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Lachlan James Smith, Ph.D.

Lachlan James Smith, Ph.D.

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Assistant Professor of Neurosurgery
Department: Neurosurgery

Contact information
424 Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Education:
B.E. (Mechatronic Engineering)
University of Adelaide, 2001.
Ph.D. (Pathology)
University of Adelaide, 2008.
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Description of Research Expertise

The focus of my research program is the pathophysiology and treatment of degenerative and developmental disorders affecting the spine, particularly those affecting the intervertebral discs and vertebral bones. The scope of our research includes basic mechanistic studies, translational studies in animal models, and clinical studies in human patients. We use cutting edge techniques in molecular biology, biochemistry and bioengineering, coupled with novel in vitro model systems to study disease mechanisms. Our research in the translational space bridges the fields of tissue engineering, biomaterials, drug delivery and stem cells, and is focused on arresting disease progression, restoring spine function and potentiating long term tissue regeneration. We use novel, naturally occurring and inducible large and small animal models to study disease etiology and evaluate therapeutics. Our multidisciplinary team includes biologists, bioengineers, clinicians and veterinarians.

Selected Publications

Simonaro CM, Tomatsu S, Sikora T, Kubaski F, Frohbergh M, Guevara JM, Wang RY, Vera M, Kang JL, Smith LJ, Schuchman EH, Haskins ME: Pentosan Polysulfate: Oral Versus Subcutaneous Injection in Mucopolysaccharidosis Type I Dogs. PLoS One 11(4), April 2016.

Han WM, Heo SJ, White RE, Driscoll TP, Macleod CM, Smith LJ, Duncan RL, Mauck RL, Elliott DM: Microstructural heterogeneity in native and engineered fibrocartilage directs tissue micromechanics and mechanobiology. Nature Materials Page: In Press, Jan 2016.

Peck SH, Casal ML, Malhotra NR, Ficicioglu C, Smith LJ: Pathogenesis and Treatment of Spine Disease in the Mucopolysaccharidoses. Molecular Genetics and Metabolism In press, 2016.

Gullbrand SE, Ashinsky BG, Martin JT, Pickup S, Smith LJ, Mauck RL, Smith HE: Correlations between Quantitative T2 and T1ρ MRI, Mechanical Properties and Biochemical Composition in a Rabbit Intervertebral Disc Degeneration Model. Journal of Orthopaedic Research In press, 2016.

Martin JT, Milby AH, Pfeifer CG, Kim DH, Smith LJ, Elliott DM, Smith HE, Mauck RL: Intermediate and long-term outcomes of an acellular disc-like angle ply structure (DAPS) for intervertebral disc replacement in a small animal model. Journal of Orthopaedic Research In press, 2016.

Peck SH, McKee KK, Malhotra NR, Mauck RL, Tobias JW, Harfe BD, Smith LJ: Whole-Transcriptome Profiling of Notochord-Derived Cells during Embryonic Nucleus Pulposus Formation. 62nd Annual Meeting, Orthopaedic Research Society, Orlando, USA 2016 Notes: Podium - presented by trainee (S Peck) - Won First Prize.

Kim DH, Martin JT, Gullbrand SE, Pfeifer CG, Elliott DG, Smith LJ, Smith HE, Mauck RL: Fabrication, Maturation, and Implantation of a Composite Tissue-Engineered Total Disc Replacement. 62nd Annual Meeting, Orthopaedic Research Society, Orlando, USA 2016 Notes: Poster.

Gullbrand SE, Ashinsky BG, Martin JT, Pickup S, Smith LJ, Mauck RL, Smith HE: Correlations between Quantitative T2 and T1ρ MRI Parameters and Mechanics and Biochemical Content in a Rabbit Disc Degeneration Model. 62nd Annual Meeting, Orthopaedic Research Society, Orlando, USA 2016 Notes: Podium - presented by trainee (S Gullbrand).

Kim DH, Martin JT, Ikuta K, Smith HE, Elliott DM, Smith LJ, Mauck RL: Variations in Media Formulation Impact ECM Synthesis and Retention in NP Cell-laden HA Hydrogels. 62nd Annual Meeting, Orthopaedic Research Society, Orlando, USA 2016 Notes: Poster.

Martin JT, Gullbrand SE, Ashinsky BG, Kim DH, Ikuta K, Smith LJ, Elliott DM, Mauck RL, Smith HE: Optimization of in vitro pre-culture conditions to maximize in vivo performance of engineered intervertebral discs. 62nd Annual Meeting, Orthopaedic Research Society, Orlando, USA 2016 Notes: Poster.

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Last updated: 07/01/2016
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