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Elizabeth McDonald, MD, PhD

Elizabeth McDonald, MD, PhD

faculty photo
Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
3400 Spruce Street, 1 Silverstein
Philadelphia, PA 19104
BA (Biochemistry (magna cum laude))
Harvard University, 1995.
PhD (Molecular Neuroscience)
Mayo Graduate School of Medicine, 2003.
Mayo Medical School, 2003.
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Perelman School of Medicine > Faculty > Search

Selected Publications

McDonald ES, Oustimov A, Weinstein SP, Synnestvedt M, Schnall MD, Conant EF: Effectiveness of digital breast tomosynthesis compared with digital mammography: Outcomes analysis from 3 years of breast cancer screening. JAMA Oncology 2(6): 737-43, Jun 2016 Notes: doi: 10.1001/jamaoncol.2015.5536 published online Feb 18, 2016.

McDonald ES, Mankoff D, Makvandi M, Chu W, Chu Y, Mach RH, Zeng C: Sigma-2 ligands and PARP inhibitors synergistically trigger cell death cancer cells. Biochem Biophys Res Commun 486(3): 788-795, May 2017.

Zuckerman S,Conant EF,Keller B,Weinstein S,McDonald ES.: Implementation of synthesized 2D mammography in a population-based digital breast tomosynthesis screening program. Radiology 28(1): 730-736, Dec 2016 Notes: Nominated for Scientific Paper of the Year AuntMinnie.com.

McDonald ES, Mankoff DA, Mach RH: Novel strategies for breast cancer imaging: new imaging agents to guide treatment. J Nuc Med 57: 69S-74S, Feb 2016 Notes: doi: 10.2967/jnumed.115.157925.

Cruz, L, McDonald, ES, Mick, R, Czerneicki, B: Anti-HER2 Th1 Response is Superior to Breast MRI in Response to Neoadjuvant Chemotherapy in Patients with HER2 Positive Breast Cancer. Ann Surg Oncol 24(4): 1057-1063, Apr 2017.

Pertuz S, McDonald ES, Weinstein SP, Conant EC, Kontos D: Fully-automated quantitative estimation of volumetric breast density from digital breast tomosynthesis images: Preliminary results and comparison with digital mammography and magnetic resonance imaging. Radiology 279(1): 65-74, 2016.

Lowenfeld, L, Zaheer, S, Oechsle, C, Fracol, M, Datta, J, Xu, S, Fitzpatrick, E, Roses, RE, Fisher, CS, McDonald, ES, Zhang, PJ, DeMichele, A, Mick, R, Koski, GK, Czerniecki, BJ. : Addition of Anti-Estrogen Therapy to Anti-HER2 Dendritic Cell Vaccination Improves Regional Nodal Immune Response and Pathologic Complete Response Rate in Patients with ERpos/HER2pos Early Breast Cancer. Oncoimmunology 2016 Notes: online 7/1/16.

Naha PC, Lau KC, Hsu JC, Hajfathalian M, Mian S, Chhour P, Uppuluri L, McDonald ES, Maidment AD, Cormode DP: Gold silver alloy nanoparticles (GSAN): an imaging probe for breast cancer screening with dual-energy mammography or computed tomography. Nanoscale 8(28): 13740-54, Jul 2016.

Makvandi, M, Xu, K, Lieberman, BP, Anderson, R, Effron, SS, Winters, H, Zeng, C, McDonald, ES, Pryma, DA, Greenberg, RA, Mach, RH.: A radiotracer strategy to quantify PARP-1 expression in vivo provides a biomarker that can enable patient selection for PARP inhibitor therapy. Cancer Research 76(15): 4516-24, Aug 2016.

McDonald ES, Clark A, Tchou J, Zhang, P, Freedman, G.: Clinical diagnosis and management of breast cancer. J Nuc Med 57: 9S-16S, Feb 2016 Notes: Featured on cover.

Mitsumori LM, McDonald ES, Neligan PC, Maki JH: Lower extremity MR Lymphangiography: Techniques and applications. Tech Vasc Inter Radiol 19(4): 262-272, Dec 2016.

Korhonen KE, Weinstein SP, McDonald ES, Conant EF: Strategies to increase cancer detection: Review of true-positive and false-negative results at digital breast tomosynthesis screening. Radiographics 36(7): 1954-1965, Nov-Dec 2016.

McDonald ES, Hammersley JA, Chou SS, Rahbar H, Scheel JR, Lee CI, Liu CL, Lehman CD, Partridge SC.: Performance of DWI as a Rapid Unenhanced Technique for Detecting Mammographically Occult Breast Cancer in Elevated-Risk Women with Dense Breasts. AJR Am Journal of Roentgenol 207(1): 205-16, Jul 2016.

