Douglas C Wallace, PhD

faculty photo
Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
The Center for Mitochondrial and Epigenomic Medicine at The Children's Hospital of Philadelphia Research Institute
The Colket Translational Research Building, Rm 6060
3501 Civic Center Boulevard
Philadelphia, PA 19104-4302
Office: 267-425-3034
Education:
B.S. (Genetics, Developmental Biology)
Cornell University, Ithaca, NY, 1968.
M. Phil. (Microbiology and Human Genetics)
Yale University, New Haven CT, 1972.
PhD (Microbiology and Human Genetics)
Yale University, New Haven CT, 1975.
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Selected Publications

Weisz Eliana D, Towheed Atif, Monyak Rachel E, Toth Meridith S, Wallace Douglas C, Jongens Thomas A: Loss of Drosophila FMRP leads to alterations in energy metabolism and mitochondrial function. Human molecular genetics 27(1): 95-106, Jan 2018.

Malicdan May Christine V, Vilboux Thierry, Ben-Zeev Bruria, Guo Jennifer, Eliyahu Aviva, Pode-Shakked Ben, Dori Amir, Kakani Sravan, Chandrasekharappa Settara C, Ferreira Carlos R, Shelestovich Natalia, Marek-Yagel Dina, Pri-Chen Hadass, Blatt Ilan, Niederhuber John E, He Langping, Toro Camilo, Taylor Robert W, Deeken John, Yardeni Tal, Wallace Douglas C, Gahl William A, Anikster Yair: A novel inborn error of the coenzyme Q10 biosynthesis pathway: cerebellar ataxia and static encephalomyopathy due to COQ5 C-methyltransferase deficiency. Human mutation 39(1): 69-79, Jan 2018.

Ortiz-González XR, Tintos-Hernández JA, Keller K, Li X,, Foley AR, Bharucha-Goebel DX, Kessler SK, Yum SW, Crino PB, He M, Wallace DC, Bönnemann CG.: Homozygous Boricua TBCK Mutation Causes Neurodegeneration and Aberrant Autophagy. Ann Neurol Dec 2017.

Sonney Sanjay, Leipzig Jeremy, Lott Marie T, Zhang Shiping, Procaccio Vincent, Wallace Douglas C, Sondheimer Neal: Predicting the pathogenicity of novel variants in mitochondrial tRNA with MitoTIP. PLoS computational biology 13(12): e1005867, Dec 2017.

Ortiz-González Xilma R, Tintos-Hernández Jesus A, Keller Kierstin, Li Xueli, Foley A Reghan, Bharucha-Goebel Diana X, Kessler Sudha K, Yum Sabrina W, Crino Peter B, He Miao, Wallace Douglas C, Bönnemann Carsten G: Homozygous Boricua TBCK Mutation Causes Neurodegeneration and Aberrant Autophagy. Annals of neurology Dec 2017.

Pei Liming, Wallace Douglas C: Mitochondrial Etiology of Neuropsychiatric Disorders. Biological psychiatry Nov 2017.

Zand Katayoun, Pham Ted D A, Li Jinfeng, Zhou Weiwei, Wallace Douglas C, Burke Peter J: Resistive flow sensing of vital mitochondria with nanoelectrodes. Mitochondrion 37: 8-16, Nov 2017.

Chalkia Dimitra, Singh Larry N, Leipzig Jeremy, Lvova Maria, Derbeneva Olga, Lakatos Anita, Hadley Dexter, Hakonarson Hakon, Wallace Douglas C: Association Between Mitochondrial DNA Haplogroup Variation and Autism Spectrum Disorders. JAMA psychiatry 74(11): 1161-1168, Nov 2017.

Kim Chul, Potluri Prasanth, Khalil Ahmed, Gaut Daria, McManus Meagan, Compton Shannon, Wallace Douglas C, Yadava Nagendra: An X-chromosome linked mouse model (Ndufa1S55A) for systemic partial Complex I deficiency for studying predisposition to neurodegeneration and other diseases. Neurochemistry international 109: 78-93, Oct 2017.

Wallace Douglas C: A Mitochondrial Etiology of Neuropsychiatric Disorders. JAMA psychiatry 74(9): 863-864, Sep 2017.

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Last updated: 10/17/2018
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