Steven Brem, M.D.

faculty photo
Professor CE of Neurosurgery
Director, Medical Student Education, Department of Neurosurgery, University of Pennsylvania
Medical Director, Center for Precision Surgery, Abramson Cancer Center, Perelman School of Medicine,
Senior Member, Neuro-Oncology Leadership Group, Abramson Cancer Center Perelman School of Medicine University of Pennsylvania
Member, Clinical Trials Scientific Review Monitoring Committee, Abramson Cancer Center
Department: Neurosurgery

Contact information
Department of Neurosurgery
PCAM South - Room 15-141
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: (215) 662-3487
Fax: 215-349-5534
Lab: n/a
Education:
BA (Magna Cum Laude)
Rutgers University, 1968.
MD (Medicine - Cum Laude)
Harvard Medical School, 1972.
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Description of Clinical Expertise

Complex Brain Tumor Surgery; Surgery of Intrinsic and Metastatic Brain Tumors; Pituitary Tumors; Acoustic Neuromas; Meningiomas; Skull Base Surgery; Brain Mapping; Health Outcomes; Evidence-Based Medicine;

Description of Research Expertise

Angiogenesis, Neuro-Oncology, Translational Drug Discovery, Personalized Medicine, Genomics, Biomarkers, Experimental Therapeutics, Brain Mapping, Health Outcomes, Brain Metastases, Clinical Guidelines, Clinical Pathways, Glioma Invasion, Targeted Brain Tumor Therapies, Connectomics, IL-6, cytokines, Viral Oncolytics,

Selected Publications

de Godoy LL, Chawla S, Brem S, Mohan S.: Taming Glioblastoma in "Real Time": Integrating Multimodal Advanced Neuroimaging/AI Tools Towards Creating a Robust and Therapy Agnostic Model for Response Assessment in Neuro-Oncology. Clin Cancer Res 29: 2588-2592, Jul 2023.

Richardson TE, Yokoda RT, Rashidipour O, Vij M, Snuderl M, Brem S, Hatanpaa KJ, McBrayer SK, Abdullah KG, Umphlett M, Walker JM, Tsankova NM.: Mismatch repair protein mutations in isocitrate dehydrogenase (IDH)-mutant astrocytoma and IDH-wild-type glioblastoma. Neurooncol Adv 5: vdad085, Jul 2023.

Sampson JH, Singh Achrol A, Aghi MK, Bankiewicz K, Bexon M, Brem S, Brenner A, Chandhasin C, Chowdhary S, Coello M, Ellingson BM, Floyd JR, Han S, Kesari S, Mardor Y, Merchant F, Merchant N, Randazzo D, Vogelbaum M, Vrionis F, Wembacher-Schroeder E, Zabek M, Butowski N.: Targeting the IL4 receptor with MDNA55 in patients with recurrent glioblastoma: Results of a phase IIb trial. Neuro Oncol 25: 1085-1097, Jun 2023.

Golkar E, Parker D, Brem S, Almairac F, Verma R.: CrOssing fiber Modeling in the Peritumoral Area using dMRI (COMPARI). bioRxiv May 2023.

Brem S, Henderson F Jr, Bagley SJ, Desai AS.: Commentary: Complementary and Alternative Medicine for Gliomas: Systematic Review and Critical Appraisal of Current Literature. Neurosurgery 92: e46-e47, Mar 2023.

Mandal AS, Brem S, Suckling J.: Brain network mapping and glioma pathophysiology. Brain Commun 5: fcad040, Feb 2023.

Riahi Samani Z, Parker D, Akbari H, Wolf RL, Brem S, Bakas S, Verma R.: Artificial intelligence-based locoregional markers of brain peritumoral microenvironment. Sci Rep 13: 963, Jan 2023.

Liau LM, Ashkan K, Brem S, Campian JL, Trusheim JE, Iwamoto FM, Tran DD, Ansstas G, Cobbs CS, Heth JA, Salacz ME, D'Andre S, Aiken RD, Moshel YA, Nam JY, Pillainayagam CP, Wagner SA, Walter KA, Chaudhary R, Goldlust SA, Lee IY, Bota DA, Elinzano H, Grewal J, Lillehei K, Mikkelsen T, Walbert T, Abram S, Brenner AJ, Ewend MG, Khagi S, Lovick DS, Portnow J, Kim L, Loudon WG, Martinez NL, Thompson RC, Avigan DE, Fink KL, Geoffroy FJ, Giglio P, Gligich O, Krex D, Lindhorst SM, Lutzky J, Meisel HJ, Nadji-Ohl M, Sanchin L, Sloan A, Taylor LP, Wu JK, Dunbar EM, Etame AB, Kesari S, Mathieu D, Piccioni DE, Baskin DS, Lacroix M, May SA, New PZ, Pluard TJ, Toms SA, Tse V, Peak S, Villano JL, Battiste JD, Mulholland PJ, Pearlman ML, Petrecca K, Schulder M, Prins RM, Boynton AL, Bosch ML.: Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A Phase 3 Prospective Externally Controlled Cohort Trial. JAMA Oncol 9: 112-121, Jan 2023.

de Godoy LL, Chawla S, Brem S, Wang S, O'Rourke DM, Nasrallah MP, Desai A, Loevner LA, Liau LM, Mohan S.: Assessment of treatment response to dendritic cell vaccine in patients with glioblastoma using a multiparametric MRI-based prediction model. J Neurooncol 2023.

Horbinski C, Nabors LB, Portnow J, Baehring J, Bhatia A, Bloch O, Brem S, Butowski N, Cannon DM, Chao S, Chheda MG, Fabiano AJ, Forsyth P, Gigilio P, Hattangadi-Gluth J, Holdhoff M, Junck L, Kaley T, Merrell R, Mrugala MM, Nagpal S, Nedzi LA, Nevel K, Nghiemphu PL, Parney I, Patel TR, Peters K, Puduvalli VK, Rockhill J, Rusthoven C, Shonka N, Swinnen LJ, Weiss S, Wen PY, Willmarth NE, Bergman MA, Darlow S.: NCCN Guidelines� Insights: Central Nervous System Cancers, Version 2.2022. J Natl Compr Canc Netw 2023.

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Last updated: 09/05/2023
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