Elizabeth McDonald, MD, PhD

faculty photo
Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
3400 Spruce Street, 1 Silverstein
Philadelphia, PA 19104
Education:
BA (Biochemistry (magna cum laude))
Harvard University, 1995.
MD
Mayo Medical School, 2003.
PhD (Molecular Neuroscience)
Mayo Graduate School of Medicine, 2003.
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Selected Publications

McDonald, ES, Doot, RK, Pantel, AR, Farwell, MD, Mach, RH, Maxwell, KN, Mankoff, DA. : Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial. JAMA Oncology April 2020 Notes: doi: 10.1001/jamaoncol.2020.0334

McDonald, ES, Doot, RK, Young, AJ, Shubert, ES, Tchou, J, Pyrma, DA, Farwell, MD, Nayak, A, Ziober, A, Feldman, MD, DeMichele, A, Clark, AS, Shah, PD, Lee, H, Carlin, SD, Mach, RH, Mankoff, DA. : Breast Cancer 18F-ISO-1 Uptake as a Marker of Proliferation Status. Journal of Nuclear Medicine 61(5): 665-670, May 2020 Notes: doi: 10.2967/jnumed.119.232363.

Korhonen KE, Conant EF, Cohen EA, Synnestvedt M, McDonald ES, Weinstein SP.: Breast Cancer Conspicuity on Simultaneously Acquired Digital Mammographic Images versus Digital Breast Tomosynthesis Images. Radiology 292(1): 69-76, Jul 2019 Notes: doi: 10.1148/radiol.2019182027.

Conant, EF, Zuckerman, S, McDonald, ES, Weinstein, SP, Korhonen, K, Synnestvedt, M, Schnall, M, Hubbard, RA.: Five Consecutive Years of Screening with Digital Breast Tomosynthesis: Outcomes by Screening Year and Round Radiology 295(2): 285-293, May 2020 Notes: doi: 10.1148/radiol.2020191751.

Rahbar H, Zhang Z, Chenevert TL, Romanoff J, Kitsch AE, Hanna LG, Harvey SM, Moy L, DeMartini WB, Dogan B, Yang WT, Wang LC, Joe BN, Oh KY, Neal CH, McDonald ES, Schnall MD, Lehman CD, Comstock CE, Partridge SC.: Utility of Diffusion-weighted Imaging to Decrease Unnecessary Biopsies Prompted by Breast MRI: A Trial of the ECOG-ACRIN Cancer Research Group (A6702). Clin Cancer Res. 25(6): 1756-1765, March 2019 Notes: doi: 10.1158/1078-0432.

Chong A, Weinstein SP, McDonald ES, Conant EF.: Digital Breast Tomosynthesis: Concepts and Clinical Practice. Radiology 292(1): 1-14, Jul 2019 Notes: doi: 10.1148/radiol.2019180760.

McDonald ES, Ulaner GA.: Uses and Opportunities for Molecular Imaging in Patients with Breast Cancer. PET Clin. 2018 Jul;13(3):xi-xii. 13(3): xi-xii, Jul 2018 Notes: doi: 10.1016/j.cpet.2018.05.001.

Le, T. McDonald, ES, Isaac, G., Rosen, M. Dougherty, L.: Effect of Contrast Dose on Diagnostic Performance in DCE-MR Breast Imaging. Journal of Applied Clinical Medical Physics 2020 Notes: accepted

Mirzabeigi MN, Rhemtulla IA, Mcdonald ES, Sataloff DM, Kovach SJ, Wu LC, Serletti JM, Kanchwala S.: Locoregional Cancer Recurrence after Breast Reconstruction: Detection, Management, and Secondary Reconstructive Strategies. Plastic and Reconstructive Surgery 143(5): 1322-1330, May 2019 Notes: doi: 10.1097/PRS.0000000000005522.

Derakhshan JJ, McDonald ES, Siegelman ES, Schnall MD, Wehrli FW.: Characterizing and eliminating errors in enhancement and subtraction artifacts in dynamic contrast-enhanced breast MRI: Chemical shift artifact of the third kind. Magn Reson Med. 2018 Apr;79(4):2277-2289. 79(4): 2277-2289, April 2018 Notes: doi: 10.1002/mrm.26879.

Elmi A, McDonald ES, Mankoff D.: Imaging Tumor Proliferation in Breast Cancer: Current Update on Predictive Imaging Biomarkers. PET Clin. 2018 Jul;13(3):445-457. 13(3): 445-457, Jul 2018 Notes: doi: 10.1016/j.cpet.2018.02.007.