Chen L, Ray S, Keller BM, Pertuz S, McDonald ES, Conant EF, Kontos D: The Impact of acquisition dose on quantitative breast density estimation with digital mammography: Results from ACRIN PA 4006. Radiology 280(3): 693-700, Sep 2016.

Conant EF, Keller BM, Pantalone L, Gastounioti A, McDonald ES, Kontos D: Agreement between breast percentage density estimations from standard-dose versus synthetic digital mammograms: Results from a large screening cohort using automated measures. Radiology Jan 2017 Notes: doi: 10.1148/radiol.2016161286 Epub ahead of print.

Chudgar, AV, Conant, EF, Weinstein, SP, Keller, BM, Synnestvedt, M, Yamartino, P, McDonald, ES: Digital Breast Tomosynthesis versus Digital Mammography alone Screen Detected Breast Cancers: Assessment of Disease Extent on Contrast-enhanced Magnetic Resonance Imaging. Clinical Radiology S0009-9260(17): 30078-8, Mar 2017.

McDonald ES, McCarthy AM, Akhtar A, Synnestvedt A, Schnall M, Conant EF: Baseline screening mammography: Performance of full field digital versus digital breast tomosynthesis. American Journal of Roentgenology 205(5): 1143-8, Nov 2015 Notes: doi: 10.2214/AJR.15.14406.

Rahbar, H, McDonald, ES, Lee, JM, Partridge, SC, Lee, CI.: How Can Advanced Imaging Be Used to Mitigate Potential Breast Cancer Overdiagnosis? Academic Radiology 23(6): 768-73, Jun 2016 Notes: doi: 10.1016/j.acra.2016.02.008.

Mahrooghy M, Ashraf A, Days D, Mcdonald ES, Rosen M, Mies C, Feldman M, Kontos D. : Pharmacokinetic tumor heterogeneity as a prognostic biomarker for classifying breast cancer recurrence risk IEEE Trans Biomed Eng. 62(6): 1585-94, Jun 2015 Notes: Featured on Cover.

Zuckerman, S, Weinstein, SW, McDonald, ES, Conant, E: A pictorial essay of synthetic tomosynthesis. American Journal of Roent (AJR) 2016 Notes: In press.

Makvandi M, Tilahun ED, Lieberman BP, Anderson RC, Zeng C, Xu K, Hou C, McDonald ES, Pryma DA,Mach RH: The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer. Biochem Biophys Res Commun (BBRC) 467(4): 1070-1075. Nov 2015 Notes: doi: 10.1016/j.bbrc.2015.09.157.

Mitsumori LM, McDonald ES, Wilson GJ, Neligan PC, Minoshima S, Maki JH: MR Lymphangiography: How I do it. J Magn Reson Imaging 42(6): 1465-77, Dec 2015 Notes: doi: 10.1002/jmri.24887.

McDonald ES, Schopp JG, Peacock S, DeMartini WB, Rahbar H, Lehman CD, Partridge SC: Diffusion-weighted MRI: association between patient characteristics and apparent diffusion coefficients of normal breast fibroglandular tissue at 3 T. AJR Am J Roentgenol 202(5): W496-502, May 2014 Notes: doi: 10.2214/AJR.13.11159.

Clark AS, McDonald E, Lynch MC, Mankoff D: Using nuclear medicine imaging in clinical practice: update on PET to guide treatment of patients with metastatic breast cancer. Oncology 28(5): 424-30, May 2014.

Doot RK, McDonald ES, Mankoff DA: Role of PET quantitation in the monitoring of cancer response to treatment: review of approaches and human clinical trials. Clin Transl Imaging 2(4): 295-303, Aug 2014.

Derakhshan JJ, McDonald ES, Siegelman ES, Schnall MD, Wehrli FW: Chemical shift artifact of the third kind: Implications for gradient-echo based contrast enhanced imaging. ISMRM 2016 Notes: Oral Presentation.

Mirzabeigi MN, McDonald ES, Chu MW, Fischer JP, Basta M, Kovach S, Wu LC, Serletti J, Kanchwala S: Operative management of locoregional cancer recurrence following post-mastectomy breast reconstruction-indications and outcomes. American Society for Reconstructive Microsurgery 2016 Notes: Oral Presentation.

Partridge SC, McDonald ES: Diffusion weighted magnetic resonance imaging of the breast: protocol optimization, interpretation, and clinical applications. Magn Reson Imaging Clin N Am 21(3): 601-624, Aug 2013 Notes: doi: 10.1016/j.mric.2013.04.007.

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Last updated: 04/29/2017
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