1e
19
1
49
2
2
18
1b
1d
18
38
3b
1d
2 29
1d
25
David Peter Cormode, DPhil
78
3b
Professor of Radiology
28
7e
3
60
Member, Center for Translational Targeted Therapeutics and Nanomedicine
74
Member, Institute for Translational Medicine and Therapeutics
5c
Member, Penn Institute for Immunology
68
Member, Penn Center for Musculoskeletal Disorders
6f
Member, Center of Excellence in Environmental Toxicology
58
Member, Nano/Bio Interface Center
55
Member, Abramson Cancer Center
11
Department: Radiology
4
1
23
1f
Graduate Group Affiliations
8
a
b
1d
46
Contact information
58
4
3
3
1d
58
Hospital of the University of Pennsylvania
1f Department of Radiology
44 3400 Spruce Street, 1 Silverstein
Philadelphia, PA 19104
26
1f Department of Radiology
44 3400 Spruce Street, 1 Silverstein
Philadelphia, PA 19104
35
a9
12
18
Publications
23 a
3
2
29
4
b
1f
23 a
13
Education:
21 b BA/MS 16 (Chemistry) c
3e St. Edmund Hall, University of Oxford, 2002.
21 8 PhD 16 (Chemistry) c
3e Balliol College, University of Oxford, 2006.
c
3
3
3
3
8d
Permanent link21 b BA/MS 16 (Chemistry) c
3e St. Edmund Hall, University of Oxford, 2002.
21 8 PhD 16 (Chemistry) c
3e Balliol College, University of Oxford, 2006.
c
2 29
21
1e
1d
24
76
8
b7 Undergraduates and master's students, as well as prospective graduate students and postdoctoral fellows are encouraged to email Dr. Cormode if interested in working in our lab.
e 29
27
Description of Research Expertise
391 Dr. Cormode's research focuses on the development of novel and multifunctional nanoparticle contrast agents for medical imaging applications. A current major area is the development of gold and bismuth nanoparticles as contrast agents for computed tomography (CT). The nanoparticles can be further modified to have a variety of additional functional properties, such as fluorescence, MRI contrast or therapeutic effects. Related areas of interest are novel computed tomography-based imaging methods, such as dual energy CT, spectral CT and iterative image reconstruction. These technologies are being applied for structural imaging and molecular imaging of the levels of specific cell types and proteins in vivo. These approaches provide enhanced characterization of cardiovascular diseases and cancers, which should allow improved selection of therapies and monitoring of response to treatments.8
b7 Undergraduates and master's students, as well as prospective graduate students and postdoctoral fellows are encouraged to email Dr. Cormode if interested in working in our lab.
e 29
23
32a Hajfathalian, Maryam; de Vries, Christiaan R.; Hsu, Jessica C.; Amirshaghaghi, Ahmad; Dong, Yuxi C.; Ren, Zhi; Liu, Yuan; Huang, Yue; Li, Yong; Knight, Simon; Jonnalagadda, Pallavi; Zlitni, Aimen; Grice, Elizabeth; Bollyky, Paul L.; Koo, Hyun; Cormode, David P.: Theranostic gold-in-gold cage nanoparticles enable photothermal ablation and photoacoustic imaging in biofilm-associated infection models. Journal of Clinical Investigation 133(21): e168485, August 2023 Notes: Featured on the NIBIB website: https://www.nibib.nih.gov/news-events/newsroom/golden-solution-quickly-eliminates-bacterial-infections-no-antibiotics-required and Newsweek: https://www.newsweek.com/sugar-gold-nanoparticles-phototherapy-bacteria-antibiotics-1879397.
13d Hsu, Jessica C.; Tang, Zhongmin; Eremina, Olga; Sofias, Alexandros; Lammers, Twan; Lovell, Jonathan F.; Zavaleta, Cristina; Cai, Weibo; Cormode, David P.: Nanomaterial-based contrast agents. Nature Reviews Methods Primers 3(1): 30, April 2023.