Hsu JC, Naha PC, Lau KC, Chhour P, Hastings R, Moon BF, Stein JM, Witschey WRT, McDonald ES, Maidment ADA, Cormode DP.: An all-in-one nanoparticle (AION) contrast agent for breast cancer screening with DEM-CT-MRI-NIRF imaging. Nanoscale 10(36): 17236-17248, September 2018 Notes: doi: 10.1039/c8nr03741h.

So A, De La Cruz LM, Williams AD, Bahng J, Liao G, McDonald ES, Fisher CS, Czerniecki BJ, Sataloff D, Tchou J.: The impact of preoperative magnetic resonance imaging and lumpectomy cavity shavings on re-excision rate in pure ductal carcinoma in situ-A single institution's experience. J Surg Oncol. 117(4): 558-566, March 2018 Notes: doi: 10.1002/jso.24890.

Chudgar, AV, Conant, EF, Weinstein, SP, Keller, BM, Synnestvedt, M, Yamartino, P, McDonald, ES: Assessment of disease extent on contrast-enhanced MRI in breast cancer detected at digital breast tomosynthesis versus digital mammography alone. Clinical Radiology 72(7):573-579. (7): 573-579, Jul 2017 Notes: doi: 10.1016/j.crad.2017.02.013.

Zuckerman SP, Maidment ADA, Weinstein SP, McDonald ES, Conant EF: Imaging with synthesized 2D mammography: differences, advantages, and pitfalls compared with digital mammography. AJR Am J Roentgenol 209(1): 222-229, Jul 2017 Notes: doi: 10.2214/AJR.16.17476.

McDonald ES, McCarthy AM, Weinstein SP, Schnall MD, Conant EF: BI-RADS category 3 comparison: probably benign category after recall from screening before and after implementation of digital breast tomosynthesis. Radiology. 2017 Dec;285(3):778-787. 285(3): 778-787, December 2017 Notes: doi: 10.1148/radiol.2017162837.

McDonald ES, Mankoff D, Makvandi M, Chu W, Chu Y, Mach RH, Zeng C: Sigma-2 ligands and PARP inhibitors synergistically trigger cell death cancer cells. Biochem Biophys Res Commun 486(3): 788-795, May 2017.

Zeng C, McDonald ES, Mach RH: Molecular probes for imaging the sigma-2 receptor: In vitro and in vivo imaging studies. Handb Exp Pharmacol 244: 309-330, Feb 2017 Notes: doi: 10.1007/164_2016_96.

Conant EF, Keller BM, Pantalone L, Gastounioti A, McDonald ES, Kontos D: Agreement between breast percentage density estimations from standard-dose versus synthetic digital mammograms: Results from a large screening cohort using automated measures. Radiology 283(3): 673-680, June 2017 Notes: doi: 10.1148/radiol.2016161286.

Cruz, L, McDonald, ES, Mick, R, Czerneicki, B: Anti-HER2 Th1 Response is Superior to Breast MRI in Response to Neoadjuvant Chemotherapy in Patients with HER2 Positive Breast Cancer. Ann Surg Oncol 24(4): 1057-1063, Apr 2017 Notes: doi: 10.1245/s10434-016-5651-z.

Pertuz S, McDonald ES, Weinstein SP, Conant EC, Kontos D: Fully-automated quantitative estimation of volumetric breast density from digital breast tomosynthesis images: Preliminary results and comparison with digital mammography and magnetic resonance imaging. Radiology 279(1): 65-74, 2016.

Mitsumori LM, McDonald ES, Neligan PC, Maki JH: Peripheral Magnetic Resonance Lymphangiography: Techniques and Applications. Tech Vasc Inter Radiol 19(4): 262-272, Dec 2016.

Korhonen KE, Weinstein SP, McDonald ES, Conant EF: Strategies to increase cancer detection: Review of true-positive and false-negative results at digital breast tomosynthesis screening. Radiographics 36(7): 1954-1965, Nov-Dec 2016.

Naha PC, Lau KC, Hsu JC, Hajfathalian M, Mian S, Chhour P, Uppuluri L, McDonald ES, Maidment AD, Cormode DP: Gold silver alloy nanoparticles (GSAN): an imaging probe for breast cancer screening with dual-energy mammography or computed tomography. Nanoscale 8(28): 13740-54, Jul 2016.

