David Peter Cormode, PhD

faculty photo
Associate Professor of Radiology
Department: Radiology
Graduate Group Affiliations

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
3400 Spruce Street, 1 Silverstein
Philadelphia, PA 19104
Office: 215-615-4656
Education:
BA/MS (Chemistry)
St. Edmund Hall, University of Oxford, 2002.
PhD (Chemistry)
Balliol College, University of Oxford, 2006.
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Description of Research Expertise

Dr. Cormode's research focuses on the development of novel and multifunctional nanoparticle contrast agents for medical imaging applications. A current major area is the development of gold and bismuth nanoparticles as contrast agents for computed tomography (CT). The nanoparticles can be further modified to have a variety of additional functional properties, such as fluorescence, MRI contrast or therapeutic effects. Related areas of interest are novel computed tomography-based imaging methods, such as dual energy CT, spectral CT and iterative image reconstruction. These technologies are being applied for structural imaging and molecular imaging of the levels of specific cell types and proteins in vivo. These approaches provide enhanced characterization of cardiovascular diseases and cancers, which should allow improved selection of therapies and monitoring of response to treatments.

Undergraduates and master's students, as well as prospective graduate students and postdoctoral fellows are encouraged to email Dr. Cormode if interested in working in our lab.

Selected Publications

Hsu, Jessica, C.; Cruz, Emma D.;Lau, Kristen C.; Bouché, Mathilde; Maidment, Andrew D. A.; Cormode, David P. : Renally-excretable and size-tunable silver sulfide nanoparticles for dual energy mammography or computed tomography. Chemistry of Materials 31(19): 7845-7854, October 2019.

Dong, Yuxi C.; Hajfathalian, Maryam; Maidment, Portia S. N.; Hsu, Jessica C.; Naha, Pratap C.; Si-Mohamed, Salim; Breuilly, Marine; Kim, Johoon; Chhour, Peter; Douek, Philippe; Litt, Harold I.; Cormode, David P.: Effect of gold nanoparticle size on their properties as contrast agents for computed tomography. Scientific Reports September 2019.

Bouché, Mathilde; Pühringer, Manuel; Iturmendi, Aitziber; Amirshaghaghi, Ahmad; Tsourkas, Andrew; Teasdale, Ian; Cormode, David P.: Activatable hybrid polyphosphazene-AuNP nanoprobe for ROS detection by bimodal PA/CT imaging. ACS Applied Materials and Interfaces 11(32): 28648-28656, August 2019.

Naha, Pratap C.; Liu, Yuan; Hwang, Geelsu; Huang, Yue; Gubara, Sarah; Jonnakuti, Venkata; Simon-Soro, Aurea; Kim, Dongyeop; Gao, Lizeng; Koo, Hyun.; Cormode, David P.: Dextran coated iron oxide nanoparticles as biomimetic catalysts for localized and pH-activated biofilm disruption. ACS Nano 13(5): 4960-4971, May 2019 Notes: Topic of a perspective article ‘Benoit, Danielle S. W.; Sims Jr., Kenneth R.; Fraser, David Nanoparticles for Oral Biofilm Treatments. ACS Nano, 2019, 13, 5, 4869-4875’

Hajfathalian, Maryam; Amirshaghaghi, Ahmad; Naha, Pratap C.; Chhour, Peter; Hsu, Jessica, C.; Douglas, Keely; Dong, Yuxi; Sehgal, Chandra M.; Tsourkas, Andrew; Neretina, Svetlana; Cormode, David P. : Wulff in a cage gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging. Nanoscale 10: 18749 – 18757, October 2018.

Hsu, Jessica, C.; Naha, Pratap C.; Lau, Kristen C.; Chhour, Peter; Hastings, Renee; Moon, Brianna F.; Stein, Joel M.; Witschey, Walter R.; MacDonald, Elizabeth S.; Maidment, Andrew D. A.; Cormode, David P. : An all-in-one nanoparticle (AION) contrast agent for breast cancer screening with DEM-CT-MRI-NIRF imaging. Nanoscale 10: 17236 - 17248, October 2018.

Kim, Johoon; Bar-Ness, Daniel; Si-Mohamed, Salim; Coulon, Philippe; Blevis, Ira; Douek, Philippe; Cormode, David P.: Assessment of candidate elements for development of spectral photon-counting CT specific contrast agents. Scientific Reports Page: 12119, August 2018.

Liu, Yuan; Naha, Pratap C.; Hwang, Geelsu; Kim, Dongyeop; Huang, Yue; Simon-Soro, Aurea; Jung, Hoi-In; Ren, Zhi; Li, Yong; Gubara, Sarah; Alawi, Faizan; Zero, Domenick; Hara, Anderson T.; Cormode, David P.; Koo, Hyun: Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity. Nature Communications 9: 2920, July 2018.

Cormode, David P.; Si-Mohamed, Salim; Bar-Ness, Daniel; Sigovan, Monica; Naha, Pratap C.; Balegamire, Joelle; Lavenne, Franck; Coulon, Philippe; Roessl, Ewald; Bartels, Matthias; Rokni, Michal; Blevis, Ira; Boussel, Loic; Douek, Philippe: Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner. Scientific Reports 7: 4784, July 2017.

Chhour, Peter; Kim, Johoon; Benardo, Barbara; Tovar, Alfredo; Mian, Shaameen; Litt, Harold I.; Ferrari, Victor A.; Cormode, David P.: Effect of gold nanoparticle size and coating on labeling monocytes for CT tracking. Bioconjugate Chemistry 28(1): 260-269, January 2017 Notes: Part of a special issue: Interfacing Inorganic Nanoparticles with Biology.

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Last updated: 10/16/2019
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