Ronald F. Coburn, M.D.

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Emeritus Professor of Physiology
Department: Physiology

Contact information
B204 Richards Building
University of Pennsylvania School of Medicine
Philadelphia, PA 19104-6085
Office: (215) 898-8069
Fax: (215) 573-5851

University of Michigan, 1953.
Northwestern University , 1954.
Northwestern University, 1957.
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Description of Research Expertise

My interests are pharmacomechanical and electromechanical coupling in airway smooth muscle, phosphoinositide metabolism and generation of second messengers, processing of neural inputs to airway smooth muscle and energy metabolism in vascular smooth muscle. Smooth muscle and neurons innervating smooth muscle are being studied using a combination of electrophysiological and tracer techniques, skinned smooth muscle and lipid biochemical technology.

Selected Publications

Sul D., Baron CB., Broome R., Coburn RF.: Smooth muscle length-dependent PI(4,5)P2 synthesis and paxillin tyrosine phosphorylation. American Journal of Physiology - Cell Physiology 281(1): C300-10, Jul 2001.

Baron CB., Tolan DR., Choi KH., Coburn RF.: Aldolase A Ins(1,4,5)P3-binding domains as determined by site-directed mutagenesis. Biochemical Journal 341 ( Pt 3): 805-12, Aug 1 1999.

Coburn R.F., Notafrancesco, K and Shuman, H: Focal adhesion complexes in unstimulated smooth muscle. Abstract for the Cell Biology meetings 1999.

Coburn, RF, DR Tolan, KH Choi and CB Baron: Aldolase A-inositol 1, 4, 5-trisphosphate binding domains. Memberane trafficking and the cytoskeleton: an integrated view. EMBO J 1999.

Sul, D, CB Baron and RF Coburn: Length-dependent inositol phospholipid metabolism in smooth muscle. Molec. Biol. Cell. 1999.

Chen H., Baron CB., Griffiths T 2nd., Greeley P., Coburn RF.: Effects of polyamines and calcium and sodium ions on smooth muscle cytoskeleton-associated phosphatidylinositol (4)-phosphate 5-kinase. Journal of Cellular Physiology 177(1): 161-73, Oct 1998.

Baron CB., Greeley P., Coburn RF.: Smooth muscle aldolase C-bound inositol 1,4,5-trisphosphate studied in vitro under physiological conditions. Biochimica et Biophysica Acta 1401(1): 81-92, Jan 2 1998.

Coburn RF, Notarfrancesco K, and Shuman H.: Focal adhesion complexes in unstimulated smooth muscle. Molec. Biol. Cell 9: 1549, 1998.

Coburn RF., Labelle EF., Griffiths T 2nd., Baron CB.: Smooth muscle sarcolemma-associated phospholipase C-beta 2; agonist-evoked translocation. Journal of Cellular Physiology 171(3): 271-83, Jun 1997.

Dey RD., Altemus JB., Rodd A., Mayer B., Said SI., Coburn RF.: Neurochemical characterization of intrinsic neurons in ferret tracheal plexus. American Journal of Respiratory Cell & Molecular Biology 14(3): 207-16, Mar 1996.

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Last updated: 08/22/2003
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