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Douglas C Wallace, PhD

Douglas C Wallace, PhD

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Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
The Center for Mitochondrial and Epigenomic Medicine at The Children's Hospital of Philadelphia Research Institute
The Colket Translational Research Building, Rm 6060
3501 Civic Center Boulevard
Philadelphia, PA 19104-4302
Office: 267-425-3034
Fax: 267-303-3615
B.S. (Genetics, Developmental Biology)
Cornell University, Ithaca, NY, 1968.
M. Phil. (Microbiology and Human Genetics)
Yale University, New Haven CT, 1972.
PhD (Microbiology and Human Genetics)
Yale University, New Haven CT, 1975.
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Selected Publications

Kokoszka JE, Waymire KG, Flierl A, Sweeney KM, Angelin A, MacGregor GR, Wallace DC: Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction. Biochimica et Biophysica Acta 1857(8): 1203-12, August 2016.

Potluri P, Procaccio V, Scheffler IE, Wallace DC: High throughput gene complementation screening permits identification of a mammalian mitochondrial protein synthesis (ρ-) mutant. Biochimica et Biophysica Acta 1857(8): 1336-43, August 2016.

Wallace DC: Genetics: Mitochondrial DNA in evolution and disease. Nature 535(7613): 498-500, July 2016.

Picard M, Wallace DC, Burelle Y: The rise of mitochondria in medicine. Mitochondrion 30: 105-116, July 2016.

Shen L, Diroma MA, Gonzalez M, Navarro-Gomez D, Leipzig J, Lott MT, van Oven M, Wallace DC, Muraresku CC, Zolkipli-Cunningham Z, Chinnery PF, Attimonelli M, Zuchner S, Falk MJ, Gai X: MSeqDR: A Centralized Knowledge Repository and Bioinformatics Web Resource to Facilitate Genomic Investigations in Mitochondrial Disease. Human Mutation 37(6): 540-08, June 2016.

Lin-Hendel EG, McManus MJ, Wallace DC, Anderson SA, Golden JA: Differential Mitochondrial Requirements for Radially and Non-radially Migrating Cortical Neurons: Implications for Mitochondrial Disorders. Cell Reports 15(2): 229-37, April 2016.

Picard M, McManus MJ, Gray JD, Nasca C, Moffat C, Kopinski P, Seifert E, McEwen BS, Wallace DC.: Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress. Proceedings of the National Academy of Sciences 112(48), Dec 2015 Notes: PMID: 26627253 PMCID: PMC4672794

Wallace DC: Mitochondrial DNA Variation in Human Radiation and Disease. Cell 163(1): 33-38, Sep 2015 Notes: PMID: 26406369.

Atilano SR, Malik D, Chwa M, Cáceres-Del-Carpio J, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N, Kenney MC.: Mitochondrial DNA variants can mediate methylation sttus of inflammation, angiogenesis and signaling genes. Human Molecular Genetics Aug 2015 Notes: PMID: 25964427; PMCID: PMC4512622.

Rivadeneira DB, Caino MC, Seo JH, Angelin A, Wallace DC, Languino LR, Altieri DC.: Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion. Sci Signal 8(389), Aug 2015 Notes: PMID: 26268608; PMCID: PMC4539531.

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Last updated: 10/27/2016
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