Department of Radiation Oncology

Timothy C. Zhu

faculty photo

Timothy C. Zhu, Ph.D.

Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology
Graduate Group Affiliations

Contact information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
University of Pennsylvania
3400 Civic Center Blvd, TRC W 4th floor
Philadelphia, PA 19104
Office: 215-662-4043
Fax: 215-615-5600
BS (Electric Engineering)
Fudan University, Shanghai, China , 1984.
M.Sc. (Physics)
Brown University , 1987.
M.Sc. (Engineering)
Brown University , 1988.
Ph.D. (Physics)
Brown University, 1991.
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Description of Research Expertise

My research focuses on PDT physics, in-vivo dosimetry, and external beam treatment planning. The first area involves the development of explicit and implicit dosimetry of PDT and light fluence rate calculation. The second area involves development of diode in-vivo dosimetry for point dose, EPID and Cherenkov imaging for real-time and planar dose of Radiation beams. The third area involves development of benchmark database for external beams (electron, photon, and proton) and image co-registrations. I have developed an integrated system for interstitial PDT light delivery and dosimetry for bulky tumors, including prostate and H&N cancers. A real-time treatment planning system is developed for intracavitory PDT utilizing an IR navigation system to track the real-time movement of the light source, including Pleural PDT. These techniques utilizes real-time feedback of light dosimetry to inform the 3D volumetric or 2D superficial light fluence calculations for PDT in heterogeneous environment. As a board certified Physicist in radiation oncology, I have been involved in the development of computational treatment planning system for external beams, medical imaging registration, radiation dose calculation, and patient motion monitoring.

Description of Clinical Expertise

Dr. Zhu is an ABR and ABMP board certified medical physicist. He is the associate director of PDT Physics, in charge of all PDT related physics aspect of PDT clinical protocols. His specialty includes external beam radiation therapy, IGRT/IMRT, PDT, small field dosimetry, MU calculations, TSE/TBI, in-vivo radiation dosimetry, and Machine QA.

Selected Publications

Indra J. Das, Poonam Yadav, Aaron D. Andersen, Zhe Jay Chen, Long Huang, Mark P. Lancer, Choonik Lee, Lin Li, Richard A. Popple, Roger K. Rice, Peter B. Schiff, Timothy C. Zhu, Mohamed E. Abazee: Dose Prescription and Reporting in Stereotactic Body Radiotherapy: A Multi-Institutional Study. Radiation Oncology 182: 109571, Feb 2023 Notes: doi: 10.1016/j.radonc.2023.109571.

Ryan D. Hall Morales, Yi Hong Ong, Jarod Finlay, Andreea Dimofte, Charles B. Simone, II, Joseph S. Friedberg, Theresa M. Busch, Keith A. Cengel, Timothy C. Zhu (senior author): In vivo spectroscopic evaluation of human tissue optical properties and hemodynamics during HPPH-mediated photodynamic therapy of pleural malignancies. J. Biomed Opt 27(10): 105006, October 2022 Notes: doi:10.1117/1.JBO.27.10.105006.

George X. Ding, Zhe J. Chen, Weili Zhong, Timothy C. Zhu: Skin dose distributions between Stanford and rotational techniques in total skin electron therapy (TSET). Med Phys 49(10): 6646-53, October 2022 Notes: doi:10.1002/mp.15907.

Karl Beeson, E Parilov, Mary Potasek, Timothy Zhu, Hongjing Sun, Dennis Sourvanos : Photodynamic therapy in a pleural cavity using monte carlo simulations with 2D/3D Graphical Visualization. Glob J Cancer Ther 8(1): 034, August 2022 Notes: doi:10.17352/2581-5407.000045.

Tianshun Miao, Rongxiao Zhang, Michael Jermyn, Petr Bruza, Timothy Zhu, Brian W. Pogue, David J.Gladstone, Benjamin B.Williamsab: Computational dose visualization & comparison in total skin electron treatment suggests superior coverage by the rotational versus the Stanford technique. J Med Imag Rad Sci Page: in press, Aug 28 2022 Notes: doi:10.1016/j.jmir.2022.08.006.

Hongjing Sun, Michele M Kim, Yi Hong Ong, Andreea Dimoft, Sunil Singhal, Theresa M. Busch, Keith A Cengel, and Timothy C Zhu (senior author): Evaluation Of Detector Position and Light Fluence Distribution Using an Infrared Navigation System during Pleural Photodynamic Therapy. Photochem photobiol Page: in press, published online 8/23/2022 2022 Notes: doi:10.1111/php.13697.

Timothy C. Zhu, Sotiris Stathakis, Jennifer R. Clark, Wenzheng Feng, Dietmar Georg, Shannon M. Holmes, Stephen F. Kry, Chang-Ming Charlie Ma, Moyed Miften, Dimitris Mihailidis, Jean M. Moran, Niko Papanikolaou, Bjorn Poppe, Ying Xiao: Report of AAPM Task Group 219 on independent calculation-based dose/MU verification for IMRT. Med Phys 48: e808-e829, July 2021 Notes: doi:10.1002/mp.15069.

Tianqi Sheng, Yihong Ong, Theresa M. Busch, Timothy C. Zhu (senior author): Reactive oxygen species explicit dosimetry to predict local tumor growth for Photofrin-mediated photodynamic therapy. Biomed Opt Exp 11(8): 4586-4601, Aug 2020 Notes: doi:10.1364/BOE.393524.

Yi Hong Ong, Joann Miller, Min Yuan, Malavika Chandra, Mirna El Khatib, Sergei A. Vinogradov, Mary E. Putt, Timothy C. Zhu, Keith A. Cengel, Arjun G. Yodh and Theresa M. Busch: Blood Flow Measurements Enable Optimization of Light Delivery for Personalized Photodynamic Therapy. Cancers 12(6): 1584, June 2020 Notes: doi:10.3390/cancers12061584.

T Miao, H Petroccia, Y Xie, M Jermyn, M Perroni-Scharf, N. Kapoor, J. M. Mahoney, T C Zhu, P Bruza, B. B. Williams, D. J. Goldstone, B. W. Pogue: Computer Animation Body Surface Analysis of Total Skin Electron Therapy Dose Homogeneity via Cherenkov Imaging. J Med Image 7(3): 034002, June 2020 Notes: doi:10.1117/1.JMI.7.3.034002.

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Last updated: 03/28/2023
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