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Irving Nachamkin, DrPH, MPH, D(ABMM) FAAM FIDSA

Irving Nachamkin, DrPH, MPH, D(ABMM) FAAM FIDSA

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Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
Department of Pathology and Laboratory Medicine
Room 7-046 Founders Pavilion (Lab Administration)
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104-4283
Office: (215) 662-3435
Fax: (215) 349-5090
B.Sc. (Medical Laboratory Science)
University of Bridgeport, Bridgeport, CT, 1975.
M.P.H. (Public Health Laboratory Practice)
University of North Carolina at Chapel Hill, Chapel Hill, NC, 1978.
Dr.P.H. (Public Health Microbiology)
University of North Carolina at Chapel Hill, Chapel Hill, NC, 1980.
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Description of Research Expertise

I have a special interest in Campylobacter and other gastrointestinal infections, with a focus on diagnostics, antibiotic resistance, and association of Campylobacter with Guillain-Barre Syndrome. My lab is also involved in several collaborative studies with Prof Lautenbach in the SOM, examining risk factors for development of antimicrobial resistant infections in hospitalized patients and in the community. Other areas of interest include diagnostic microbiology, molecular diagnostic microbiology, cost-effectiveness of laboratory testing.

Description of Clinical Expertise

I am currently Director of the Division of Laboratory Medicine at the Hospital of the University of Pennsylvania. I also am Associate Director of the Clinical Microbiology Laboratory. My areas of expertise include most areas of clinical microbiology. I have particular interests in the diagnosis of gastrointestinal infections.

Selected Publications

Bartsch SM, Umsheid CA, Nachamkin I, Hamilton K, Lee BY.: Comparing the economic and health benefits of different approaches to diagnosing Clostridium difficult infection. Clin Microbiol Infect 21(1): 77.e1-9, Jan 2015.

Fitzgerald C, Patrick M, Gonzalez A, Akin J, Polage C, Wymore K, Gillim-Ross L, Xavier K, Sadlowski J, Monahan J, Hurd S, Dahlberg S, Jerris R, Watson R, Santovenia M, Mitchell D, Harrison C, Tobin-D'Angelo M, DeMartino M, Pentella M, Leonard C, Razaq J, Jung C, Achong-Bowe R, Evans Y, Jain D, Juni B, Leano F, Robinson R, Smith S, Gittelman R, Garrigan C, Nachamkin I and Campylobacter Diagnostics Study Working Group : Multicenter evaluation of clinical diagnostic methods for detection and isolation of Campylobacter spp. from stool. J Clin Microbiol 54: 1209-1215, May 2016.

Kelly BJ, Lautenbach E, Nachamkin I, Coffin SE, Gerber JS, Fuchs B, Garrigan C, Han X, Bilker WB, Wise J, Tolomeo P, Han JH for the CDC Prevention Epicenters Program: Combined biomarkers discriminate a low likelihood of bacterial infection among surgical intensive care unit patients with suspected sepsis. Diag Microbiol Infect Dis 85: 109-15, May 2016.

Han J., Nachamkin I., Coffin S., Gerber J., Fuchs B., Garrigan C., Han X., Bilker W., Wise J., Tolomeo P., Lautenbach E. : Use of a combination biomarker algorithm to identify medical intensive care unit patients with suspected sepsis at very low likelihood of bacterial infection. Antimicrobial Agents Chemother 59(10): 6494-6500, Oct 2015.

Cluzet VC, Gerber JS, Nachamkin I, Metlay JP, Zaoutis TE, Davis MF, Julian KG, Royer D, Linkin DR, Coffin SE, Margolis DJ, Hollander JE, Mistry RD, Gavin LJ, Tolomeo P, Wise JA, Wheeler MK, Bilker WB, Han X, Hu B, Fishman NO, Lautenbach E.: Duration of Colonization and Determinants of Earlier Clearance of Colonization with Methicillin-Resistant Staphylococcus aureus. Clin Infect Dis 60(10): 1489-96, May 2015.

Sloan CE, Bernard S, Nachamkin I.: Appropriateness of Expectorated Sputum Cultures in the Hospital Setting. Diag Microbiol Infect Dis 83(1): 74-6, Sept 2015.

