Perelman School of Medicine at the University of Pennsylvania
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Jay Fitzgerald Dorsey

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Jay Fitzgerald Dorsey, M.D., Ph.D.

Assistant Professor of Radiation Oncology
Department: Radiation Oncology

Contact information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
TRC2W 3400 Civic Center Blvd
Philadelphia, PA 19104
Office: (215) 662-2428
Fax: (215) 349-5445
Education:
BSChE (Chemical Engineering)
University of Florida, 1995.
MSChE (Chemical Engineering)
University of South Florida, 1997.
Ph.D.
University of South Florida (H. Lee Moffitt Cancer Research Institute), 2003.
M.D.
University of South Florida College of Medicine, 2003.
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Description of Research Expertise

I conduct brain tumor research and specialize in treatment of patients with intracranial malignancies. I have scientific expertise in the areas of signal transduction, molecular therapeutics, brain tumor biology, and radiation biology. As a translational researcher, I am actively involved in basic mechanistic studies, the application of in vivo imaging methods to preclinical studies in relevant biological models of cancer, and early phase clinical trials in intracranial malignancies (as lead principal investigator). In a broad sense, my research focuses on understanding the underlying mechanisms whereby cancers demonstrate resistance to radiation and chemotherapy and characterizing normal cell/tissue responses to radiation therapy. This information will give us a framework to develop ways to target oncogenic pathways that lead to therapeutic resistance and identify potential molecular interventions that may reduce the normal tissue complications of radiation therapy. One major focus concerns the elucidation of the mechanism whereby ER stress modulates death receptor expression and initiation of apoptosis. A second area of interest is the application of in vivo imaging methods to preclinical studies in relevant biological models of cancer with a focus on high-grade brain tumor biology. This includes evaluation of the efficacy of novel therapeutic combinations in preclinical animal models and determination of timing, dosage, and in vivo mechanisms of anti-tumor action. In summary, I have a demonstrated record of successful and productive research projects in highly relevant areas of cancer, molecular oncology, and radiation biology.

Description of Clinical Expertise

I am a board-certified radiation oncologist who specializes in the treatment of cancers of the central nervous system with conventional radiation, IMRT, or stereotactic radiation. I am certified to perform gamma knife radiosurgery.

Selected Publications

Ju M, Kao G, Christodouleas J, Guzzo T, Keefe S, Hahn SM, Dorsey JF: Application of a Telomerase-based Circulating Tumor Cell (CTC) assay in bladder cancer patients receiving post-operative Radiation Therapy: A case study. CANCER BIOLOGY & THERAPY Mar 2014 Notes: Accepted for publication.

Yang W, Cooke M, Duckett C, Yang X, Dorsey JF: Distinctive effects of the cellular inhibitor of apoptosis protein c-IAP2 through stabilization by XIAP in glioblastoma multiforme cells. CELL CYCLE 13(6): 1-14, Mar 15 2014.

MacArthur KM, Kao GD, Chandrasekaran S, Alonso-Basanta M, Chapman C, Lustig RA, Wileyto EP, Hahn SM, Dorsey JF: Detection of brain tumor cells in the peripheral blood by a telomerase promoter-based assay CANCER RESEARCH Feb 13 2014 Notes: in press.

Ojerholm E, Lee JYK, Kolker J, Dorsey JF, Alonso-Basanta M: Gamma knife radiosurgery to 4 or more brain metastases in patients without prior intracranial radiation or surgery. CANCER MEDICINE Feb 10 2014.

Al Zaki A, Joh D, Cheng Z, de Barros AL, Kao G, Dorsey J, Tsourkas A: Gold-Loaded Polymeric Micelles for Computed Tomography-Guided Radiation Therapy Treatment and Radiosensitization. ACS NANO 8(1): 104-112, Dec 30 2013.

Joh DY, Kao GD, Murty S, Stangl M, Sun L, Al Zaki A, Xu X, Hahn SM, Tsourkas A, and Dorsey JF: Theranostic gold nanoparticles modified for durable systemic circulation effectively and safely enhance the radiation therapy of human sarcoma cells and tumors. TRANSLATIONAL ONCOLOGY 6(6): 722-731, Dec 1 2013.

Alonso-Basanta M, Fang P, Hahn SM, Lustig RA, Dorsey JF: A phase I study of nelfinavir concurrent with temozolomide and radiotherapy in patients with glioblastoma multiforme. JOURNAL OF NEUROONCOLOGY Nov 6 2013 Notes: Accepted for publication.

Dorsey JF, Sun L, Joh DY, Witztum A, Al Zaki A, Kao GD, Alonso-Basanta M, Avery S, Tsourkas A, Hahn SM: Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization. TRANSLATIONAL CANCER RESEARCH. Rao V. L. Papineni, Pataje G. Prasanna, Mansoor M. Ahmed (eds.). 2(4): 280-291, Aug 2013.

Chandrasekaran S, Hollander A, Xu X, Benci JL, Davis JJ, Dorsey JF, Kao G: (18)F-fluorothymidine-pet imaging of glioblastoma multiforme: effects of radiation therapy on radiotracer uptake and molecular biomarker patterns. THE SCIENTIFIC WORLD JOURNAL 2013, Apr 4 2013.

L. Sun, D. Joh, M. Stangl, A. Al-Zaki, S. Murty, M. Alonso-Basanta, G. Kao, J. Dorsey, A. Tsourkas: Selective Targeting of Brain Tumors With Nanoparticle-induced Radiosensitization and Contrast Enhancement. PRACTICAL RADIATION ONCOLOGY 3(2 Suppl 1): S19-20, Apr-Jun 2013.

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Last updated: 04/09/2014
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