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David B. Roth, MD, PhD

David B. Roth, MD, PhD

faculty photo
Simon Flexner Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
6.036 Gates Building
3400 Spruce Street
Philadelphia, PA 19104-4283
Office: 215-615-6510
Fax: 215-662-4063
BA (Biochemistry)
Rice University, Houston TX, 1981.
MD (with High Honors)
Baylor College of Medicine, Houston TX, 1986.
PhD (Biochemistry)
Baylor College of Medicine, Houston TX, 1988.
Permanent link
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Description of Other Expertise

Panelist, Panel Discussion at Penn Medicine Advances: "Pathways Leading to Cures", Merion, PA, November, 2013

Selected Publications

Martina Mijušković, Yi-Fan Chou Vered Gigi, Cory R. Lindsay, Olga Shestova, Susanna M. Lewis, David B. Roth: Off target V(D)J recombination drives lymphomagenesis and is escalated by loss of the Rag2 C-terminus. Cell Reports 12: 1842-1852, Sept 2015 Notes: 10.1016/j.celrep.2015.08.034

Corrigan-Curay Jacqueline, O'Reilly Marina, Kohn Donald B, Cannon Paula M, Bao Gang, Bushman Frederic D, Carroll Dana, Cathomen Toni, Joung J Keith, Roth David, Sadelain Michel, Scharenberg Andrew M, von Kalle Christof, Zhang Feng, Jambou Robert, Rosenthal Eugene, Hassani Morad, Singh Aparna, Porteus Matthew H: Genome Editing Technologies: Defining a Path to Clinic. Molecular therapy: the journal of the American Society of Gene Therapy 23(5): 796-806, May 2015.

Wilson Melissa A, Morrissette Jennifer J D, McGettigan Suzanne, Roth David, Elder David, Schuchter Lynn M, Daber Robert D: What you are missing could matter: a rare, complex BRAF mutation affecting codons 599, 600, and 601 uncovered by next generation sequencing. Cancer genetics Jun 2014.

Vered Gigi, Susanna Lewis, Olga Shestova, Martina Mijušković, Ludovic Deriano, Wenzhao Meng, Eline T. Luning Prak and David B. Roth: RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of ‘alternative NHEJ’ Nucl. Acids Res. Apr 2014 Notes: In press, doi: 10.1093/nar/gku295.

Gigi V, Lewis S, Shestova O, Mijušković M, Deriano L, Meng W, Luning Prak ET, Roth DB: The "dispensable" C-terminus of RAG2 suppresses alternative NHEJ during repair of physiologic double-strand breaks in developing lymphocytes. Nucleic Acids Research 42(10): 6352-64, April 2014 Notes: doi: 10.1093/nar/gku25.

Lindsay CR, Roth DB: An unbiased method for detection of genome-wide off target effects in cell lines treated with zinc finger nucleases. Methods Mol Biol. 1114 F. Storici (eds.). Page: 353-69, 2014 Notes: doi: 10.1007/978-1-62703-761-7_2.

Deriano L, Roth DB: Modernizing the nonhomologous end joining repertoire: alternative and classical NHEJ share the stage. Annual Review of Genetics 47: 433-55, September 2013 Notes: DOI: 10.1146/annurev-genet-110711-155540.

Coussens MA, Wendland RL, Deriano L, Lindsay CR, Arnal SM, Roth DB: RAG2's Acidic Hinge Restricts Repair-Pathway Choice and Promotes Genomic Stability. Cell Reports 4(5): 870-878, Sept 2013.

Chaumeil J, Micsinai M, Ntziachristos P, Roth DB, Aifantis I, Kluger Y, Deriano L, Skok JA: The RAG2 C-terminus and ATM control RAG activity to limit the number of potential translocation substrates. Nature Communications June 2013.

Martina Mijuskovic, Stuart M. Brown, Zuojian Tang, Cory Lindsay, Efstratios Efstathiadis,Ludovic Deriano, David B. Roth: A streamlined Method for Detecting Structural Variants in Cancer Genomes by Short Read Paired-End Sequencing. Plos One 7(10), October 2012.

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Last updated: 11/04/2015
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