19f Nieves, Lenitza M.; Dong, Yuxi C.; Rosario-Berríos, Derick N.; Mossburg, Katherine; Hsu, Jessica C.; Cramer, Gwendolyn M.; Busch, Theresa M.; Maidment, Andrew D. A.; Cormode, David P.: Renally excretable silver telluride nanoparticles as contrast agents for x-ray imaging. ACS Applied Materials and Interfaces 14(30): 34354-34364, July 2022.
1be Dong, Yuxi C.; Kumar, Ananyaa; Rosario-Berríos, Derick N.; Si-Mohamed, Salim; Hsu, Jessica C.; Nieves, Lenitza M.; Douek, Philippe; Noël, Peter B.; Cormode, David P. : Ytterbium nanoparticle contrast agents for conventional and spectral-photon counting CT and their applications for hydrogel imaging. ACS Applied Materials and Interfaces 14(34): 39274-39284, August 2022.
17d Kim, Johoon; Hong, Gwanui; Mazaleuskaya, Luda; Hsu, Jessica, C.; Rosario-Berrios, Derick N.; Grosser, Tilo; Cho-Park, Park F.; Cormode, David P.: Ultrasmall antioxidant cerium oxide nanoparticles for regulation of acute inflammation. ACS Applied Materials and Interfaces 13(51): 60852–60864, December 2021.
1a1 Hsu, Jessica, C.; Du, Yu; Sengupta, Arjun; Dong, Yuxi C.; Mossburg, Katherine J.; Bouché, Mathilde; Maidment, Andrew D. A.; Weljie, Aalim M.; Cormode, David P.: Effect of nanoparticle synthetic conditions on ligand coating integrity and subsequent nano-bio interactions. ACS Applied Materials and Interfaces 13(49): 58401-58410, November 2021.
1e0 Si-Mohamed, Salim; Sigovan, Monica; Hsu, Jessica C.; Chalabreysse, Lara; Garrivier, Thibaut; Tatard-Leitman, Valérie; Naha, Pratap C.; Carnaru, Miruna; Boussel, Loic; Cormode, David P.; Douek, Philippe. : In vivo molecular K-edge imaging of atherosclerotic plaque using photon-counting CT. Radiology 300: 98–107, July 2021 Notes: Was the subject of an editorial: Leiner, T. Radiology, 2021, 300, 108-109.
1b2 Bouché, Mathilde; Sheikh, Saad; Dong, Yuxi C.; Taing, Kimberly; Saxena, Deeksha; Hsu, Jessica C.; Chen, Minna. H; Salinas, Ryan D.; Song, Hongjun; Burdick, Jason, A.; Dorsey, Jay; Cormode, David P.: Radiation-responsive hydrogel for imaging and therapeutic delivery for glioblastoma treatment. ACS Biomaterials Science & Engineering 7(7): 3209-3320, July 2021.
2c
7
1d
1f
Selected Publications
24f Huang, Yue; Liu, Yuan; Pandey, Nil K.; Shah, Shrey; Simon-Soro, Aurea; Hsu, Jessica, C.; Ren, Zhi; Xiang, Zhenting; Kim, Dongyeop; Ito, Tatsuro; Oh, Min Jun; Buckley, Christine; Alawi, Faizan; Li, Yong; Smeets, Paul J. M.; Boyer, Sarah; Zhao, Xingchen; Joester, Derk; Zero, Domenick T.; Cormode, David P.; Koo, Hyun.: Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention. Nature Communications 14(1): 6087, September 2023 Notes: Co-corresponding author.32a Hajfathalian, Maryam; de Vries, Christiaan R.; Hsu, Jessica C.; Amirshaghaghi, Ahmad; Dong, Yuxi C.; Ren, Zhi; Liu, Yuan; Huang, Yue; Li, Yong; Knight, Simon; Jonnalagadda, Pallavi; Zlitni, Aimen; Grice, Elizabeth; Bollyky, Paul L.; Koo, Hyun; Cormode, David P.: Theranostic gold-in-gold cage nanoparticles enable photothermal ablation and photoacoustic imaging in biofilm-associated infection models. Journal of Clinical Investigation 133(21): e168485, August 2023 Notes: Featured on the NIBIB website: https://www.nibib.nih.gov/news-events/newsroom/golden-solution-quickly-eliminates-bacterial-infections-no-antibiotics-required and Newsweek: https://www.newsweek.com/sugar-gold-nanoparticles-phototherapy-bacteria-antibiotics-1879397.
