Irwin Lucki
Professor of Psychology in Psychiatry
Department: Psychiatry
Graduate Group Affiliations
Contact information
Department of Psychiatry
University of Pennsylvania
125 South 31st Street
Room 2204
Philadelphia, PA 19104-3403
University of Pennsylvania
125 South 31st Street
Room 2204
Philadelphia, PA 19104-3403
Office: 215-573-3305
Fax: 215-573-2041
Fax: 215-573-2041
Email:
lucki@mail.med.upenn.edu
lucki@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Pharmacological Sciences graduate group faculty webpage.
Neuroscience graduate group faculty webpage.
Neuropsychopharmacology Training Program
Search PubMed for articles
Pharmacological Sciences graduate group faculty webpage.
Neuroscience graduate group faculty webpage.
Neuropsychopharmacology Training Program
Education:
B.A. (Psychology)
University of Illinois, 1972.
M.A. (Psychology)
University of Iowa, 1976.
Ph.D. (Biopsychology)
University of Iowa, 1979.
B.A. (Psychology)
University of Illinois, 1972.
M.A. (Psychology)
University of Iowa, 1976.
Ph.D. (Biopsychology)
University of Iowa, 1979.
Post-Graduate Training
Postdoctoral Research Fellow, Psychopharmacology Training Program, Department of Psychiatry, University of Pennsylvania, 1979-1981.
Permanent linkPostdoctoral Research Fellow, Psychopharmacology Training Program, Department of Psychiatry, University of Pennsylvania, 1979-1981.
Description of Research Expertise
RESEARCH INTERESTS(1) Behavioral pharmacology; (2) Mechanism of action of antidepressant and antianxiety medications; (3) Stress neurobiology and psychiatric disorders
KEY WORDS:
Antidepressants; tranquilizers; stress; serotonin; microdialysis; knockouts; behavior
RESEARCH TECHNIQUES
Behavioral pharmacology in rats and mice; microdialysis measurement of extracellular concentrations of monoamines in conscious rats and mice; behavioral analysis of knockout mice; stereotaxic surgery; effects of brain lesions and neurotoxins on behavior; central drug administration; in vitro ligand binding; histology; radioimmunoassay; and HPLC analysis of brain monoamines
RESEARCH SUMMARY
Current studies focus on the role of specific neurotransmitters, such as serotonin (5-HT), in the behavioral effects of antidepressant and anxiolytic drugs. Animal models for depression and anxiety are used to evaluate the potential efficacy of different neurotransmitter and peptide receptors for clinical therapeutic effects, to identify brain regions associated with behavioral responses to drugs, and to construct and evaluate pharmacological models for improving the efficacy of psychiatric medications. The participation of central 5-HT neurotransmission in depression, anxiety and neuroendocrine regulation associated with behavioral stress is specifically being investigated. Microdialysis procedures are used to measure the release of neurotransmitters in discrete regions of awake freely-moving rats or mice. These studies provide information on the regulation of the release of neurotransmitters in different brain regions, determine environmental and behavioral conditions that alter the release of neurotransmitters, and measure the effects of drugs during behavioral performance. Finally, studies of different inbred mouse strains or knockout mice are examining genetic factors associated with complex behaviors and the behavioral effects of psychotherapeutic medications.
Selected Publications
Cohen, J.W., Louneva, N., Han, L.-Y., Hodes, G.E., Wilson, R.S., Bennett, D.A., Lucki, I. and Arnold, S.E. : Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95, NR1 and synaptopodin in the mouse brain. Synapse 2011.Carr GV, Bangasser DA, Bethea T, Young M, Valentino RJ, Lucki I.: Antidepressant-like effects of kappa-opioid receptor antagonists in wistar kyoto rats. Neuropsychopharmacology 35(3): 752-63, 2010.
Hodes, G.E., Hill-Smith, T.E. and Lucki, I. : Fluoxetine treatment induces dose dependent alterations in depression associated behavior and neural plasticity in female mice. Neuroscience Letters 484: 12-16, 2010.
Kilpatrick, M., Church, E., Danish, S., Stiefel, M., Jaggi, J., Halpern, C., Kerr, M., Maloney, E., Robinson, M. Lucki, I., Krizman-Grenda, E. and Baltuch, G. : Intracerebral microdialysis during deep brain stimulation surgery. Journal of Neuroscience Methods 190: 106-111, 2010.
Vucetic, Z., Totoki, K., Schoch, H., Whitaker, K.W., Hill-Smith, T., Lucki, I. and Reyes, T.M. : Early life protein restriction alters dopamine circuitry. Neuroscience 168: 359-370, 2010.
Carr, G.V. and Lucki, I. : Comparison of the kappa opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar-Kyoto and Sprague-Dawley rats. Psychopharmacology 210: 295-302, 2010.
Hodes GE, Hill-Smith TE, Suckow RF, Cooper TB, Lucki I.: Sex-specific effects of chronic fluoxetine treatment on neuroplasticity and pharmacokinetics in mice. J Pharmacol Exp Ther. 332(1): 266-73, 2010.
Valentino, R.J., Lucki, I. and Van Bockstaele, E. : Corticotropin-releasing factor in the dorsal raphe nucleus: Linking stress coping and addiction. Brain Research 1314C: 29-37, 2010.
Carr, G.V., Schechter, L.E. and Lucki, I. : Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacology 213: 499-507, 2010.
Balu DT, Hodes GE, Hill TE, Ho N, Rahman Z, Bender CN, Ring RH, Dwyer JM, Rosenzweig-Lipson S, Hughes ZA, Schechter LE, Lucki I.: Flow cytometric analysis of BrdU incorporation as a high-throughput method for measuring adult neurogenesis in the mouse. J Pharmacol Toxicol Methods 59(2): 100-107, 2009.