Alby K., Nachamkin I.: Gastrointestinal Infections. Microbiology Spectrum 4(3): doi:10.1128 /microbiolspec.DMIH2-0005-2015, 2016 Notes: also to be published in book chapter form, Diagnostic Microbiology of the Immunocompromised Host, 2nd edition (Hayden RT, Wolk DM, Karroll KC, Tang YW, eds, ASM Press, Washington DC 2016).

Cluzet VC., Lautenbach E., Nachamkin I., Cary MS., Fishman NO., Morales K., Linkin DR.: Risk factors for gyrA and parC mutations in Pseudomonas aeruginosa Infect Cont Hosp Epidemiol 36(4): 387-93, April 2015.

Fitzgerald, C. and I. Nachamkin: Campylobacter and Arcobacter. Chapter 56, Manual of Clinical Microbiology, 11th edition. ASM Press, Washington, DC, Page: 998-1012, May 2015.

Rattanaumpawan P., Nachamkin I., Bilker WB., Roy JA., Metlay JP., Zaoutis TE., Lautenbach E.: Risk factors for ambulatory urinary tract infections caused by high MIC-fluoroquinolone susceptible E. coli in women: results from a large case-control study. J Antimicrob Chemother 70(5): 1547-51, May 2015.

Misic A., David MF., Tyldsley AS, Hodkinson BP, Tolomeo P, Hu B., Nachamkin I, Lautenbach E, Morris DO., Grice EA.: The shared microbiota of humans and companion animals as evaluated from Staphylococcus carriage sites. Microbiome 3(2): doi: 10.1186/s40168-014-0052-7, Jan 2015.

Barbarin, A.M., Hu, B., Nachamkin, I., Levy, M.Z.: Colonization of Cimex lextularius with methicillin-resistant Staphylococcus aureus. Environ. Microbiol. 16(5): 1222-24, May 2014.

Sedrak M., Ziemba J., Murray D., Tsypenyuk B., Mincarelli D., Danoski D, Nachamkin I., Dine J., Myers JS.: Less is more: engaging residents and advanced practioners in a performance improvement project to reduce overutilization of daily labs at the Hospital of the University of Pennsylvania. 2015 ACGME Annual Educational Conference, San Diego, California, February 26 - March 1, 2015 2015.

Cluzet VC, Nachamkin I., Tolomeo P., Lautenbach E.: Prevalence and epidemiology of murpirocin resistance among those colonized with MRSA in the community. ID Week (IDSA, SHEA), Oct 8-12, 2014, Philadelphia Oct 2014.

Garrigan C, Attela A, Poly F, Guerry P, Nachamkin I: Distribution of Campylobacter jejuni capsular types, 2007-2012, Philadelphia, PA. Diag Microbiol Infect Dis 80: 204-206, August 2014.

Han J., Johnston B., Nachamkin I., Tolomeo P., Bilker W., Mao X., Clabots C., Johnson J., Lautenbach E.: Clinical and Molecular Epidemiology of Escherichia coli Sequence Type 131 (ST131) among Hospitalized Patients Colonized Intestinally with Fluoroquinolone-Resistant E. coli. Antimicrob Agents Chemother 58: 7003-6, Nov 2014.

Han JH, Nachamkin I, Tolomeo P, Mao X, Bilker WB, Lautenbach E: Temporal Changes in Resistance Mechanisms in Colonizing Escherichia coli Isolates with Reduced Susceptibility to Fluoroquinolones. Diag Microbiol Infect Dis 76: 491-496, 2013.

Han J., Bilker W., Nachamkin I., Zaoutis T., Coffin S., Linkin DR., Hu B., Tolomeo P., Fishman N., Lautenbach E.: The Effect of a Hospital-Wide Urine Culture Screening Intervention on the Incidence of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Species. Infect Control Hosp Epidemiol 34: 1160-1166, Nov 2013.

Han JH, Bilker WB, Nachamkin I, Tolomeo P, Mao X, Fishman NO, Lautenbach E: Impact of Antibiotic Use during Hospitalization on the Development of Gastrointestinal Colonization with Escherichia coli with Reduced Fluoroquinolone Susceptibility. Infect Control Hosp Epidemiol 34(10): 1070-1076, 2013.

Nachamkin I: Laboratory Developed Tests (LDTs). Pepper Talk (blog) Page: http://pathology.med.upenn.edu/department/blogs/ Dec 2015.

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Last updated: 05/27/2016
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