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Lachlan James Smith, Ph.D.

Lachlan James Smith, Ph.D.

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Research Assistant Professor of Neurosurgery
Department: Neurosurgery

Contact information
424 Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
B.E. (Mechatronic Engineering)
University of Adelaide, 2001.
Ph.D. (Pathology)
University of Adelaide, 2008.
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Selected Publications

Kim DH, Martin JT, Elliott DM, Smith LJ, Mauck RL: Phenotypic Stability, Matrix Elaboration, and Functional Maturation of Nucleus Pulposus Cells Encapsulated in Photocrosslinkable Hyaluronic Acid Hydrogels. Acta Biomaterialia 15(12): 21-29, Jan 2015.

Farrell MJ, Shin JI, Smith LJ, Mauck RL: Functional consequences of glucose and oxygen deprivation on engineered mesenchymal stem cell-based cartilage constructs. Osteoarthritis Cartilage. 134-142 (eds.). 23(1), Jan 2015.

Peck SH, O’Donnell PJ, Chiaro JA, Shore EM, Pacifici M, Haskins ME, Malhotra NR, Smith LJ: Pinpointing the Earliest Manifestations of Bone Disease in Mucopolysaccharidosis Disorders. Orthopaedic Research Society Annual Meeting 2015 Notes: Poster.

Peck SH, O’Donnell PJ, Chiaro JA, Shore EM, Pacifici M, Haskins ME, Malhotra NR, Smith LJ: Failed vertebral bone formation in mucopolysaccharidosis VII dogs is associated with impaired chondrocyte hypertrophic differentiation. WORLD Symposium on Lysosomal Diseases, Orlando, USA 2015 Notes: Podium.

Gorth DG, Lothstein KE, Chiaro JA, Farrell MJ, Dodge GR, Elliott DM, Malhotra NR, Mauck RL, Smith LJ: Hypoxic Regulation of Functional Extracellular Matrix Elaboration by Nucleus Pulposus Cells in Long Term Agarose Culture. Journal of Orthopaedic Research 2015.

Lothstein KE, O’Donnell PJ, Peck SH, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Preconditioning Stem Cells to Maximize Regenerative Potential in the Challenging Microenvironment of the Intervertebral Disc. Orthopaedic Research Society Annual Meeting 2015 Notes: Poster.

Martin JT, Ikuta K, Kim DH, Pfeifer CG, Smith LJ, Elliott DM, Smith HE, Mauck RL: Growth Trajectory and In vivo Implantation of Cellular Nanofibrous Disc-like Angle Ply Structures for Total Disc Replacement. Orthopaedic Research Society Annual Meeting 2015 Notes: Podium.

Chiaro JA, O'Donnell P, Shore EM, Malhotra NR, Ponder KP, Haskins ME, Smith LJ: Effects of Neonatal Enzyme Replacement Therapy and Simvastatin Treatment on Cervical Spine Disease in Mucopolysaccharidosis I Dogs. Journal of Bone and Mineral Research 29(12): 2610-2617, Dec 2014.

Gorth DG, Martin JT, Dodge GR, Malhotra NR, Elliott DM, Mauck RL, Smith LJ: In Vivo Retention and Bioactivity of IL-1ra Microspheres in the Rat Caudal Intervertebral Disc: A Preliminary Investigation. Journal of Experimental Orthopaedics 1(15), Nov 2014.

Smith LJ, Gorth DJ, Showalter BL, Chiaro JA, Beattie EE, Chen W, Elliott DM, Mauck RL, Malhotra NR: In Vitro Characterization of a Stem Cell-Seeded Triple Interpenetrating Network Hydrogel for Functional Regeneration of the Nucleus Pulposus. Tissue Engineering. Tissue Engineering: Part A 20(13-14): 1841-1849, Jul 2014.

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Last updated: 09/01/2015
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