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David B. Roth, MD, PhD
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Emeritus Professor of Pathology and Laboratory Medicine
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Chair, Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania
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Member, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania
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Member, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania
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Founding Director, Precision Medicine Program, Penn Medicine
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Professor of Pathobiology, University of Pennsylvania School of Veterinary Medicine
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Department: Pathology and Laboratory Medicine
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Contact information
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6.036 Gates Building
3a 3400 Spruce Street
Philadelphia, PA 19104-4283
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3a 3400 Spruce Street
Philadelphia, PA 19104-4283
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Office: 215-615-6510
32 Fax: 215-662-4063
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32 Fax: 215-662-4063
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Links
127 "Former Penn professor and 1952 Penn Medicine grad who revolutionized cancer research has died", article in The Daily Pennsylvanian reporting on the death of Peter C. Nowell, MD
121 WHYY interview for The Pulse: POTUS: Precision Medicine Initiative will bring us closer to a cancer cure — NewsWorks
8e Penn Center for Precision Medicine
5c Roth Lab Website
1dd Online interview: "An interview with Dr. David Roth – Penn Medicine – Tackling the challenges of leveraging genomic data across both research and clinical settings at Penn Medicine", The Journal of Precision Medicine, March 2016
ef News Coverage: "Penn Cancer Center Looks to Expanded Gene Testing" Philadelphia Inquirer, August 9, 2013. b
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127 "Former Penn professor and 1952 Penn Medicine grad who revolutionized cancer research has died", article in The Daily Pennsylvanian reporting on the death of Peter C. Nowell, MD
121 WHYY interview for The Pulse: POTUS: Precision Medicine Initiative will bring us closer to a cancer cure — NewsWorks
8e Penn Center for Precision Medicine
5c Roth Lab Website
1dd Online interview: "An interview with Dr. David Roth – Penn Medicine – Tackling the challenges of leveraging genomic data across both research and clinical settings at Penn Medicine", The Journal of Precision Medicine, March 2016
ef News Coverage: "Penn Cancer Center Looks to Expanded Gene Testing" Philadelphia Inquirer, August 9, 2013. b
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Education:
21 7 BA 19 (Biochemistry) c
34 Rice University, Houston TX, 1981.
21 7 MD 1d (with High Honors) c
3f Baylor College of Medicine, Houston TX, 1986.
21 8 PhD 19 (Biochemistry) c
3f Baylor College of Medicine, Houston TX, 1988.
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Permanent link21 7 BA 19 (Biochemistry) c
34 Rice University, Houston TX, 1981.
21 7 MD 1d (with High Honors) c
3f Baylor College of Medicine, Houston TX, 1986.
21 8 PhD 19 (Biochemistry) c
3f Baylor College of Medicine, Houston TX, 1988.
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74 Panelist, Panel Discussion at Penn Medicine Advances: "Pathways Leading to Cures", Merion, PA, November, 2013
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Description of Other Expertise
3d Director, Penn Center for Precision Medicine74 Panelist, Panel Discussion at Penn Medicine Advances: "Pathways Leading to Cures", Merion, PA, November, 2013
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178 Hiemenz MC, Kadauke S, Lieberman DB, Roth DB, Zhao J, Watt CD, Daber RD, Morrissette JJ: Building a Robust Tumor Profiling Program: Synergy between Next-Generation Sequencing and Targeted Single-Gene Testing. PLoS One 11(4): e0152851, Apr 2016 Notes: doi: 10.1371/journal.pone.0152851. eCollection 2016.
148 Roth D: Young but Powerful: Penn Medicine’s Center for Personalized Diagnostics is on a mission to improve patient care using the power of genomics. The Pathologist(0316), 402, March 2016 Notes: https://thepathologist.com/issues/0316/young-but-powerful/
12b Lescale C, Abramowski V, Bedora-Faure M, Murigneux V, Vera G, Roth DB, Revy P, de Villartay JP, Deriano L: RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair. Nat Commun 7(10529), Feb 2016.
118 Wei S, Lieberman D, Morrissette JJ, Baloch ZW, Roth DB, McGrath C: Using "residual" FNA rinse and body fluid specimens for next-generation sequencing: An institutional experience. Cancer Cytopathol Dec 2015.