Makvandi, M, Xu, K, Lieberman, BP, Anderson, R, Effron, SS, Winters, H, Zeng, C, McDonald, ES, Pryma, DA, Greenberg, RA, Mach, RH.: A radiotracer strategy to quantify PARP-1 expression in vivo provides a biomarker that can enable patient selection for PARP inhibitor therapy. Cancer Research 76(15): 4516-24, Aug 2016.

Zuckerman S,Conant EF,Keller B,Weinstein S,McDonald ES.: Implementation of synthesized 2D mammography in a population-based digital breast tomosynthesis screening program. Radiology 28(1): 730-736, Dec 2016 Notes: Nominated for Scientific Paper of the Year AuntMinnie.com.

McDonald ES, Mankoff DA, Mach RH: Novel strategies for breast cancer imaging: new imaging agents to guide treatment. J Nuc Med 57: 69S-74S, Feb 2016 Notes: doi: 10.2967/jnumed.115.157925.

McDonald ES, Hammersley JA, Chou SS, Rahbar H, Scheel JR, Lee CI, Liu CL, Lehman CD, Partridge SC.: Performance of DWI as a Rapid Unenhanced Technique for Detecting Mammographically Occult Breast Cancer in Elevated-Risk Women with Dense Breasts. AJR Am Journal of Roentgenol 207(1): 205-16, Jul 2016.

Mirzabeigi MN, McDonald ES, Chu MW, Fischer JP, Basta M, Kovach S, Wu LC, Serletti J, Kanchwala S: Operative management of locoregional cancer recurrence following post-mastectomy breast reconstruction-indications and outcomes. American Society for Reconstructive Microsurgery 2016 Notes: Oral Presentation.

McDonald ES, Oustimov A, Weinstein SP, Synnestvedt M, Schnall MD, Conant EF: Effectiveness of digital breast tomosynthesis compared with digital mammography: Outcomes analysis from 3 years of breast cancer screening. JAMA Oncology 2(6): 737-743, Jun 2016.

Chen L, Ray S, Keller BM, Pertuz S, McDonald ES, Conant EF, Kontos D: The Impact of acquisition dose on quantitative breast density estimation with digital mammography: Results from ACRIN PA 4006. Radiology 280(3): 693-700, Sep 2016.

McDonald ES, Clark A, Tchou J, Zhang, P, Freedman, G.: Clinical diagnosis and management of breast cancer. J Nuc Med 57: 9S-16S, Feb 2016 Notes: Featured on cover.

McDonald ES, McCarthy AM, Akhtar A, Synnestvedt A, Schnall M, Conant EF: Baseline screening mammography: Performance of full field digital versus digital breast tomosynthesis. American Journal of Roentgenology 205(5): 1143-8, Nov 2015.

Rahbar, H, McDonald, ES, Lee, JM, Partridge, SC, Lee, CI.: How Can Advanced Imaging Be Used to Mitigate Potential Breast Cancer Overdiagnosis? Academic Radiology 23(6): 768-73, Jun 2016.

Makvandi M, Tilahun ED, Lieberman BP, Anderson RC, Zeng C, Xu K, Hou C, McDonald ES, Pryma DA,Mach RH: The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer. Biochem Biophys Res Commun (BBRC) 467(4): 1070-1075. Nov 2015.

Mitsumori LM, McDonald ES, Wilson GJ, Neligan PC, Minoshima S, Maki JH: MR Lymphangiography: How I do it. J Magn Reson Imaging 42(6): 1465-77, Dec 2015.

McDonald ES, Schopp JG, Peacock S, DeMartini WB, Rahbar H, Lehman CD, Partridge SC: Diffusion-weighted MRI: association between patient characteristics and apparent diffusion coefficients of normal breast fibroglandular tissue at 3 T. AJR Am J Roentgenol 202(5): W496-502, May 2014.

Clark AS, McDonald E, Lynch MC, Mankoff D: Using nuclear medicine imaging in clinical practice: update on PET to guide treatment of patients with metastatic breast cancer. Oncology 28(5): 424-30, May 2014.

Doot RK, McDonald ES, Mankoff DA: Role of PET quantitation in the monitoring of cancer response to treatment: review of approaches and human clinical trials. Clin Transl Imaging 2(4): 295-303, Aug 2014.

Partridge SC, McDonald ES: Diffusion weighted magnetic resonance imaging of the breast: protocol optimization, interpretation, and clinical applications. Magn Reson Imaging Clin N Am 21(3): 601-624, Aug 2013 Notes: doi: 10.1016/j.mric.2013.04.007.

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Last updated: 06/24/2020
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