Perelman School of Medicine/ Faculty Search/ Irving Nachamkin

Irving Nachamkin, DrPH, MPH

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Department: Pathology and Laboratory Medicine

Contact information

Department of Pathology and Laboratory Medicine
Room 7-046 Founders Pavilion (Lab Administration)
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104-4283

Office: (215) 662-3435
Fax: (215) 349-5090

Email:
NACHAMKI@MAIL.MED.UPENN.EDU

Publications

Search PubMed for articles

Links
Search PubMed for articles
Video about the Department of Pathology and Laboratory Medicine at Penn
Dept of Path & Lab Med Homepage
History of Clinical Microbiology at the University of Pennsylvania
Interview with the NY Times (May 9 2009) about the H1N1 Vaccine
Interview with the Washington Post about H1N1 Vaccines (Nov 28 2009)

Education:
B.Sc. (Medical Laboratory Science)
University of Bridgeport, Bridgeport, CT, 1975.
M.P.H. (Public Health Laboratory Practice)
University of North Carolina at Chapel Hill, Chapel Hill, NC, 1978.
Dr.P.H. (Public Health Microbiology)
University of North Carolina at Chapel Hill, Chapel Hill, NC, 1980.

Permanent link

Perelman School of Medicine > Faculty > Search

Description of Research Expertise

I have a special interest in Campylobacter and other gastrointestinal infections, with a focus on diagnostics, antibiotic resistance, and association of Campylobacter with Guillain-Barre Syndrome. We are also performing a genome wide association study of GBS (AIDP subtype) in collaboration with Profs Asbury, Price and Monos in the SOM. My lab is also involved in several collaborative studies with Prof Lautenbach in the SOM, examining risk factors for development of antimicrobial resistant infections in hospitalized patients and in the community. Other areas of interest include diagnostic microbiology, molecular diagnostic microbiology, cost-effectiveness of laboratory testing.

Description of Clinical Expertise

I am currently Director of the Division of Laboratory Medicine at the Hospital of the University of Pennsylvania. I also am Associate Director of the Clinical Microbiology Laboratory and Co-Director of the Pathology Residency Training Program at Penn Medicine. My areas of expertise include most areas of clinical microbiology. I have particular interests in the diagnosis of gastrointestinal infections.

Description of Other Expertise

I was Editor-in-Chief of Clinical Microbiology Reviews (2002-2012), one of the premier journals published by the American Society for Microbiology. In 2011, the journal was ranked #2 of 109 journals in Microbiology for Impact Factor (16.129) by ISI Citation Index.

Selected Publications

WHO Expert Panel on Campylobacteriosis: The global view of campylobacteriosis: report of expert consultation. World Health Organization. WHO, Geneva, 2013.

Lui, Z., Nachamkin, I., Edelstein, P.H., Lautenbach, E., Metlay, J.P.: Serotype emergence and genotype distribution of macrolide resistance in invasive Streptococcus pneumoniae in the post PCV7 era in the Philadelphia region. Antimicrob Agents Chemother 56: 743-50, 2012.

M'ikanatha NM, Dettinger LA, Perry A., Rogers P., Reynolds SM., Nachamkin, I.: Culturing stool specimens for Campylobacter spp., Pennsylvania, USA. Emerg. Infect. Dis. Page: 484-487, March 2012 Notes: commentary on this study in the same issue "Nonculture Diagnostic Tests for Enteric Diseases", Jones JF, Gerner-Smidt P, DOI: 10.3201/eid1803.111914.

Montone, K., LiVolsi, VA, Feldman, MD, Palmer, JN, Chiu, A., Lanza, D., Kennedy, DW, Loevner, L., Nachamkin, I: Fungal rhinosinusitis: a retrospective microbiologic and pathologic review of 400 patients at a single university center. Int. J. Otolarygol. 2012:684835: 1-9, 2012.

Han JH, Nachamkin I, Zaoutis TE, Coffin SE, Linkin DR, Fishman NO, Tolomeo P, Lautenbach E: Risk Factors for Gastrointestinal Tract Colonization with Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Species in Hospitalized Patients. Infect Cont Hosp Epidemiol 33: 1242-1245, Dec 2012.

Han J., Nachamkin I., Tolomeo P., Mao X., Bilker W., Lautenbach E.: Risk factors for efflux pump overexpression in fluoroquinolone-resistant Escherichia coli. J Infect Dis Page: epub ahead of print 9-10-2012, 2012.