156 Martina Mijušković, Yi-Fan Chou Vered Gigi, Cory R. Lindsay, Olga Shestova, Susanna M. Lewis, David B. Roth: Off target V(D)J recombination drives lymphomagenesis and is escalated by loss of the Rag2 C-terminus. Cell Reports 12: 1842-1852, Sept 2015 Notes: 10.1016/j.celrep.2015.08.034 14
21a Corrigan-Curay Jacqueline, O'Reilly Marina, Kohn Donald B, Cannon Paula M, Bao Gang, Bushman Frederic D, Carroll Dana, Cathomen Toni, Joung J Keith, Roth David, Sadelain Michel, Scharenberg Andrew M, von Kalle Christof, Zhang Feng, Jambou Robert, Rosenthal Eugene, Hassani Morad, Singh Aparna, Porteus Matthew H: Genome Editing Technologies: Defining a Path to Clinic. Molecular therapy: the journal of the American Society of Gene Therapy 23(5): 796-806, May 2015.
16a Wilson Melissa A, Morrissette Jennifer J D, McGettigan Suzanne, Roth David, Elder David, Schuchter Lynn M, Daber Robert D: What you are missing could matter: a rare, complex BRAF mutation affecting codons 599, 600, and 601 uncovered by next generation sequencing. Cancer genetics Jun 2014.
158 Gigi V, Lewis S, Shestova O, Mijušković M, Deriano L, Meng W, Luning Prak ET, Roth DB: RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of 'alternative NHEJ' Nucleic Acids Research 42(10): 6352-64, April 2014 Notes: doi: 10.1093/nar/gku25.
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Selected Publications
19b Luskin MR, Carroll M, Lieberman D, Morrissette JJD, Zhao J, Crisalli L, Roth DB, Luger SM, Porter DL, Reshef D: Clinical utility of next-generation sequencing for oncogenic mutations in patients with acute myeloid leukemia undergoing allogenic stem cell transplantation. Biology of Blood and Marrow Transplantation 22: 1961-67, Sept 2016.178 Hiemenz MC, Kadauke S, Lieberman DB, Roth DB, Zhao J, Watt CD, Daber RD, Morrissette JJ: Building a Robust Tumor Profiling Program: Synergy between Next-Generation Sequencing and Targeted Single-Gene Testing. PLoS One 11(4): e0152851, Apr 2016 Notes: doi: 10.1371/journal.pone.0152851. eCollection 2016.
148 Roth D: Young but Powerful: Penn Medicine’s Center for Personalized Diagnostics is on a mission to improve patient care using the power of genomics. The Pathologist(0316), 402, March 2016 Notes: https://thepathologist.com/issues/0316/young-but-powerful/
12b Lescale C, Abramowski V, Bedora-Faure M, Murigneux V, Vera G, Roth DB, Revy P, de Villartay JP, Deriano L: RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair. Nat Commun 7(10529), Feb 2016.
118 Wei S, Lieberman D, Morrissette JJ, Baloch ZW, Roth DB, McGrath C: Using "residual" FNA rinse and body fluid specimens for next-generation sequencing: An institutional experience. Cancer Cytopathol Dec 2015.
156 Martina Mijušković, Yi-Fan Chou Vered Gigi, Cory R. Lindsay, Olga Shestova, Susanna M. Lewis, David B. Roth: Off target V(D)J recombination drives lymphomagenesis and is escalated by loss of the Rag2 C-terminus. Cell Reports 12: 1842-1852, Sept 2015 Notes: 10.1016/j.celrep.2015.08.034 14
21a Corrigan-Curay Jacqueline, O'Reilly Marina, Kohn Donald B, Cannon Paula M, Bao Gang, Bushman Frederic D, Carroll Dana, Cathomen Toni, Joung J Keith, Roth David, Sadelain Michel, Scharenberg Andrew M, von Kalle Christof, Zhang Feng, Jambou Robert, Rosenthal Eugene, Hassani Morad, Singh Aparna, Porteus Matthew H: Genome Editing Technologies: Defining a Path to Clinic. Molecular therapy: the journal of the American Society of Gene Therapy 23(5): 796-806, May 2015.
16a Wilson Melissa A, Morrissette Jennifer J D, McGettigan Suzanne, Roth David, Elder David, Schuchter Lynn M, Daber Robert D: What you are missing could matter: a rare, complex BRAF mutation affecting codons 599, 600, and 601 uncovered by next generation sequencing. Cancer genetics Jun 2014.
158 Gigi V, Lewis S, Shestova O, Mijušković M, Deriano L, Meng W, Luning Prak ET, Roth DB: RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of 'alternative NHEJ' Nucleic Acids Research 42(10): 6352-64, April 2014 Notes: doi: 10.1093/nar/gku25.
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