13d Hsu, Jessica C.; Tang, Zhongmin; Eremina, Olga; Sofias, Alexandros; Lammers, Twan; Lovell, Jonathan F.; Zavaleta, Cristina; Cai, Weibo; Cormode, David P.: Nanomaterial-based contrast agents. Nature Reviews Methods Primers 3(1): 30, April 2023.
19f Nieves, Lenitza M.; Dong, Yuxi C.; Rosario-Berríos, Derick N.; Mossburg, Katherine; Hsu, Jessica C.; Cramer, Gwendolyn M.; Busch, Theresa M.; Maidment, Andrew D. A.; Cormode, David P.: Renally excretable silver telluride nanoparticles as contrast agents for x-ray imaging. ACS Applied Materials and Interfaces 14(30): 34354-34364, July 2022.
1be Dong, Yuxi C.; Kumar, Ananyaa; Rosario-Berríos, Derick N.; Si-Mohamed, Salim; Hsu, Jessica C.; Nieves, Lenitza M.; Douek, Philippe; Noël, Peter B.; Cormode, David P. : Ytterbium nanoparticle contrast agents for conventional and spectral-photon counting CT and their applications for hydrogel imaging. ACS Applied Materials and Interfaces 14(34): 39274-39284, August 2022.
17d Kim, Johoon; Hong, Gwanui; Mazaleuskaya, Luda; Hsu, Jessica, C.; Rosario-Berrios, Derick N.; Grosser, Tilo; Cho-Park, Park F.; Cormode, David P.: Ultrasmall antioxidant cerium oxide nanoparticles for regulation of acute inflammation. ACS Applied Materials and Interfaces 13(51): 60852–60864, December 2021.
1a1 Hsu, Jessica, C.; Du, Yu; Sengupta, Arjun; Dong, Yuxi C.; Mossburg, Katherine J.; Bouché, Mathilde; Maidment, Andrew D. A.; Weljie, Aalim M.; Cormode, David P.: Effect of nanoparticle synthetic conditions on ligand coating integrity and subsequent nano-bio interactions. ACS Applied Materials and Interfaces 13(49): 58401-58410, November 2021.
1e0 Si-Mohamed, Salim; Sigovan, Monica; Hsu, Jessica C.; Chalabreysse, Lara; Garrivier, Thibaut; Tatard-Leitman, Valérie; Naha, Pratap C.; Carnaru, Miruna; Boussel, Loic; Cormode, David P.; Douek, Philippe. : In vivo molecular K-edge imaging of atherosclerotic plaque using photon-counting CT. Radiology 300: 98–107, July 2021 Notes: Was the subject of an editorial: Leiner, T. Radiology, 2021, 300, 108-109.
1b2 Bouché, Mathilde; Sheikh, Saad; Dong, Yuxi C.; Taing, Kimberly; Saxena, Deeksha; Hsu, Jessica C.; Chen, Minna. H; Salinas, Ryan D.; Song, Hongjun; Burdick, Jason, A.; Dorsey, Jay; Cormode, David P.: Radiation-responsive hydrogel for imaging and therapeutic delivery for glioblastoma treatment. ACS Biomaterials Science & Engineering 7(7): 3209-3320, July 2021.
2c