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David B. Roth, MD, PhD

David B. Roth, MD, PhD

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Simon Flexner Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
6.036 Gates Building
3400 Spruce Street
Philadelphia, PA 19104-4283
Office: 215-615-6510
Fax: 215-662-4063
Education:
BA (Biochemistry)
Rice University, Houston TX, 1981.
MD (with High Honors)
Baylor College of Medicine, Houston TX, 1986.
PhD (Biochemistry)
Baylor College of Medicine, Houston TX, 1988.
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Description of Other Expertise

Panelist, Panel Discussion at Penn Medicine Advances: "Pathways Leading to Cures", Merion, PA, November, 2013

Selected Publications

Vered Gigi, Susanna Lewis, Olga Shestova, Martina Mijušković, Ludovic Deriano, Wenzhao Meng, Eline T. Luning Prak and David B. Roth: RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of ‘alternative NHEJ’ Nucl. Acids Res. Apr 2014 Notes: In press, doi: 10.1093/nar/gku295.

Gigi V, Lewis S, Shestova O, Mijušković M, Deriano L, Meng W, Luning Prak ET, Roth DB: The "dispensable" C-terminus of RAG2 suppresses alternative NHEJ during repair of physiologic double-strand breaks in developing lymphocytes. Nucleic Acids Research 42(10): 6352-64, April 2014 Notes: doi: 10.1093/nar/gku25.

Lindsay CR, Roth DB: An unbiased method for detection of genome-wide off target effects in cell lines treated with zinc finger nucleases. Methods Mol Biol. 1114 F. Storici (eds.). Page: 353-69, 2014 Notes: doi: 10.1007/978-1-62703-761-7_2.

Deriano L, Roth DB: Modernizing the nonhomologous end joining repertoire: alternative and classical NHEJ share the stage. Annual Review of Genetics 47: 433-55, September 2013 Notes: DOI: 10.1146/annurev-genet-110711-155540.

Coussens MA, Wendland RL, Deriano L, Lindsay CR, Arnal SM, Roth DB: RAG2's Acidic Hinge Restricts Repair-Pathway Choice and Promotes Genomic Stability. Cell Reports 4(5): 870-878, Sept 2013.

Chaumeil J, Micsinai M, Ntziachristos P, Roth DB, Aifantis I, Kluger Y, Deriano L, Skok JA: The RAG2 C-terminus and ATM control RAG activity to limit the number of potential translocation substrates. Nature Communications June 2013.

Martina Mijuskovic, Stuart M. Brown, Zuojian Tang, Cory Lindsay, Efstratios Efstathiadis,Ludovic Deriano, David B. Roth: A streamlined Method for Detecting Structural Variants in Cancer Genomes by Short Read Paired-End Sequencing. Plos One 7(10), October 2012.

Deriano Ludovic, Chaumeil Julie, Coussens Marc, Multani Asha, Chou YiFan, Alekseyenko Alexander V, Chang Sandy, Skok Jane A, Roth David B: The RAG2 C terminus suppresses genomic instability and lymphomagenesis. Nature 471(7336): 119-23, Mar 2011.

Arnal Suzzette M, Holub Abigail J, Salus Sandra S, Roth David B: Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways. Nucleic acids research 38(9): 2944-54, May 2010.

Bischerour Julien, Lu Catherine, Roth David B, Chalmers Ronald: Base flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaks. Molecular and cellular biology 29(21): 5889-99, Nov 2009.

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Last updated: 08/13/2014
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