David Peter Cormode, DPhil

faculty photo
Associate Professor of Radiology
Member, Center for Translational Targeted Therapeutics and Nanomedicine
Member, Institute for Translational Medicine and Therapeutics
Member, Nano/Bio Interface Center
Member, Penn Institute for Immunology
Member, Penn Center for Musculoskeletal Disorders
Member, Center of Excellence in Environmental Toxicology
Member, Abramson Cancer Center
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
3400 Spruce Street, 1 Silverstein
Philadelphia, PA 19104
Education:
BA/MS (Chemistry)
St. Edmund Hall, University of Oxford, 2002.
PhD (Chemistry)
Balliol College, University of Oxford, 2006.
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Description of Research Expertise

Dr. Cormode's research focuses on the development of novel and multifunctional nanoparticle contrast agents for medical imaging applications. A current major area is the development of gold and bismuth nanoparticles as contrast agents for computed tomography (CT). The nanoparticles can be further modified to have a variety of additional functional properties, such as fluorescence, MRI contrast or therapeutic effects. Related areas of interest are novel computed tomography-based imaging methods, such as dual energy CT, spectral CT and iterative image reconstruction. These technologies are being applied for structural imaging and molecular imaging of the levels of specific cell types and proteins in vivo. These approaches provide enhanced characterization of cardiovascular diseases and cancers, which should allow improved selection of therapies and monitoring of response to treatments.

Undergraduates and master's students, as well as prospective graduate students and postdoctoral fellows are encouraged to email Dr. Cormode if interested in working in our lab.

Selected Publications

Nieves, Lenitza M.; Dong, Yuxi C.; Rosario-Berríos, Derick N.; Mossburg, Katherine; Hsu, Jessica C.; Cramer, Gwendolyn M.; Busch, Theresa M.; Maidment, Andrew D. A.; Cormode, David P.: Renally excretable silver telluride nanoparticles as contrast agents for x-ray imaging. ACS Applied Materials and Interfaces 14(30): 34354-34364, July 2022.

Dong, Yuxi C.; Kumar, Ananyaa; Rosario-Berríos, Derick N.; Si-Mohamed, Salim; Hsu, Jessica C.; Nieves, Lenitza M.; Douek, Philippe; Noël, Peter B.; Cormode, David P. : Ytterbium nanoparticle contrast agents for conventional and spectral-photon counting CT and their applications for hydrogel imaging. ACS Applied Materials and Interfaces 14(34): 39274-39284, August 2022.

Kim, Johoon; Hong, Gwanui; Mazaleuskaya, Luda; Hsu, Jessica, C.; Rosario-Berrios, Derick N.; Grosser, Tilo; Cho-Park, Park F.; Cormode, David P.: Ultrasmall antioxidant cerium oxide nanoparticles for regulation of acute inflammation. ACS Applied Materials and Interfaces 13(51): 60852–60864, December 2021.

Hsu, Jessica, C.; Du, Yu; Sengupta, Arjun; Dong, Yuxi C.; Mossburg, Katherine J.; Bouché, Mathilde; Maidment, Andrew D. A.; Weljie, Aalim M.; Cormode, David P.: Effect of nanoparticle synthetic conditions on ligand coating integrity and subsequent nano-bio interactions. ACS Applied Materials and Interfaces 13(49): 58401-58410, November 2021.

Si-Mohamed, Salim; Sigovan, Monica; Hsu, Jessica C.; Chalabreysse, Lara; Garrivier, Thibaut; Tatard-Leitman, Valérie; Naha, Pratap C.; Carnaru, Miruna; Boussel, Loic; Cormode, David P.; Douek, Philippe. : In vivo molecular K-edge imaging of atherosclerotic plaque using photon-counting CT. Radiology 300: 98–107, July 2021 Notes: Was the subject of an editorial: Leiner, T. Radiology, 2021, 300, 108-109.

Bouché, Mathilde; Sheikh, Saad; Dong, Yuxi C.; Taing, Kimberly; Saxena, Deeksha; Hsu, Jessica C.; Chen, Minna. H; Salinas, Ryan D.; Song, Hongjun; Burdick, Jason, A.; Dorsey, Jay; Cormode, David P.: Radiation-responsive hydrogel for imaging and therapeutic delivery for glioblastoma treatment. ACS Biomaterials Science & Engineering 7(7): 3209-3320, July 2021.

Nieves, Lenitza M.; Hsu, Jessica, C.; Lau, Kristen C.; Maidment, Andrew D. A.; Cormode, David P.: Silver telluride nanoparticles as biocompatible and enhanced contrast agents for x-ray imaging: an in vivo breast cancer screening study. Nanoscale 13(1): 163-174, January 2021.

Huang, Yue; Liu, Yuan; Shah, Shrey; Kim, Dongyeop; Simon-Soro, Aurea; Ito, Tatsuro; Hajfathalian, Maryam; Li, Yong; Alawi, Faizon; Cormode, David P.; Koo, Hyun. : Bacterial pathogen targeting via bi-functional hybrid nanozyme triggered by biofilm microenvironment. Biomaterials 268: 120581, January 2021.

Naha, Pratap C.; Hsu, Jessica C.; Kim, Johoon; Shah, Shrey; Bouché, Mathilde; Si-Mohamed, Salim; Rosario-Berrios, Derick N.; Douek, Philippe; Hajfathalian, Maryam; Yasini, Parisa; Singh, Sanjay; Rosen, Mark A.; Morgan, Matthew A.; Cormode, David P. .: Dextran Coated Cerium Oxide Nanoparticles: A Computed Tomography Contrast Agent for Imaging the Gastrointestinal Tract and Inflammatory Bowel Disease. ACS Nano 14(8): 10187–10197, August 2020.

Hsu, Jessica; Nieves, Lenitza M.; Betzer, Oshra; Sadan, Tamar; Noël, Peter B.; Popovtzer, Rachela; Cormode, David P.: Nanoparticle contrast agents for X-ray imaging applications. WIREs Nanomedicine & Nanobiotechnology 12(6): e1642, May 2020 Notes: Highlighted in Advanced Science News: https://www.advancedsciencenews.com/combining-nanoparticles-with-new-x-ray-technologies-could-revolutionize-imaging-diagnosis/

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Last updated: 11/18/2022
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