Lachlan James Smith, Ph.D.

faculty photo
Assistant Professor of Neurosurgery
Department: Neurosurgery

Contact information
McKay Orthopaedic Research Laboratory
111A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 215-898-8653
Fax: 215-573-2133
Education:
B.E. (Mechatronic Engineering)
University of Adelaide, 2001.
Ph.D. (Pathology)
University of Adelaide, 2008.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

The focus of my research program is the pathophysiology and treatment of degenerative and developmental disorders affecting the spine, particularly those affecting the intervertebral discs and vertebral bones. The scope of our research includes basic mechanistic studies, translational studies in animal models, and clinical studies in human patients. We use cutting edge techniques in molecular biology, biochemistry and bioengineering, coupled with novel in vitro model systems to study disease mechanisms. Our research in the translational space bridges the fields of tissue engineering, biomaterials, drug delivery and stem cells, and is focused on arresting disease progression, restoring spine function and potentiating long term tissue regeneration. We use novel, naturally occurring and inducible large and small animal models to study disease etiology and evaluate therapeutics. Our multidisciplinary team includes biologists, bioengineers, clinicians and veterinarians.

Selected Publications

Gullbrand SE, Schaer TP, Agarwal P, Bendigo JR, Dodge GR, Chen W, Elliott DM, Mauck RL, Malhotra NR, Smith LJ: Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model. Acta Biomaterialia 60, Sept 2017.

Peck SH, McKee KK, Tobias JW, Malhotra NR, Harfe BD, Smith LJ: Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus. Scientific Reports Sept 2017.

Tong W, Luc Z, Qin L, Mauck RL, Smith HE, Smith LJ, Malhotra NR, Heyworth MF, Caldera F, Enomoto-Iwamoto M, Zhang Y: Cell Therapy for the Degenerating Intervertebral Disc. Translational Research 181, Mar 2017.

Martin JT, Kim DH, Milby AH, Pfeifer CG, Smith LJ, Elliott DM, Smith HE, Mauck RL: In vivo performance of an acellular disc-like angle ply structure (DAPS) for total disc replacement in a small animal model. Journal of Orthopaedic Research 35(1), Jan 2017.

Gullbrand SE, Malhotra NR, Schaer TP, Zawacki Z, Martin JT, Bendigo J, Milby AH, Dodge GR, Vresilovic EJ, Elliott DM, Mauck RL, Smith LJ: A Large Animal Model that Recapitulates the Spectrum of Human Intervertebral Disc Degeneration. Osteoarthritis and Cartilage 25(1): 146-156, Jan 2017.

Gullbrand SE, Schaer TP, Bendigo JR, Agarwal P, Zawacki Z, Dodge GR, Vresilovic EJ, Elliott DM, Mauck RL, Malhotra NR, Smith LJ: Stem Cell Seeded Injectable Hydrogels for Intervertebral Disc Regeneration in a Preclinical Animal Model. 63rd Annual Meeting, Orthopaedic Research Society, San Diego, USA 2017 Notes: Podium.

Gullbrand SE, Martin JT, Ashinsky BG, Kim DH, Smith LJ, Elliott DM, Smith HE, Mauck RL: Engineered Endplates Enhance the In Vivo Performance of a Replacement Disc-Like Angle Ply Structure (DAPS). 63rd Annual Meeting, Orthopaedic Research Society, San Diego, USA 2017 Notes: Podium. NIRA award winner.

Bendigo JR, Gullbrand SE, Stoeckl BD, Zawacki Z, Schaer TP, Smith HE, Mauck RL, Malhotra NR, Qu F, Smith LJ: Novel Techniques for the Evaluation of Physical Activity in a Large Animal Intervertebral Disc Degeneration Model. 63rd Annual Meeting, Orthopaedic Research Society, San Diego, USA 2017 Notes: Poster.

Martin JT, Gullbrand SE, Mohanraj B, Ashinsky BG, Kim DH, Ikuta K, Elliott DM, Smith LJ, Mauck RL, Smith HE: Optimization of pre-culture conditions to maximize in vivo performance of tissue engineered total disc replacements. Tissue Engineering Part A In press, 2017.

Peck SH, McKee KK, Malhotra NR, Harfe BD, Smith LJ: Growth Factor and Extracellular Matrix Expression and Localization during Nucleus Pulposus Formation. 63rd Annual Meeting, Orthopaedic Research Society, San Diego, USA 2017 Notes: Podium.

back to top
Last updated: 09/03/2017
The Trustees of the University of Pennsylvania