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Irving Nachamkin, DrPH, MPH

Irving Nachamkin, DrPH, MPH

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Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
Department of Pathology and Laboratory Medicine
Room 7-046 Founders Pavilion (Lab Administration)
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104-4283
Office: (215) 662-3435
Fax: (215) 349-5090
B.Sc. (Medical Laboratory Science)
University of Bridgeport, Bridgeport, CT, 1975.
M.P.H. (Public Health Laboratory Practice)
University of North Carolina at Chapel Hill, Chapel Hill, NC, 1978.
Dr.P.H. (Public Health Microbiology)
University of North Carolina at Chapel Hill, Chapel Hill, NC, 1980.
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Description of Research Expertise

I have a special interest in Campylobacter and other gastrointestinal infections, with a focus on diagnostics, antibiotic resistance, and association of Campylobacter with Guillain-Barre Syndrome. My lab is also involved in several collaborative studies with Prof Lautenbach in the SOM, examining risk factors for development of antimicrobial resistant infections in hospitalized patients and in the community. Other areas of interest include diagnostic microbiology, molecular diagnostic microbiology, cost-effectiveness of laboratory testing.

Description of Clinical Expertise

I am currently Director of the Division of Laboratory Medicine at the Hospital of the University of Pennsylvania. I also am Associate Director of the Clinical Microbiology Laboratory. My areas of expertise include most areas of clinical microbiology. I have particular interests in the diagnosis of gastrointestinal infections.

Selected Publications

Fitzgerald, C. and I. Nachamkin: Campylobacter and Arcobacter. Manual of Clinical Microbiology, 11th edition. ASM Press, Washington, DC, in press 2015.

Garrigan C, Attela A, Poly F, Guerry P, Nachamkin I: Distribution of Campylobacter jejuni capsular types, 2007-2012, Philadelphia, PA. Diag Microbiol Infect Dis 80: 204-206, August 2014.

Bartsch SM, Umsheid CA, Nachamkin I, Hamilton K, Lee BY.: Comparing the economic and health benefits of different approaches to diagnosing Clostridium difficult infection. Clin Microbiol Infect in press 2014.

Valerie C. Cluzet, MD, Jeffrey S. Gerber, MD, PhD, Irving Nachamkin, DrPH, MPH, Joshua Metlay, MD, PhD, Theoklis Zaoutis, MD, MSCE, Kathleen G. Julian, MD, David Royer, PhD, Darren R. Linkin, MD, MSCE, Susan E. Coffin, MD, MPH, David J. Margolis, MD, PhD, Judd E. Hollander, MD, Rakesh D. Mistry, MD, MS, Laurence J. Gavin, MD, Pam Tolomeo, MPH, Jacqueleen Wise, Mary K. Wheeler, MBE, Warren Bilker, PhD, Xiaoyan Han, MS, Baofeng Hu, Neil O. Fishman, MD, Ebbing Lautenbach, MD, MPH, MSCE and The CDC Prenvention Epicenters Program: Duration of Colonization with Methicillin-resistant Staphylococcus aureus and Determinants of More Rapid Clearance of Colonization. ID Week (IDSA), October 8-12, 2014, Philadelphia Page: Abstract #47276, October 2014.

Sloan, C., Bernard, S., Nachamkin, I.: Expectorated Sputum Cultures: Are They Ordered Appropriately and Do They Affect Management? 114th General Meeting of the American Society for Microbiology, Boston Page: 1747, May 2014.

Vegosen L., Breysse PN., Agmew J., Gray GC., Nachamkin I., Sheikh K., Kamel F., Silbvergeld E.: Occupational exposure to farm animals and antibody biomarkers of Campylobacter jejuni exposure and autoimmune peripheral neuropathy. American Public Health Association, Annual Meeting, Boston November 2013.

WHO Expert Panel on Campylobacteriosis: The global view of campylobacteriosis: report of expert consultation. World Health Organization. WHO, Geneva, 2013 Notes: ISBN 978 92 4 156460 1 July 9-11, 2012, Utrecht, Netherlands.

Nelson DB, Komaroff E, Nachamkin I, Haggerty CL, Dibble L, Mastrogiannis D, Liu C, Fredricks DN. : Relationship of selected bacterial vaginosis-associated bacteria to Nugent score bacterial vaginosis among urban women early in pregnancy. Sex. Transm. Dis. 40: 721-3, 2013.

Lui, Z., Nachamkin, I., Edelstein, P.H., Lautenbach, E., Metlay, J.P.: Serotype emergence and genotype distribution of macrolide resistance in invasive Streptococcus pneumoniae in the post PCV7 era in the Philadelphia region. Antimicrob Agents Chemother 56: 743-50, 2012.

Han JH, Nachamkin I, Zaoutis TE, Coffin SE, Linkin DR, Fishman NO, Tolomeo P, Lautenbach E: Risk Factors for Gastrointestinal Tract Colonization with Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Species in Hospitalized Patients. Infect Cont Hosp Epidemiol 33: 1242-1245, Dec 2012.

