Department of Radiation Oncology

Timothy C. Zhu

faculty photo

Timothy C. Zhu, Ph.D.

Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
University of Pennsylvania
3400 Civic Center Blvd, TRC W 4th floor
Philadelphia, PA 19104
Office: 215-662-4043
Fax: 215-615-5600
Education:
BS (Electric Engineering)
Fudan University, Shanghai, China , 1984.
M.Sc. (Physics)
Brown University , 1987.
M.Sc. (Engineering)
Brown University , 1988.
Ph.D. (Physics)
Brown University, 1991.
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Description of Research Expertise

RESEARCH INTERESTS:
My research focuses on PDT physics, in-vivo dosimetry, and external beam treatment planning. The first area involves the development of explicit and implicit dosimetry of PDT and light fluence rate calculation. The second area involves development of diode in-vivo dosimetry for point dose, EPID and Cherenkov imaging for real-time and planar dose of Radiation beams. The third area involves development of benchmark database for external beams (electron, photon, and proton) and image co-registrations. I have developed an integrated system for interstitial PDT light delivery and dosimetry for bulky tumors, including prostate and H&N cancers. A real-time treatment planning system is developed for intracavitory PDT utilizing an IR navigation system to track the real-time movement of the light source, including Pleural PDT. These techniques utilizes real-time feedback of light dosimetry to inform the 3D volumetric or 2D superficial light fluence calculations for PDT in heterogeneous environment. As a board certified Physicist in radiation oncology, I have been involved in the development of computational treatment planning system for external beams, medical imaging registration, radiation dose calculation, and patient motion monitoring.

Description of Clinical Expertise

Dr. Zhu is an ABR and ABMP board certified medical physicist. He is the associate director of PDT Physics, in charge of all PDT related physics aspect of PDT clinical protocols. His specialty includes external beam radiation therapy, IGRT/IMRT, PDT, small field dosimetry, MU calculations, TSE/TBI, in-vivo radiation dosimetry, and Machine QA.

Selected Publications

Michael J. LaRiviere, Timothy C. Zhu, John Christodouleas: Important technical considerations for implementing the ASTRO/ASCO/AUA prostate cancer hypofractionated radiation guideline. Prac. Rad Onc Page: in press, March 2019 Notes: doi: 10.1016/j.prro.2019.02.017.

Karl W. Beeson, Evgueni Parilov, Mary Potasek, Michele M. Kim, Timothy C. Zhu: Validation of combined Monte Carlo and photokinetic simulation of benzoporphyrin derivative-mediated photodynamic therapy on mice. J Biomed Opt 24(3): 035006, March 2019 Notes: doi:10.1117/1.JBO.24.3.035006.

Rice SR, Li YR, Busch TM, Kim MM, McNulty S, Dimofte A, Zhu TC, Cengel KA, Simone CB 2nd: A Novel Prospective Study Assessing the Combination of Photodynamic Therapy and Proton Radiation Therapy: Safety and Outcomes When Treating Malignant Pleural Mesothelioma. Photochem Photobiol 95(1): 411-418, Jan 2019 Notes: doi: 10.1111/php.13065.

Pogue BW, Zhu TC, Ntziachristos V, Paulsen KD, Wilson BC, Pfefer J, Nordstrom RJ, Litorja M, Wabnitz H, Chen Y, Gioux S, Tromberg BJ, Yodh AG: Fluorescence-Guided Surgery and Intervention - An AAPM Emerging Technology Blue Paper. Med Phys 45(6): 2681-2688, June 2018 Notes: doi: 10.1002/mp.12909.

George X. Ding, Parham Alaei, Bruce Curran, Ryan Thomas Flynn, Michael S. Gossman, Thomas R. Mackie, Moyed M. Miften, Richard L. Morin, X. George Xu, Timothy C. Zhu : Image Guidance Doses Delivered During Radiotherapy: Quantification, Management, and Reduction: Report of the AAPM Therapy Physics Committee Task Group 180. Med Phys 45(5): e84-e99, May 2018 Notes: doi:10.1002/mp.12824.

Peter H. Ahn, Jarod C Finlay, Shannon M Gallagher-Colombo, Harry Quon, Bert W. O'Malloy, Thomas Sollecito, Martin Greenberg, Charles B. Simone II, Sally McNulty, Alexander Lin, Timothy C. Zhu, Virginia Livolsi, Michael Feldman, Rosemarie Mick, Keith A. Cengel, Theresa M. Busch: Lesion Oxygenation Associates with Clinical Outcomes in Premalignant and Early Stage Head and Neck Tumors Treated on a Phase 1 Trial of Photodynamic Therapy. Photodiagnosis and Photodynamic Therapy 21: 28-35, Feb 2018 Notes: DOI:10.1016/j.pdpdt.2017.10.015.

Yihong Ong, Michele M Kim, Jarod C. Finlay, Andreea Dimofte, Sunil Singhal, Eli Glatstein, Keith Cengel, Timothy C Zhu (senor author): PDT dose dosimetry for photofrin-mediated pleural photodynamic therapy (pPDT). Phys Med Biol 63(1): 015031, Dec 2017 Notes: Doi:10.1088/1361-6560/aa9874.

Prabhu P. Mohapatra, Callistus O. Chiemezie, Arina Kligman, Michele M. Kim, Theresa M. Busch, Timothy C. Zhu and Alexander Greer: 31P NMR Evidence for Peroxide Intermediates in Lipid Emulsion Photooxidations: Phosphine Substituent Effects in Trapping. Photochem photobiol 93(6): 1430-1438, November/December 2017 Notes: DOI: 10.1111/php.12810.

Rozhin Penjweini, Michele M Kim, Timothy C. Zhu (senior author): Three-dimensional finite-element based deformable image registration for evaluation of pleural cavity irradiation during photodynamic therapy. Med Phys 44(7): 3767 - 3775, July 2017 Notes: DOI:10.1002/mp.12284.

Haixia Qiu, Michele M. Kim, Rozhin Penjweini, Jarod C. Finlay, Theresa M. Busch, Tianhao Wang, Wenshen Guo, Keith A. Cengel, Charles B. Simone II, Eli Glatstein, Timothy C. Zhu (senior author): A comparison of dose metrics to predict local tumor control for photofrin-mediated photodynamic therapy. Photochem. Photobiol. 93(4): 1115-1122, Jul 2017 Notes: DOI:10.1111/php.12719.

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Last updated: 03/16/2019
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