My research focuses on PDT physics and external beam treatment planning. The first area involves the development of explicit and implicit dosimetry of PDT and light fluence rate calculation. The second area involves development of benchmark database for external beams (electron, photon, and proton) and image co-registrations. I have developed an integrated system for interstitial PDT light delivery and dosimetry for bulky tumors, including prostate and H&N cancers. A real-time treatment planning system is developed for intracavitory PDT utilizing an IR navigation system to track the real-time movement of the light source, including Pleural PDT. These techniques utilizes real-time feedback of light dosimetry to inform the 3D volumetric or 2D superficial light fluence calculations for PDT in heterogeneous environment. As a board certified Physicist in radiation oncology, I have been involved in the development of computational treatment planning system for external beams, medical imaging registration, radiation dose calculation, and patient motion monitoring.
Timothy C. Zhu, Michele M. Kim, Xing Liang, Jarod C. Finlay, and Theresa M. Busch: In-vivo singlet oxygen threshold doses for PDT. Photon Lasers Med in press 2015.
Timothy C. Zhu, Chris Bonnerup, Valdir C. Colussi, Marla L. Dowell, Jarod C. Finlay, Lothar Lilge, Thomas W. Slowey, Claudio Sibata: Absolute Calibration of Optical Power for PDT: Report of AAPM TG140. Med Phys 40(8): 081501 1-13, August 2013.
Xing Liang, Ken K. Wang, Timothy C. Zhu: Feasibility of interstitial diffuse optical tomography using cylindrical diffusing fiber for prostate PDT. Phys Med Biol 58: 3461-3480, May 2013.
Ayan AS, Lin H, Yeager, C, Deville C, McDonough J, Zhu TC, Anderson N, Bar Ad, V, Lu H-M, Both S: Should image rotation be addressed during routine cone-beam CT quality assurance? Phys Med Biol 58(4): 1059-1073, January 2013.
Timothy C. Zhu: Dosimetry in Pleural Photodynamic Therapy. J Natl Compr Canc Netw. 10: S60-4, October 2012.
Andreea Dimofte, Jarod C. Finlay, Xing Liang, and Timothy C. Zhu (senior author): Determination of optical properties in heterogeneous turbid media using a cylindrical diffusing fiber. Physics in medicine and biology 57: 6025-46, October 2012.
Jiajian Shen, James M. Metz, Timothy C Zhu, Joseph Panetta, Jarod C Finlay, Meng Xu-Welliver, John P Plastaras, Voichita Bar Ad, Stefan Both: Dosimetric Consequences of Pancreatic Tumor Motion when Predtermined Treatment Margins are Employed during Intensity-Modulated Radiation Therapy. J. BOUR 17(4): 526-532, July 2012.
Yida Hu and Timothy C. Zhu: Backscatter Correction Factor for Megavoltage Photon Beam. Med Phys 38(10): 5563-5568, October 2011.
Harry Quon, Jarod Finlay, Keith Cengel, Timothy Zhu,
Bert O’Malley Jr., Gregory Weinstein: Transoral robotic photodynamic therapy for the oropharynx. Photodianosis Photodyn Ther. 8(1): 64-7, March 2011.
Timothy C Zhu, E Ishmael Parsai, Colin G Orton: PDT is better than alternative therapies such as brachtherapy, electron beams, or low-energy x rays for the treatment of skin cancers. Med Phys 38(3): 1133-1135, March 2011.
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Last updated: 01/09/2015
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