Nuala J. Meyer, MD, MS (MTR)
Nuala J. Meyer, MD, MS (MTR)
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine
Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
3400 Spruce Street
8026 Maloney (mail)
5 W. Gates (office)
Philadelphia, PA 19104
Hospital of the University of Pennsylvania
3400 Spruce Street
8026 Maloney (mail)
5 W. Gates (office)
Philadelphia, PA 19104
Office: 215-662-7049
Fax: 215-614-0869
Fax: 215-614-0869
Email:
nuala.meyer@uphs.upenn.edu
nuala.meyer@uphs.upenn.edu
Publications
Education:
B.S. (Biology)
Yale University, 1996.
M.D. (Medicine)
University of Chicago, Pritzker School of Medicine, 2000.
M.S. (Translational Research)
University of Pennsylvania, 2011.
Permanent linkB.S. (Biology)
Yale University, 1996.
M.D. (Medicine)
University of Chicago, Pritzker School of Medicine, 2000.
M.S. (Translational Research)
University of Pennsylvania, 2011.
Description of Clinical Expertise
Critical Care MedicineAcute respiratory distress syndrome
Septic shock
Pulmonary medicine
Description of Research Expertise
Dr. Meyer’s research focuses on identifying genetic and molecular risk factors for acute respiratory distress syndrome and organ dysfunction during critical illness. She seeks to leverage genetic risk profiles to allow the development of personalized therapy for sepsis and ARDS. By directing a cohort of patients with severe sepsis, Dr. Meyer’s research spans the clinical, genetic, and molecular fields, translating human associations with lung injury into mechanistic insights as to how acute lung injury occurs, and transforming this enhanced understanding into improved care for patients.Selected Publications
Meyer Nuala J, Li Mingyao, Feng Rui, Bradfield Jonathan, Gallop Robert, Bellamy Scarlett, Fuchs Barry D, Lanken Paul N, Albelda Steven M, Rushefski Melanie, Aplenc Richard, Abramova Helen, Atochina-Vasserman Elena N, Beers Michael F, Calfee Carolyn S, Cohen Mitchell J, Pittet Jean-Francois, Christiani David C, O'Keefe Grant E, Ware Lorraine B, May Addison K, Wurfel Mark M, Hakonarson Hakon, Christie Jason D: ANGPT2 Genetic Variant Is Associated with Trauma-associated Acute Lung Injury and Altered Plasma Angiopoietin-2 Isoform Ratio. American Journal of Respiratory and Critical Care Medicine 183(10): 1344-53, May 2011.Christie Jason D, Wurfel Mark M, Feng Rui, O'Keefe Grant E, Bradfield Jonathan, Ware Lorraine B, Christiani David C, Calfee Carolyn S, Cohen Mitchell J, Matthay Michael, Meyer Nuala J, Kim Cecilia, Li Mingyao, Akey Joshua, Barnes Kathleen C, Sevransky Jonathan, Lanken Paul N, May Addison K, Aplenc Richard, Maloney James P, Hakonarson Hakon: Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PloS one 7(1): e28268, Jan 2012.
Dolinay Tamás, Kim Young Sam, Howrylak Judie, Hunninghake Gary M, An Chang Hyeok, Fredenburgh Laura, Massaro Anthony F, Rogers Angela, Gazourian Lee, Nakahira Kiichi, Haspel Jeffrey A, Landazury Roberto, Eppanapally Sabitha, Christie Jason D, Meyer Nuala J, Ware Lorraine B, Christiani David C, Ryter Stefan W, Baron Rebecca M, Choi Augustine M K: Inflammasome-Regulated Cytokines are Critical Mediators of Acute Lung Injury. American Journal of Respiratory and Critical Care Medicine Mar 2012.
Shashaty Michael G S, Meyer Nuala J, Localio A Russell, Gallop Robert, Bellamy Scarlett L, Holena Daniel N, Lanken Paul N, Kaplan Sandra, Yarar Dilek, Kawut Steven M, Feldman Harold I, Christie Jason D: African American race, obesity, and blood product transfusion are risk factors for acute kidney injury in critically ill trauma patients. Journal of Critical Care May 2012.
Mitra Sumegha, Sammani Saad, Wang Ting, Boone David L, Meyer Nuala J, Dudek Steven M, Moreno-Vinasco Liliana, Garcia Joe G N, Jacobson Jeffrey R: Role of growth arrest and DNA damage-inducible α in Akt phosphorylation and ubiquitination after mechanical stress-induced vascular injury. American Journal of Respiratory and Critical Care Medicine 184(9): 1030-40, Nov 2011.
Mikkelsen Mark E, Shah Chirag V, Scherpereel Arnaud, Lanken Paul N, Lassalle Philippe, Bellamy Scarlett L, Localio A Russell, Albelda Steven M, Meyer Nuala J, Christie Jason D: Lower serum endocan levels are associated with the development of acute lung injury after major trauma. Journal of Critical Care Sep 2011.
Meyer Nuala J, Christie Jason D: von Willebrand factor and angiopoietin-2: Toward an acute lung injury endothelial endophenotype?* Critical Care Medicine 40(6): 1966-7, Jun 2012.
Rushefski Melanie, Aplenc Richard, Meyer Nuala, Li Mingyao, Feng Rui, Lanken Paul N, Gallop Robert, Bellamy Scarlett, Localio A Russell, Feinstein Sheldon I, Fisher Aron B, Albelda Steven M, Christie Jason D: Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma. BMC Medical Genetics 12: 77, May 2011.
Meyer NJ, Christie JD: The next generation of ALI genetics: insights into pathophysiology. In: Annual Update in Intensive Care and Emergency Medicine 2011. JL Vincent (eds.). Springer, Page: 97-108, March 2011 Notes: DOI 10.1007/978-3-642-18081-1.
Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, ... Meyer NJ, ... de Bakker PI, Delles C, Duggan D, Hingorani AD, Hirschhorn JN, Hofker MH, Humphries SE, Kivimaki M, Lawlor DA, Kottke-Marchant K, Mega JL, Mitchell BD, Morrow DA, Palmen J, Redline S, Shields DC, Shuldiner AR, Sleiman PM, Smith GD, Farrall M, Jamshidi Y, Christiani DC, Casas JP, Hall AS, Doevendans PA, Christie JD, Berenson GS, Murray SS, Illig T, Dorn GW 2nd, Cappola TP, Boerwinkle E, Sever P, Rader DJ, Reilly MP, Caulfield M, Talmud PJ, Topol E, Engert JC, Wang K, Dominiczak A, Hamsten A, Curtis SP, Silverstein RL, Lange LA, Sabatine MS, Trip M, Saleheen D, Peden JF, Cruickshanks KJ, März W, O'Connell JR, Klungel OH, Wijmenga C, Maitland-van der Zee AH, Schadt EE, Johnson JA, Jarvik GP, Papanicolaou GJ; Hugh Watkins on behalf of PROCARDIS, Grant SF, Munroe PB, North KE, Samani NJ, Koenig W, Gaunt TR, Anand SS, van der Schouw YT; Meena Kumari on behalf of the Whitehall II Study and the WHII 50K Group, Soranzo N, Fitzgerald GA, Reiner A, Hegele RA, Hakonarson H, Keating BJ: Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet 88(1): 6-18, Jan 2011.