Aalim M. Weljie, Ph.D.

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Associate Professor of Pharmacology
Department: Pharmacology

Contact information
10-113 Smilow Center for Translational Research
3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104
Office: 215-573-8085
Lab: 215-898-2220
B.Sc. (Chemistry; Certificate in Engineering)
Mount Allison University, 1996.
Ph.D. (Biochemistry)
University of Calgary, 2002.
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Description of Research Expertise

The Weljie Lab is at the forefront of understanding systems level changes in metabolism in a translational medicine context, particularly related to sleep and circadian rhythms. We are in the Department of Systems Pharmacology and Translational Therapeutics within the Perelman School of Medicine at the University of Pennsylvania. Our primary approaches use metabolomics technologies such as mass spectrometry (MS) and nuclear magentic resonance spectroscopy (NMR) for steady state metabolite measurements, stable isotope tracing of substrate metabolites, and MS imaging approaches using desorption electrospray ionization (DESI)-MS.

Metabolomics is a growing sub-field of systems biology centered on the study of small biological molecules in biological fluids and tissues. Recent research demonstrates that analysis of metabolite concentrations in living systems is useful in disease diagnosis, prognosis, and predicting drug efficacy in a personalized medicine context.

There is an intrinsic link between metabolism and function of the innate circadian clock system in numerous organisms and disease states, but the exact mechanism by which the clock controls mammalian metabolism is poorly understood. Our work seeks to fill this knowledge gap along with a particular emphasis on understanding the relationship of the clock with sleep, cancer and environmental health.

Selected Publications

Mithani S, Yun S, Leete JJ, Guedes VA, Fink AM, Pattinson CL, Kim HS, Weljie A, Gill JM, Gehrman P.: Whole blood transcriptome analysis using RNA sequencing in individuals with insomnia disorder and good sleepers: a pilot study. Sleep Med 80: 1-8, Apr 2021.

Ch R, Rey G, Ray S, Jha PK, Driscoll PC, Dos Santos MS, Malik DM, Lach R, Weljie AM, MacRae JI, Valekunja UK, Reddy AB.: Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells. Nat Commun 12: 377, Jan 2021.

Cal-Kayitmazbatir S, Kulkoyluoglu-Cotul E, Growe J, Selby CP, Rhoades SD, Malik D, Oner H, Asimgil H, Francey LJ, Sancar A, Kruger WD, Hogenesch JB, Weljie A, Anafi RC, Kavakli IH.: CRY1-CBS binding regulates circadian clock function and metabolism. FEBS J 288: 614-639, Jan 2021.

Smith SA, Ogawa SA, Chau L, Whelan KA, Hamilton KE, Chen J, Tan L, Chen EZ, Keilbaugh S, Fogt F, Bewtra M, Braun J, Xavier RJ, Clish CB, Slaff B, Weljie AM, Bushman FD, Lewis JD, Li H, Master SR, Bennett MJ, Nakagawa H, Wu GD.: Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines. J Clin Invest 131: e133371, Jan 2021.

Bottalico LN, Weljie AM.: Cross-species physiological interactions of endocrine disrupting chemicals with the circadian clock. Gen Comp Endocrinol 301: 113650, Jan 2021.

Tang SY, Meng H, Anderson ST, Sarantopoulou D, Ghosh S, Lahens NF, Theken KN, Ricciotti E, Hennessy EJ, Tu V, Bittinger K, Weljie AM, Grant GR, FitzGerald GA.: Sex-dependent compensatory mechanisms preserve blood pressure homeostasis in prostacyclin receptor deficient mice. J Clin Invest Clin Invest, 2021.

Banoei MM, Vogel HJ, Weljie AM, Yende S, Angus DC, Winston BW.: Plasma lipid profiling for the prognosis of 90-day mortality, in-hospital mortality, ICU admission, and severity in bacterial community-acquired pneumonia (CAP). Crit Care 24: 461, Jul 2020.

Hao D, Sengupta A, Ding K, Ubeydullah ER, Krishnaiah S, Leighl NB, Shepherd FA, Seymour L, Weljie A.: Metabolites as Prognostic Markers for Metastatic Non-Small Cell Lung Cancer (NSCLC) Patients Treated with First-Line Platinum-Doublet Chemotherapy. Cancers (Basel) 12: 1926, Jul 2020.

Huangyang P, Li F, Lee P, Nissim I, Weljie AM, Mancuso A, Li B, Keith B, Yoon SS, Simon MC.: Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis. Cell Metab 31: 1032, May 2020.

Malik DM, Paschos GK, Sehgal A, Weljie AM.: Circadian and Sleep Metabolomics Across Species. J Mol Biol 432: 3578-3610, May 2020.

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Last updated: 06/24/2021
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