Fitzgerald, C., Nachamkin, I.: Campylobacter and Arcobacter. Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington DC, 2011.

Lautenbach E, Fishman NO, Tolomeo P, Han X, Bilker WB, Wheeler M, Mao X, Nachamkin I, Metlay JP: Risk Factor for Prolonged Outpatient Fecal Colonization with Fluoroquinolone-Resistant Escherichia coli. Program and Abstracts of the 20th Annual Meeting of the Society for Healthcare Epidemiology of America (SHEA)/Fifth Decennial International Conference on Healthcare-Associated Infections, Atlanta, Georgia, March 18-22, 2010 March 2010.

M’ikanatha, N. M., Zhao, S., Bodeis-Jones, S., Medalla, F.M., A. Russell Localio, A.R., Nachamkin, I. : Comparison of fluoroquinolone and macrolide resistance in Campylobacter from Pennsylvania with national monitoring data. International Conference on Emerging Infectious Diseases, July 11-14, 2010, Atlanta, GA USA 2010.

Lautenbach, E., Tolomeo, P., Nachamkin, I., Hu, B., Zaoutis, T.E.: The Impact of Household Transmission on Duration of Outpatient Colonization with Methicillin-Resistant Staphylococcus aureus. Epidemiol. Infect. 138: 683-5, 2010.

Lautenbach, E., Metlay, J.P., Mai, X., Han, X., Fishman, N.O., Bilker, W.B., Tolomeo, P., Wheeler, M., Nachamkin, I.: The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates from hospitalized patients. Clin. Infect. Dis. 51(3): 280-5, August 2010.

Nachamkin, I.: Gastrointestinal Infections. Chapter 17. In, Hayden, R.T., Carroll, K., Tang, Y.W., Wolk, D. eds. Diagnostic Microbiology of the Immunocompromised Host. ASM Press, Washington, D.C. Page: 379- 390, 2009.

Lautenbach, E., Nachamkin, I., Hu, B., Fishman, N.O., Tolomeo, P., Prasad, P., Bilker, W.B., Zaoutis, T.E.: Surveillance Cultures for Detection of Methicillin-Resistant Staphylococcus aureus: Diagnostic Yield of Anatomic Sites and Comparison of Provider- and Patient-Collected Samples. Infect. Cont. Hosp. Epidemiol. 30(4): 380-382, 2009.

McGettigan, S.E., Hu, B., Andreacchio, K., Nachamkin, I., Edelstein, P.H. : Prevalence of CTX-M β-lactamases in Philadelphia. J. Clin. Microbiol. 47: 2970-4, 2009.

Nachamkin, I., S.V. Shadomy, A.P. Moran, N.J. Cox, C. Fitzgerald, H. Ung, A. Corcoran, J.K. Iskander, L.B. Schonberger, and R.T. Chen: Anti-ganglioside antibody induction by Swine (A/NJ/1976/H1N1) and other influenza vaccines: insights into vaccine-associated Guillain-Barre syndrome. J. Infect. Dis. 198: 226-233, 2008.

Nachamkin, I., Arzarte Barbosa, P., Ung, H., Lobato, C., Gonzalez Rivera, A., Rodriguez, P., Garcia Briseno, A., Maria Cordero, L., Garcia Perea, L., Carlos Perez, J., Ribera, P. Chico Aldama, G. Davila Gutierrez, L. Flores Sarnat, M. ruiz Garcia, M., Veitch, J., Fitzgerald, C., Cornblath, D., Pinto, M.R., Griffin, J.W., Willison, H.J., Asbury, A.K, McKhann, G.M.: Patterns of Guillain-Barre syndrome in children: results from a Mexican population. Neurology 69: 1665-1671, October 2007.

Hye, J.B., Nachamkin, I.: Campylobacter jejuni cst-II polymorphisms and Guillain-Barre syndrome. Neurology 68: 1633-4, 2007.

Perera, V., Nachamkin, I., Ung, H., Patterson, J., McConville, M., Coloe, P., Fry, B. : Molecular mimicry in Campylobacter jejuni: Role of the LOS core oligosaccharide in inducing anti-ganglioside antibodies FEMS Immunol. Med. Microbiol. 50(1): 27-36, 2007.