Han J., Nachamkin I., Tolomeo P., Mao X., Bilker W., Lautenbach E.: Risk factors for efflux pump overexpression in fluoroquinolone-resistant Escherichia coli. J Infect Dis 206: 1597-603, 2012.

M'ikanatha NM, Dettinger LA, Perry A., Rogers P., Reynolds SM., Nachamkin, I.: Culturing stool specimens for Campylobacter spp., Pennsylvania, USA. Emerg. Infect. Dis. 18: 484-487, 2012 Notes: commentary on this study in the same issue "Nonculture Diagnostic Tests for Enteric Diseases", Jones JF, Gerner-Smidt P.

Montone, K., LiVolsi, VA, Feldman, MD, Palmer, JN, Chiu, A., Lanza, D., Kennedy, DW, Loevner, L., Nachamkin, I: Fungal rhinosinusitis: a retrospective microbiologic and pathologic review of 400 patients at a single university center. Int. J. Otolarygol. Page: doi: 10.1155/2012/684835, Feb 2012.

Lautenbach, E., Tolomeo, P., Nachamkin, I., Hu, B., Zaoutis, T.E.: The Impact of Household Transmission on Duration of Outpatient Colonization with Methicillin-Resistant Staphylococcus aureus. Epidemiol. Infect. 138: 683-5, 2010.

Lautenbach, E., Metlay, J.P., Mai, X., Han, X., Fishman, N.O., Bilker, W.B., Tolomeo, P., Wheeler, M., Nachamkin, I.: The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates from hospitalized patients. Clin. Infect. Dis. 51(3): 280-5, August 2010.

M’ikanatha, N. M., Zhao, S., Bodeis-Jones, S., Medalla, F.M., A. Russell Localio, A.R., Nachamkin, I. : Comparison of fluoroquinolone and macrolide resistance in Campylobacter from Pennsylvania with national monitoring data. International Conference on Emerging Infectious Diseases, July 11-14, 2010, Atlanta, GA USA 2010.

Lautenbach E, Fishman NO, Tolomeo P, Han X, Bilker WB, Wheeler M, Mao X, Nachamkin I, Metlay JP: Risk Factor for Prolonged Outpatient Fecal Colonization with Fluoroquinolone-Resistant Escherichia coli. Program and Abstracts of the 20th Annual Meeting of the Society for Healthcare Epidemiology of America (SHEA)/Fifth Decennial International Conference on Healthcare-Associated Infections, Atlanta, Georgia, March 18-22, 2010 March 2010.

Nachamkin, I.: Gastrointestinal Infections. Chapter 17. In, Hayden, R.T., Carroll, K., Tang, Y.W., Wolk, D. eds. Diagnostic Microbiology of the Immunocompromised Host. ASM Press, Washington, D.C. Page: 379- 390, 2009.

McGettigan, S.E., Hu, B., Andreacchio, K., Nachamkin, I., Edelstein, P.H. : Prevalence of CTX-M β-lactamases in Philadelphia. J. Clin. Microbiol. 47: 2970-4, 2009.

Lautenbach, E., Nachamkin, I., Hu, B., Fishman, N.O., Tolomeo, P., Prasad, P., Bilker, W.B., Zaoutis, T.E.: Surveillance Cultures for Detection of Methicillin-Resistant Staphylococcus aureus: Diagnostic Yield of Anatomic Sites and Comparison of Provider- and Patient-Collected Samples. Infect. Cont. Hosp. Epidemiol. 30(4): 380-382, 2009.

Nachamkin, I., S.V. Shadomy, A.P. Moran, N.J. Cox, C. Fitzgerald, H. Ung, A. Corcoran, J.K. Iskander, L.B. Schonberger, and R.T. Chen: Anti-ganglioside antibody induction by Swine (A/NJ/1976/H1N1) and other influenza vaccines: insights into vaccine-associated Guillain-Barre syndrome. J. Infect. Dis. 198: 226-233, 2008.

Perera, V., Nachamkin, I., Ung, H., Patterson, J., McConville, M., Coloe, P., Fry, B. : Molecular mimicry in Campylobacter jejuni: Role of the LOS core oligosaccharide in inducing anti-ganglioside antibodies FEMS Immunol. Med. Microbiol. 50(1): 27-36, 2007.

Hye, J.B., Nachamkin, I.: Campylobacter jejuni cst-II polymorphisms and Guillain-Barre syndrome. Neurology 68: 1633-4, 2007.

Nachamkin, I., Arzarte Barbosa, P., Ung, H., Lobato, C., Gonzalez Rivera, A., Rodriguez, P., Garcia Briseno, A., Maria Cordero, L., Garcia Perea, L., Carlos Perez, J., Ribera, P. Chico Aldama, G. Davila Gutierrez, L. Flores Sarnat, M. ruiz Garcia, M., Veitch, J., Fitzgerald, C., Cornblath, D., Pinto, M.R., Griffin, J.W., Willison, H.J., Asbury, A.K, McKhann, G.M.: Patterns of Guillain-Barre syndrome in children: results from a Mexican population. Neurology 69: 1665-1671, October 2007.

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Last updated: 12/18/2014
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