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David B. Roth, MD, PhD

David B. Roth, MD, PhD

faculty photo
Simon Flexner Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
6.036 Gates Building
3400 Spruce Street
Philadelphia, PA 19104-4283
Office: 215-615-6510
Fax: 215-662-4063
BA (Biochemistry)
Rice University, Houston TX, 1981.
MD (with High Honors)
Baylor College of Medicine, Houston TX, 1986.
PhD (Biochemistry)
Baylor College of Medicine, Houston TX, 1988.
Permanent link
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Description of Other Expertise

Panelist, Panel Discussion at Penn Medicine Advances: "Pathways Leading to Cures", Merion, PA, November, 2013

Selected Publications

Vered Gigi, Susanna Lewis, Olga Shestova, Martina Mijušković, Ludovic Deriano, Wenzhao Meng, Eline T. Luning Prak and David B. Roth: RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of ‘alternative NHEJ’ Nucl. Acids Res. Apr 2014 Notes: In press, doi: 10.1093/nar/gku295.

Coussens MA, Wendland RL, Deriano L, Lindsay CR, Arnal SM, Roth DB: RAG2's Acidic Hinge Restricts Repair-Pathway Choice and Promotes Genomic Stability. Cell Reports 4(5): 870-878, Sept 2013.

Martina Mijuskovic, Stuart M. Brown, Zuojian Tang, Cory Lindsay, Efstratios Efstathiadis,Ludovic Deriano, David B. Roth: A streamlined Method for Detecting Structural Variants in Cancer Genomes by Short Read Paired-End Sequencing. Plos One 7(10), October 2012.

Deriano Ludovic, Chaumeil Julie, Coussens Marc, Multani Asha, Chou YiFan, Alekseyenko Alexander V, Chang Sandy, Skok Jane A, Roth David B: The RAG2 C terminus suppresses genomic instability and lymphomagenesis. Nature 471(7336): 119-23, Mar 2011.

Arnal Suzzette M, Holub Abigail J, Salus Sandra S, Roth David B: Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways. Nucleic acids research 38(9): 2944-54, May 2010.

Bischerour Julien, Lu Catherine, Roth David B, Chalmers Ronald: Base flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaks. Molecular and cellular biology 29(21): 5889-99, Nov 2009.

Deriano Ludovic, Stracker Travis H, Baker Annalee, Petrini John H J, Roth David B: Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Molecular cell 34(1): 13-25, Apr 2009.

Stracker Travis H, Williams Bret R, Deriano Ludovic, Theunissen Jan W, Adelman Carrie A, Roth David B, Petrini John H J: Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability. Molecular and cellular biology 29(2): 503-14, Jan 2009.

Brandt Vicky L, Roth David B: Recent insights into the formation of RAG-induced chromosomal translocations. Advances in experimental medicine and biology 650: 32-45, 2009.

Wong Serre-Yu, Lu Catherine P, Roth David B: A RAG1 mutation found in Omenn syndrome causes coding flank hypersensitivity: a novel mechanism for antigen receptor repertoire restriction. Journal of immunology (Baltimore, Md. : 1950) 181(6): 4124-30, Sep 2008.

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Last updated: 06/05/2014
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