David Peter Cormode, DPhil

faculty photo
Associate Professor of Radiology
Member, Center for Translational Targeted Therapeutics and Nanomedicine
Member, Institute for Translational Medicine and Therapeutics
Member, Nano/Bio Interface Center
Member, Penn Institute for Immunology
Member, Penn Center for Musculoskeletal Disorders
Member, Center of Excellence in Environmental Toxicology
Member, Abramson Cancer Center
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
3400 Spruce Street, 1 Silverstein
Philadelphia, PA 19104
BA/MS (Chemistry)
St. Edmund Hall, University of Oxford, 2002.
PhD (Chemistry)
Balliol College, University of Oxford, 2006.
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Description of Research Expertise

Dr. Cormode's research focuses on the development of novel and multifunctional nanoparticle contrast agents for medical imaging applications. A current major area is the development of gold and bismuth nanoparticles as contrast agents for computed tomography (CT). The nanoparticles can be further modified to have a variety of additional functional properties, such as fluorescence, MRI contrast or therapeutic effects. Related areas of interest are novel computed tomography-based imaging methods, such as dual energy CT, spectral CT and iterative image reconstruction. These technologies are being applied for structural imaging and molecular imaging of the levels of specific cell types and proteins in vivo. These approaches provide enhanced characterization of cardiovascular diseases and cancers, which should allow improved selection of therapies and monitoring of response to treatments.

Undergraduates and master's students, as well as prospective graduate students and postdoctoral fellows are encouraged to email Dr. Cormode if interested in working in our lab.

Selected Publications

Nieves, Lenitza M.; Hsu, Jessica, C.; Lau, Kristen C.; Maidment, Andrew D. A.; Cormode, David P.: Silver telluride nanoparticles as biocompatible and enhanced contrast agents for x-ray imaging: an in vivo breast cancer screening study. Nanoscale 13(1): 163-174, January 2021.

Huang, Yue; Liu, Yuan; Shah, Shrey; Kim, Dongyeop; Simon-Soro, Aurea; Ito, Tatsuro; Hajfathalian, Maryam; Li, Yong; Alawi, Faizon; Cormode, David P.; Koo, Hyun. : Bacterial pathogen targeting via bi-functional hybrid nanozyme triggered by biofilm microenvironment. Biomaterials 268: 120581, January 2021.

Naha, Pratap C.; Hsu, Jessica C.; Kim, Johoon; Shah, Shrey; Bouché, Mathilde; Si-Mohamed, Salim; Rosario-Berrios, Derick N.; Douek, Philippe; Hajfathalian, Maryam; Yasini, Parisa; Singh, Sanjay; Rosen, Mark A.; Morgan, Matthew A.; Cormode, David P. .: Dextran Coated Cerium Oxide Nanoparticles: A Computed Tomography Contrast Agent for Imaging the Gastrointestinal Tract and Inflammatory Bowel Disease. ACS Nano 14(8): 10187–10197, August 2020.

Hsu, Jessica; Nieves, Lenitza M.; Betzer, Oshra; Sadan, Tamar; Noël, Peter B.; Popovtzer, Rachela; Cormode, David P.: Nanoparticle contrast agents for X-ray imaging applications. WIREs Nanomedicine & Nanobiotechnology 12(6): e1642, May 2020 Notes: Highlighted in Advanced Science News: https://www.advancedsciencenews.com/combining-nanoparticles-with-new-x-ray-technologies-could-revolutionize-imaging-diagnosis/

Kim, Johoon; Silva, Alex B.; Hsu, Jessica C.; Maidment, Portia S. N.; Shapira, Nadav; Noël, Peter B.; Cormode, David P.: Radioprotective garment inspired biodegradable polymetal nanoparticles for enhanced CT contrast production. Chemistry of Materials 32(1): 381-391, January 2020.

Hsu, Jessica, C.; Cruz, Emma D.;Lau, Kristen C.; Bouché, Mathilde; Maidment, Andrew D. A.; Cormode, David P. : Renally-excretable and size-tunable silver sulfide nanoparticles for dual energy mammography or computed tomography. Chemistry of Materials 31(19): 7845-7854, October 2019.

Dong, Yuxi C.; Hajfathalian, Maryam; Maidment, Portia S. N.; Hsu, Jessica C.; Naha, Pratap C.; Si-Mohamed, Salim; Breuilly, Marine; Kim, Johoon; Chhour, Peter; Douek, Philippe; Litt, Harold I.; Cormode, David P.: Effect of gold nanoparticle size on their properties as contrast agents for computed tomography. Scientific Reports September 2019.

Bouché, Mathilde; Pühringer, Manuel; Iturmendi, Aitziber; Amirshaghaghi, Ahmad; Tsourkas, Andrew; Teasdale, Ian; Cormode, David P.: Activatable hybrid polyphosphazene-AuNP nanoprobe for ROS detection by bimodal PA/CT imaging. ACS Applied Materials and Interfaces 11(32): 28648-28656, August 2019.

Naha, Pratap C.; Liu, Yuan; Hwang, Geelsu; Huang, Yue; Gubara, Sarah; Jonnakuti, Venkata; Simon-Soro, Aurea; Kim, Dongyeop; Gao, Lizeng; Koo, Hyun.; Cormode, David P.: Dextran coated iron oxide nanoparticles as biomimetic catalysts for localized and pH-activated biofilm disruption. ACS Nano 13(5): 4960-4971, May 2019 Notes: Topic of a perspective article ‘Benoit, Danielle S. W.; Sims Jr., Kenneth R.; Fraser, David Nanoparticles for Oral Biofilm Treatments. ACS Nano, 2019, 13, 5, 4869-4875’

Hajfathalian, Maryam; Amirshaghaghi, Ahmad; Naha, Pratap C.; Chhour, Peter; Hsu, Jessica, C.; Douglas, Keely; Dong, Yuxi; Sehgal, Chandra M.; Tsourkas, Andrew; Neretina, Svetlana; Cormode, David P. : Wulff in a cage gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging. Nanoscale 10: 18749 – 18757, October 2018.

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Last updated: 06/22/2022
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