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Perelman School of Medicine at the University of Pennsylvania Advanced Search

David Peter Cormode, PhD

David Peter Cormode, PhD

faculty photo
Assistant Professor of Radiology
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
3400 Spruce Street, 1 Silverstein
Philadelphia, PA 19104
Office: 215-615-4656
Education:
BA/MS (Chemistry)
St. Edmund Hall, University of Oxford, 2002.
PhD (Chemistry)
Balliol College, University of Oxford, 2006.
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Description of Research Expertise

Dr. Cormode's research focuses on the development of novel and multifunctional nanoparticle contrast agents for medical imaging applications. A current major area is the development of gold and bismuth nanoparticles as contrast agents for computed tomography (CT). The nanoparticles can be further modified to have a variety of additional functional properties, such as fluorescence, MRI contrast or therapeutic effects. Related areas of interest are novel computed tomography-based imaging methods, such as dual energy CT, spectral CT and iterative image reconstruction. These technologies are being applied for structural imaging and molecular imaging of the levels of specific cell types and proteins in vivo. These approaches provide enhanced characterization of cardiovascular diseases and cancers, which should allow improved selection of therapies and monitoring of response to treatments.

Undergraduates and master's students, as well as prospective graduate students and postdoctoral fellows are encouraged to email Dr. Cormode if interested in working in our lab.

Selected Publications

Allijn, Iris E.; Leong, Wei; Tang, Jun; Gianella, Anita; Mieszawska, Aneta J.; Fay, Francois; Ma, Ge; Russell, Stewart; Callo, Catherine B.; Gordon, Ronald E.; Korkmaz, Emine; Post, Jan Andries; Zhao, Yiming M.; Gerritsen, Hans C.; Thran, Axel; Proksa, Roland; Daerr, Heiner; Storm, Gert; Fuster, Valentin; Fisher, Edward A.; Fayad, Zahi A.; Mulder, Willem J.M.; Cormode, David P.: Gold nanocrystal labeled low density lipoprotein allows lipoprotein imaging from the macroscopic to subcellular level. ACS Nano 7(11): 9761-9770, 2013.

Duivenvoorden, Raphael; Tang, Jun; Cormode, David P.; Mieszawska, Aneta J.; Izquierdo-Garcia, D.; Ozcan, Canturk; Otten, Maarten J.; Zaidi, Neeha; Lobatto, Mark E.; van Rijs, Sarian M.; Priem, Bram; Kuan, Emma L.; Martel, Catherine; Hewing, Bernd; Sager, Hendrik; Nahrendorf, Matthias; Randolph, Gwendalyn J.; Stroes, Erik S. G.; Fuster, Valentin; Fisher, Edward A.; Fayad, Zahi A.; Mulder, Willem J. M. : A statin-loaded reconstituted high-density lipoprotein nanoparticle as a targeted therapy for atherosclerotic plaque inflammation. Nature Communications Page: in press, 2013.

Mieszawska, Aneta J.; Mulder, Willem J. M.; Fayad, Zahi A.; Cormode, David P. : Multifunctional gold nanoparticles for diagnosis and therapy of disease. Molecular Pharmaceutics 10: 831-847, 2013.

Galper, Merav W.; Saung, May T.; Fuster, Valentin: Roessl, Ewald; Thran, Axel; Proksa,Roland; Fayad, Zahi A.; Cormode, David P.: Effect of computed tomography scanning parameters on gold nanoparticle and iodine contrast. Investigative Radiology 47(8): 475-481, 2012.

van Tilborg, Geralda A. F.; Cormode, David P.; Jarzyna, Peter A.; van der Toorn, Annette; van der Pol, Susanne, M. A.; van Bloois, Louis; Storm, Gert; Mulder, Willem J. M.; de Vries, Helga E.; Dijkhuizen, Rick M.: Nanoclusters of iron oxide: effect of core composition on structure, biocompatibility and cell labeling efficacy. Bioconjugate Chemistry 23(5): 941–950, 2012.

Skajaa, Torjus; Cormode, David P.; Jarzyna, Peter A.; Delshad, Amanda; Blachford,Courtney; Barazza, Alessandra; Fisher, Edward A.; Gordon, Ronald E.; Fayad, Zahi A.; Mulder, Willem J. M.: The biological properties of iron oxide core high-density lipoprotein in experimental atherosclerosis. Biomaterials 32: 206-213, 2011.

Cormode, David P.; Skajaa, Gitte O.; Delshad, Amanda; Parker, Nicole; Jarzyna, Peter A.; Calcagno, Claudia; Galper, Merav W.; Skajaa, Torjus; Briley-Saebo, Karen C.; Bell, Heather M.; Gordon, Ronald E.; Fayad, Zahi A.; Woo, Savio L. C.; Mulder, Willem J. M.: Iron oxide nanoparticles with a fluorescent and tunable coating to allow multimodal imaging of nucleic acid delivery to different cell populations in the liver. Bioconjugate Chemistry 22: 353-361, 2011.

Cormode, David P.; Roessl, Ewald; Thran, Axel; Skajaa, Torjus; Gordon, Ronald E.; Schlomka, Jens-Peter; Fuster, Valentin; Fisher, Edward A.; Mulder, Willem J. M.; Proksa, Roland; Fayad, Zahi A.: Multicolor computed tomography and targeted gold nanoparticles for analysis of atherosclerotic plaque composition. Radiology 256: 675-676, 2010.

van Schooneveld, Matti M.; Cormode, David P.; Koole, Rolf; J. van Wijngaarden, J. Timon; Calcagno, Claudia; Skajaa, Torjus; Hilhorst, Jan; ‘t Hart, Dannis C.; Fayad, Zahi A.; Mulder, Willem J. M.; Meijerink, Andries.: Gold/silica nanoparticles coated with paramagnetic, fluorescent and poly(ethylene glycol)-modified lipids: a trimodal contrast agent. Contrast Media and Molecular Imaging 5, 4: 231-236, 2010.

Cormode, David P.; Skajaa, Torjus; van Schooneveld, Matti M.; Koole, Rolf; Jarzyna, Peter; Lobatto, Mark E.; Calcagno, Claudia; Barazza, Alessandra; Gordon, Ronald E.; Zanzonico, Pat; Fisher, Edward A.; Fayad, Zahi A. Mulder, Willem J. M.: Nanocrystal core high-density lipoproteins: A multimodal molecular imaging contrast agent platform. Nano Letters 8(11): 3715-3723, 2008.

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Last updated: 11/26/2013
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