through Dr. Skarke's leadership, TRIP is now partnering with 12 institutions, specifically Bryn Mawr College, Haverford College, Howard University, Florida A&M University, Franklin & Marshall College, Lincoln University, Morehouse College, Spelman College, Swarthmore College, University of Pennsylvania, University of Puerto Rico, and Xavier University of Louisiana. TRIP has become a gateway to promote inclusive and diverse growth in the clinical and translational sciences.

Science to Art to Society and back!
Dr. Skarke established the inaugural artist-in-residence program embedded into TRIP 2022. The artist will witness the evolution of science research projects among our cohort of TRIP students and will translate their observations into work of art. This translational process will capture not only the science and scientific process but also the human experience embodied in emotions. Community members can relate to these emotions and thus become receptive to engage with science.

Selected Publications

Carsten Skarke, Nicholas Lahens, Seth Rhoades, Amy Campbell, Kyle Bittinger, Aubrey Bailey, Christian Hoffmann, Randal S. Olson, Lihong Chen1, Guangrui Yang, Thomas S. Price, Jason H. Moore, Frederic D. Bushman, Casey S. Greene, Gregory R. Grant, Aalim M. Weljie & Garret A. FitzGerald : A Pilot Characterization of the Human Chronobiome. Scientific Reports 7(1): 17141:1-12, December 2017 Notes: Cited 25 times; Altmetric score of 108.

G. A. Fitzgerald, G. Yang, G. K. Paschos, X. Liang & C. Skarke: Molecular clocks and the human condition: approaching their characterization in human physiology and disease. Diabetes, Obesity and Metabolism 17(Suppl. 1): 139–142, September 2015.

Bhavna N. Desai, Garima Singhal, Mikiko Watanabe, Darko Stevanovic, Thomas L. Lundasen, Marie Mather, Hilde G. Verdeh, Folliott M. Fisher, Andrew C. Adams, Imad A. Nasser, Gerald A. FitzGerald, Jeffrey S. Flier, Carsten Skarke, Eleftheria Maratos-Flier: Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury. Molecular Metabolism. Elsevier, 6(11): 1395-1406, November 2017 Notes: Dr. Skarke is co-senior author.

Carsten Skarke, Naji Alamuddin, John A. Lawson, Xuanwen Li, Jane F. Ferguson, Muredach P. Reilly and Garret A. FitzGerald: Bioactive products formed in humans from fish oils. Journal of Lipid Research 56(9): 1808-20, September 2015 Notes: Featured in a commentary in the same JLR issue; press coverage (Medical Research, Cardiology Today); cited 61 times; Altmetric score of 70.

Sarapee Hirankarn, Jeffrey S. Barrett, Naji Alamuddin, Garret A. FitzGerald, Carsten Skarke: GCG100649, A Novel Cyclooxygenase-2 Inhibitor, Exhibits a Drug Disposition Profile in Healthy Volunteers Compatible With High Affinity to Carbonic Anhydrase-I/II: Preliminary Dose–Exposure Relationships to Define Clinical Development Strategies. Clinical Pharmacology in Drug Development 2(4): 379–386, July 2013 Notes: DOI: 10.1002/cpdd.47.

Skarke C, Alamuddin N, Lawson JA, Cen L, Propert KJ, FitzGerald GA: Comparative impact on prostanoid biosynthesis of celecoxib and the novel nonsteroidal anti-inflammatory drug CG100649. Clin Pharmacol Ther 91(6): 986-93, June 2012.

Skarke Carsten, FitzGerald Garret A: Training translators for smart drug discovery. Science Translational Medicine. American Association for the Advancement of Science, 2(26): 26cm12, April 2010.

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Last updated: 02/15/2023
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