Lawrence B. Holzman, M.D.
Lawrence B. Holzman, M.D.
C. Mahlon Kline Professor of Medicine
Department: Medicine
Contact information
Renal-Electrolyte and Hypertension Division
322 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104-6140
322 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104-6140
Email:
lholzman@mail.med.upenn.edu
lholzman@mail.med.upenn.edu
Education:
B.A. (Biophysics)
University of Pennsylvania, 1980.
M.D.
UMDNJ - New Jersey Medical School, 1984.
Permanent linkB.A. (Biophysics)
University of Pennsylvania, 1980.
M.D.
UMDNJ - New Jersey Medical School, 1984.
Selected Publications
Garg P, Holzman LB: Podocytes: Gaining a foothold. Exp Cell Res 318(9): 955-53, May 2012 Notes: Epub 2012 Mar 7.Mallik L, Arif E, Sharma P, Rathore YS, Wong HN, Holzman LB, Ashish A, Nihalani D: Solution structure analysis of the cytoplasmic domain of podocyte protein NEPH1 using SWAXS (Small/Wide Angle X-ray Scattering). J Biol Chem 287(12): 9441-53, March 2012.
George B, Verma R, Soofi AA, Garg P, Zhang J, Park T, Giardino L, Ryzhova L, Johnstone DB, Wong H, Nihalani D, Salant DJ, Hanks SK, Curran T, Rastaldi MP, and Holzman LB: Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mice. J Clin Invest 122(2): 674-92, Feb 2012.
Bertuccio C, Veron D, Aggarwal PK, Holzman L, Tufro A: Vascular Endothelial Growth Factor Receptor 2 Direct Interaction with Nephrin Links VEGF-A Signals to Actin in Kidney Podocytes. J Biol Chem 286(46): 39933-44, Nov 2011 Notes: Epub 2011 Sep 21.
Zhdanova O, Srivastava S, Di L, Li Z, Tchelebi L, Dworkin S, Johnstone DB, Zavadil J, Chong MM, Littman DR, Holzman LB, Barisoni L, Skolnik EY: The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. Kidney Intl 80(7): 719-30, Oct 2011.
Kato H, Gruenwald A, Suh JH, Miner JH, Barisoni-Thomas L, Taketo MM, Faul C, Millar SE, Holzman LB, Susztak K: Wnt/{beta}-Catenin Pathway in Podocytes Integrates Cell Adhesion, Differentiation, and Survival. J Biol Chem 286(29): 26003-15, Jul 2011.
Inoki K, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Rüegg MA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, Wiggins RC, Guan K: mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest 121(6): 2181-96, Jun 2011.
Johnstone DB, Zhang J, George B, Léon C, Gachet C, Wong H, Parekh R, Holzman LB: Podocyte-specific deletion of Myh9 encoding non-muscle myosin heavy chain 2A predisposes mice to glomerulopathy. Mol Cell Biol Mar 2011 Notes: [Epub ahead of print]
George B, Holzman LB: Signaling from the Podocyte Intracellular Junction to the Actin Cytoskeleton. Seminars in Nephrology In Press 2011.
Chen S, Wassenhove-McCarthy D, Yamaguchi Y, Holzman L, van Kuppevelt TH, Orr AW, Funk S, Woods A, McCarthy K : Podocytes require the engagement of cell surface heparan sulfate proteoglycans for adhesion to extracellular matrices. Kidney Intl. (eds.). 78(11): 1088-99, Dec 2010 Notes: Epub 2010 May 12.