My research focuses on PDT physics and external beam treatment planning. The first area involves the development of explicit and implicit dosimetry of PDT and light fluence rate calculation. The second area involves development of benchmark database for external beams (electron, photon, and proton) and image co-registrations. I have developed an integrated system for interstitial PDT light delivery and dosimetry for bulky tumors, including prostate and H&N cancers. A real-time treatment planning system is developed for intracavitory PDT utilizing an IR navigation system to track the real-time movement of the light source, including Pleural PDT. These techniques utilizes real-time feedback of light dosimetry to inform the 3D volumetric or 2D superficial light fluence calculations for PDT in heterogeneous environment. As a board certified Physicist in radiation oncology, I have been involved in the development of computational treatment planning system for external beams, medical imaging registration, radiation dose calculation, and patient motion monitoring.
Dr. Zhu is an ABR and ABMP board certified medical physicist. He is the associate director of PDT Physics, in charge of all PDT related physics aspect of PDT clinical protocols. His specialty includes external beam radiation therapy, IGRT/IMRT, PDT, small field dosimetry, MU calculations, TSE/TBI, in-vivo radiation dosimetry, and Machine QA.
Michele M. Kim, Rozhin Penjweini, Nathan R. Gemmell, Israel
Veilleux, Aongus McCarthy, Gerald S. Buller, Robert H. Hadfield, Brian
Wilson, Timothy C. Zhu (senior author): A comparison of singlet oxygen explicit dosimetry (SOED) and singlet
oxygen luminescence dosimetry (SOLD) for Photofrin-mediated photodynamic
therapy. Cancers 8: 109, December 2016 Notes: DOI:10.3390/Cancers8120109.
Yihong Ong and Timothy C Zhu (senior author): An analytic function for predicting light fluence rate of circular fields on a semi-infinite turbid medium. Opt. Exp. 24(23): 26261-26281, November 2016 Notes: DOI:10.1364/OE.24.026261.
Peng Wang, Jochin Cammin, Francesca Biscello, Timothy D. Solberg, James E. McDonough, Timothy C. Zhu, David Menichelli, Boon-Keng Kevin Teo: Proton Computed Tomography Using a 1D Silicon Diode Array. Med Phys 43(10): 5758-5767, October 2016 Notes: DOI:10.1118/1.4963221.
Michele M. Kim, Rozhin Penjweini, Xing Liang, Timothy C. Zhu (senior author): Explicit macroscopic singlet oxygen modeling for benzoporphyrin
derivative monoacid ring A (BPD)-mediated photodynamic therapy. J Photobiol Photochem B 164: 312-322, October 2016 Notes: DOI:10.1016/j.jphotobiol.2016.09.031.
Rozhin Penjweini, Michele M Kim, Baochang Liu, Timothy C Zhu (senior author): Evaluation of the 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide (HPPH) mediated photodynamic therapy by macroscopic singlet oxygen modeling. J Biophotonics Page: Pubished online 9/22/2016, Sept 2016 Notes: DOI 10.1002/jbio.201600121.
Haixia Qiu, Michele M. Kim, Rozhin Penjweini, Timothy C. Zhu (senior author): Macroscopic singlet oxygen modeling for dosimetry of Photofrin-mediated photodynamic therapy- an in-vivo study. J Biomed. Opt. 21(8): 088002, August 2016.
N. R. Gemmell, A. McCarthy, M.M. Kim, I. Veilleux, T. C. Zhu, G.S. Buller, B. C. Wilson, R. H. Hadfield: A compact Fiber Optic Probe-based Singlet Oxygen Luminescence Detection System. J Biophotonics Page: published on line 7/25/2016, July 2016 Notes: DOI:10.1002/jbio.201600078.
Peter H. Ahn, Harry Quon, Bert W. O’Malley, Gregory Weinstein, Ara Chalian, Kelly Malloy, Joshua H. Atkins, Thomas Sollecito, Martin Greenberg, Sally McNulty, Alexander Lin, Timothy C. Zhu, Jarod C. Finlay, Keith Cengel, Virginia Livolsi, Michael Feldman, Rosemarie Mick, Theresa M. Busch: Toxicities and Early Outcomes in a Phase 1 Trial of Photodynamic Therapy for Premalignant and Early Stage Head and Neck Tumors. oral Oncology 55: 37-42, Feb 2016 Notes: doi: 10.1016/j.oraloncology.2016.01.013.
Haixia Qiu, Michele M. Kim, Rozhin Penjweini, Jarod C. Finlay, Theresa M. Busch, Tianhao Wang, Wenshen Guo, Keith A. Cengel, Charles B. Simone II, Eli Glatstein, Timothy C. Zhu (senior author): A comparison of dose metrics to predict local tumor control for photofrin-mediated photodynamic therapy. Photochem. Photobiol. Page: in press, 2016.
Rozhin Penjweini, Baochang Liu, Michele M. Kim, Timothy C. Zhu (senior author): Explicit dosimetry for 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) mediated photodynamic therapy: macroscopic singlet oxygen modeling. J. Biomed. Opt. 20(12): 128003, Dec 2015 Notes: doi: 10.1117/1.JBO.20.12.128003.
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Last updated: 12/06/2016
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