Lachlan James Smith, Ph.D.

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Associate Professor of Neurosurgery
Department: Neurosurgery

Contact information
McKay Orthopaedic Research Laboratory
378A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 215-746-2169
Fax: 215-573-2133
Education:
B.E. (Mechatronic Engineering)
University of Adelaide, 2001.
Ph.D. (Pathology)
University of Adelaide, 2008.
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Description of Research Expertise

The focus of my research program is the pathophysiology and treatment of degenerative and developmental disorders affecting the spine, particularly those affecting the intervertebral discs and vertebral bones. The scope of our research includes basic mechanistic studies, translational studies in animal models, and clinical studies in human patients. We use cutting edge techniques in molecular biology, biochemistry and bioengineering, coupled with novel in vitro model systems to study disease mechanisms. Our research in the translational space bridges the fields of tissue engineering, biomaterials, drug delivery and stem cells, and is focused on arresting disease progression, restoring spine function and potentiating long term tissue regeneration. We use novel, naturally occurring and inducible large and small animal models to study disease etiology and evaluate therapeutics. Our multidisciplinary team includes biologists, bioengineers, clinicians and veterinarians.

Selected Publications

Jiang Z, Lau YK, Wu M, Casal ML, Smith LJ: Ultrastructural Analysis of Different Skeletal Cell Types in Mucopolysaccharidosis Dogs at the Onset of Postnatal Growth. Journal of Anatomy In press, 2020.

Jiang Z, Johnson CP, Nykänen O, Nissi M, Lau YK, Wu M, Ludwig K, Ellerman J, Casal ML, Smith LJ: Abnormal Vascularity and Extracellular Matrix Remodeling are Associated with Delayed Secondary Ossification in Mucopolysaccharidosis VII. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020.

Jiang Z, Johnson CJ, Nykanen O, Nissi M, Lau YK, Wu M, Casal ML, Smith LJ: Epiphyseal Cartilage Canal Architecture and Extracellular Matrix Remodeling in Mucopolysaccharidosis VII Dogs at the Onset of Postnatal Growth. Connective Tissue Research In press, 2020.

Kim DH, Martin JT, Gullbrand SE, Elliott DM, Smith LJ, Smith HE, Mauck RL: Fabrication, Maturation, and Implantation of Composite Tissue-Engineered Total Discs Formed from Native and Mesenchymal Stem Cell Combinations. Acta Biomaterialia In Press, 2020.

Zhang C, Gullbrand SE, Schaer TP, Boorman S, Chen W, Elliott DM, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Combined Hydrogel and Mesenchymal Stem Cell Therapy for Moderate Severity Disc Degeneration in Goats. Tissue Engineering: Part A In Press, 2020.

Zhang C, Gullbrand SE, Schaer TP, Lau YK, Jiang Z, Elliott DM, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Inflammatory Cytokine and Catabolic Enzyme Expression in a Preclinical Goat Model of Intervertebral Disc Degeneration. Journal of Orthopaedic Research In Press, 2020.

Jiang Z, Byers S, Casal ML, Smith LJ: Failures of Endochondral Ossification in the Mucopolysaccharidoses. Current Osteoporosis Reports In press, 2020.

Gullbrand SE, Ashinsky BG, Bonnevie ED, Kim DH, Smith LJ, Elliott DM, Schaer TP, Smith HE, Mauck RL: Engineered Total Disc Replacements in a Large Animal Model Recapitulate Native Disc Structure and Function. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020.

Zhang C, Schaer TP, Gullbrand SE, Jiang Z, Lau YK, Elliott DM, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Inflammatory Cytokine and Catabolic Enzyme Expression in a Goat Model of Intervertebral Disc Degeneration. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020.

Smith LJ, Iatridis JC, Dahia CL: Advancing Basic and Preclinical Spine Research: Highlights from the Fifth ORS PSRS International Spine Research Symposium. JOR Spine In press, 2020.

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Last updated: 01/27/2021
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