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Aalim M. Weljie, Ph.D.

Aalim M. Weljie, Ph.D.

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Research Assistant Professor of Pharmacology
Department: Pharmacology

Contact information
10-113 Smilow Center for Translational Research
3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104
Office: 215-573-8085
Lab: 215-898-2220
Education:
B.Sc. (Chemistry; Certificate in Engineering)
Mount Allison University, 1996.
Ph.D. (Biochemistry)
University of Calgary, 2002.
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Description of Research Expertise

The Weljie Lab is located in the Department of Pharmacology at the University of Pennsylvania. Our lab is at the forefront of metabolomics technologies to examine biological problems in a translational medicine context.

Metabolomics is a growing sub-field of systems biology centered on the study of small biological molecules in biological fluids and tissues. Recent research suggests that analysis of metabolite concentrations in living systems is useful in disease diagnosis, prognosis, and predicting drug efficacy in a personalized medicine context.

Our focus is on developing analytical methods to advance research in translational medicine. There is an intrinsic link between metabolism and function of the innate circadian clock system in numerous organisms and disease states, but the exact mechanism by which the clock controls mammalian metabolism is poorly understood. Our work seeks to fill this knowledge gap along with identifying biomarkers of cancer and environmental health.

Selected Publications

Ho Victor W, Hamilton Melisa J, Dang Ngoc-Ha Thi, Hsu Brian E, Adomat Hans H, Guns Emma S, Weljie Aalim, Samudio Ismael, Bennewith Kevin L, Krystal Gerald: A low carbohydrate, high protein diet combined with celecoxib markedly reduces metastasis. Carcinogenesis Jul 2014.

Arjun Sengupta; Peeter Meerlo; Namni Goel; Matt Kayser; David Dinges; Morris Birnbaum; Ted Abel; Amita Sehgal; Aalim M Weljie: In Search of Metabolic Somnogens: A Unique Signature of Sleep Restriction from Blood in Rats. Metabolomics 2014: 10th Annual Meeting of the Metabolomics Society 2014 Notes: Oral.

Wu GD, Compher C, Chen EZ, Smith SA, Shah RD, Bittinger K, Chehoud C, Albenberg LG, Nessel L, Gilroy E, Star J, Weljie AM, Flint HJ, Metz DC, Bennett MJ, Li H, Bushman FD, Lewis J: Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production. Gut 2014 Notes: 10.1136/gutjnl-2014-308209.

Shearer J, Weljie AM: Biomarkers of Skeletal Muscle: Regulation, Metabolism, and Dysfunction. Metabolomics and Systems Biology in Human Health and Medicine. Jones OA (eds.). CABI, 2014.

Booth SC, Turner RJ, Weljie AM: Environmental Metabolomics Of Microbes. NMR Spectroscopy: A Versatile Tool for Environmental Research (eMagRes). Simpson MJ & Simpson AJ (eds.). 2014 Notes: ISBN: 978-1-118-61647-5.

Banoei MM, Donnelly SJ, Mickiewicz B, Weljie A, Vogel HJ, Winston BW: Metabolomics in critical care medicine, a new approach to biomarker discovery. Clinical and Investigative Medicine 37(6): E363-376, 2014.

Dang Ngoc-Ha T, Singla Arvind K, Mackay Emily M, Jirik Frank R, Weljie Aalim M: Targeted cancer therapeutics: biosynthetic and energetic pathways characterized by metabolomics and the interplay with key cancer regulatory factors. Current pharmaceutical design 20(15): 2637-47, 2014.

Ngoc-Ha T. Dang, Bo Young Ahn, Laszlo G. Boros, Donna Senger, Aalim M. Weljie: Targeting the distinct roles of acetyl-CoA carboxylase and fatty acid synthase in the fatty acid synthesis pathway of glioblastoma multiformes metabolism. Cold Spring Harbor Symposium: Metabolic Signaling & Disease: from Cell to Organism August 2013.

Athersuch Toby J, Malik Shahid, Weljie Aalim, Newton Jack, Keun Hector C: Evaluation of (1)H NMR Metabolic Profiling Using Biofluid Mixture Design. Analytical chemistry 85(14): 6674-81, Jun 2013.

Tambellini Nicolas P, Zaremberg Vanina, Turner Raymond J, Weljie Aalim M: Evaluation of extraction protocols for simultaneous polar and non-polar yeast metabolite analysis using multivariate projection methods. Metabolites 3(3): 592-605, 2013.

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Last updated: 12/02/2014
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