Lachlan James Smith, Ph.D.

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Assistant Professor of Neurosurgery
Department: Neurosurgery

Contact information
McKay Orthopaedic Research Laboratory
111A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 215-898-8653
Fax: 215-573-2133
Education:
B.E. (Mechatronic Engineering)
University of Adelaide, 2001.
Ph.D. (Pathology)
University of Adelaide, 2008.
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Description of Research Expertise

The focus of my research program is the pathophysiology and treatment of degenerative and developmental disorders affecting the spine, particularly those affecting the intervertebral discs and vertebral bones. The scope of our research includes basic mechanistic studies, translational studies in animal models, and clinical studies in human patients. We use cutting edge techniques in molecular biology, biochemistry and bioengineering, coupled with novel in vitro model systems to study disease mechanisms. Our research in the translational space bridges the fields of tissue engineering, biomaterials, drug delivery and stem cells, and is focused on arresting disease progression, restoring spine function and potentiating long term tissue regeneration. We use novel, naturally occurring and inducible large and small animal models to study disease etiology and evaluate therapeutics. Our multidisciplinary team includes biologists, bioengineers, clinicians and veterinarians.

Selected Publications

Kim DH, Gullbrand SE, Elliott DM, Smith LJ, Smith HE, Mauck RL: TGF-β Improves Cell Viability in Human-Sized Disc-Like Angle Ply Structures (DAPS). 64th Annual Meeting, Orthopaedic Research Society, New Orleans, USA 2018 Notes: Poster presentation.

Gullbrand SE, Ashinsky BG, Kim DH, Smith LJ, Elliott DM, Smith HE, Mauck RL: The Effect of Remobilization on the In Vivo Function of an Endplate-Modified Engineered Disc. 64th Annual Meeting, Orthopaedic Research Society, New Orleans, USA 2018 Notes: Poster presentation.

Peck SH, Bendigo JR, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Donor-Dependent Effects on the Survival and Extracellular Matrix Producing Capacity of Mesenchymal Stem Cells following Hypoxia and TGF-β Conditioning. 64th Annual Meeting, Orthopaedic Research Society, New Orleans, USA 2018 Notes: Poster presentation.

Gullbrand SE, Kim DH, Bonnevie E, Ashinsky BG, Elliott DM, Smith LJ, Smith HE, Mauck RL: Characterization of Disc-Like Angle Ply Structures for Total Disc Replacement at Clinically Relevant Size Scales. 64th Annual Meeting, Orthopaedic Research Society, New Orleans, USA 2018.

Piazza M, Peck SH, Gullbrand SE, Bendigo JR, Arginteanu T, Smith HE, Malhotra NR, Smith LJ: Quantitative magnetic resonance imaging correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration. 64th Annual Meeting, Orthopaedic Research Society, New Orleans, USA 2018 Notes: Poster presentation.

Martin JT, Gullbrand SE, Kim DH, Ikuta K, Pfeifer C.G., Ashinsky B.G., Smith LJ, Elliott DM, Smith HE, Mauck RL: In Vitro Maturation and In Vivo Integration and Function of an Engineered Cell-Seeded Disc-like Angle Ply Structure (DAPS) for Total Disc Arthroplasty. Scientific Reports 7(1): 15765, Nov 2017.

Martin JT, Gullbrand SE, Mohanraj B, Ashinsky BG, Kim DH, Ikuta K, Elliott DM, Smith LJ, Mauck RL, Smith HE: Optimization of pre-culture conditions to maximize in vivo performance of tissue engineered total disc replacements. Tissue Engineering Part A 23(17-18): 932-934, Sept 2017.

Peck SH, McKee KK, Tobias JW, Malhotra NR, Harfe BD, Smith LJ: Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus. Scientific Reports 7(1): 10504, Sept 2017.

Gullbrand SE, Schaer TP, Agarwal P, Bendigo JR, Dodge GR, Chen W, Elliott DM, Mauck RL, Malhotra NR, Smith LJ: Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model. Acta Biomaterialia 60: 201-209, Sept 2017.

Tong W, Luc Z, Qin L, Mauck RL, Smith HE, Smith LJ, Malhotra NR, Heyworth MF, Caldera F, Enomoto-Iwamoto M, Zhang Y: Cell Therapy for the Degenerating Intervertebral Disc. Translational Research 181, Mar 2017.

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Last updated: 12/15/2017
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