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Kumarasen Cooper, MB, ChB

Kumarasen Cooper, MB, ChB

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Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
HUP - Pathology and Laboratory Medicine
6.042 Founders
3400 Spruce Street
Philadelphia, PA 19104-4283
Office: 215-662-6538
Education:
BSc
University of Durban-Westville, 1974.
BSc (Hons)
University of Durban-Westville, 1975.
MBChB
University of Natal, 1980.
DPhil
University of Oxford, 1992.
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Description of Clinical Expertise

Jan 1982-Dec 1989/Dec 1992-Mar 1999: Routine Post Mortem and Surgical Pathology including use of Electron Microscopy, Immunofluorescence, Frozen Sections and Immunohistochemistry

May 1999-present: Routine general Surgical pathology sign out

Description of Research Expertise

Jan 1990-1992: As an Oxford Nuffield Research Fellow I joined Professor J O'D McGee's research laboratory at the John Radcliffe Hospital in Oxford. Using nonisotopic in-situ hybridisation (NISH) I conducted studies on Human Papillomavirus (HPV) infection of the uterine cervix using neoplastic specimens of paraffin embedded archival material from South Africa and Oxford. This led to the sequencing of a new HPV type from South Africa. In addition a novel method to determine the physical state of HPV using NISH was also described using confirmatory Southern blotting techniques. This work comprised the DPhil thesis.


Jan 1993-Mar 1999: In Johannesburg, I set up a molecular pathology laboratory utilising DNA in situ hybridisation, immunohistochemistry and PCR technology. This was funded by the SAIMR, MRC and NCA. Staffed with two full time senior technologists and one scientist, residents and attendings were involved in translational research. See abstracts and publications). I also set up the use of PCR (as an MMed project) for the investigation of lymphomas using gene rearrangements. This is now used as a routine investigation in this department. PCR technology for the detection of mycobacteria and HHV-8 is used for both research and diagnosis in paraffin sections. Several collaborative studies have been conducted with groups in the UK and USA (see publications).


May 1999-Present: In Burlington, Vermont, the Division of Experimental Pathology was created under my headship with two PhD scientists and two technicians. Pathology attendings and residents use this facility to engage in translational research. Collaborative projects have also been developed with Gyn Oncology, Otolaryngology and the Vermont Cancer Center. Aspects of my own research in HPV-associated cervical neoplasia continue to be investigated in this laboratory. These efforts are funded by the Vermont Cancer Center and Fletcher Allen Health Care.


An HPV Working Group comprising experts from various areas was also conceived with the view to educating high school teachers and children about the potential consequences of cervical HPV infections. Programs and presentation packages have been distributed with an enthusiastic reception.

Selected Publications

Drs. Cooper & Munjal: Human Papillomavirus Type Distribution in Invasive Cervical Cancers from Madhya Pradesh: Implications for Vaccination Programs in Central India International Jouranl of Gynecological Pathology. International Journal of Gynecological Pathology 2013 Notes: "In press"

Chao Ming Wei, Po Iris P, Laumbach Robert J, Koslosky John, Cooper Keith, Gordon Marion K: DEP induction of ROS in capillary-like endothelial tubes leads to VEGF-A expression. Toxicology 297(1-3): 34-46, Jul 2012.

Clarke Blaise A, Cooper Kumarasen: Identifying Lynch syndrome in patients with endometrial carcinoma: shortcomings of morphologic and clinical schemas. Advances in anatomic pathology 19(4): 231-8, Jul 2012.

Tucker Suzanne M, Cooper Kumarasen, Brownschidle Sara, Wilcox Rebecca: Embryonal (undifferentiated) sarcoma of the liver with peripheral angiosarcoma differentiation arising in a mesenchymal hamartoma in an adult patient. International journal of surgical pathology 20(3): 297-300, Jun 2012.

Brooks Erin Grace, Evans Mark Francis, Adamson Christine Stewart-Crawford, Peng Zhihua, Rajendran Vanitha, Laucirica Rodolfo, Cooper Kumarasen: In situ hybridization signal patterns in recurrent laryngeal squamous papillomas indicate that HPV integration occurs at an early stage. Head and neck pathology 6(1): 32-7, Mar 2012.

Iyer Anita, Thompson Lars, Cooper Kumarasen: Epithelioid haemangioendothelioma, mimicking prostatic adenocarcinoma. Histopathology 60(3): 522-4, Feb 2012.

Evans Mark Francis, Matthews Alisa, Kandil Dina, Adamson Christine Stewart-Crawford, Trotman Winifred Elizabeth, Cooper Kumarasen: Discrimination of 'driver' and 'passenger' HPV in tonsillar carcinomas by the polymerase chain reaction, chromogenic in situ hybridization, and p16(INK4a) immunohistochemistry. Head and neck pathology 5(4): 344-8, Dec 2011.

Conant Joanna L, Peng Zhihua, Evans Mark F, Naud Shelly, Cooper Kumarasen: Sarcomatoid renal cell carcinoma is an example of epithelial--mesenchymal transition. Journal of clinical pathology 64(12): 1088-92, Dec 2011.

Bell Karolyn B, Kida Masatoshi, Cooper Kumarasen: Histopathology sampling of radical prostatectomy specimens: representative or entire submission? Histopathology 59(5): 1013-4; author reply 1014, Nov 2011.

Hanson Joshua Anspach, Trent Jonathan C, Yang Dan, Cooper Kumarasen: Small-intestinal rhabdoid gastrointestinal stromal tumor (GIST): mutation analysis and clinical implications of a rare morphological variant. International journal of surgical pathology 19(5): 653-7, Oct 2011.

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Last updated: 03/05/2014
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