Department of Radiation Oncology

Jay Fitzgerald Dorsey

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Jay Fitzgerald Dorsey, M.D., Ph.D.

Associate Professor of Radiation Oncology
Department: Radiation Oncology
Graduate Group Affiliations

Contact information
Department of Radiation Oncology
Perelman Center for Advanced Medicine
Bldg 421 SCTR 8-135
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: (215) 662-2428
Fax: (215) 349-5445
BSChE (Chemical Engineering)
University of Florida, 1995.
MSChE (Chemical Engineering)
University of South Florida, 1997.
University of South Florida College of Medicine, 2003.
University of South Florida (H. Lee Moffitt Cancer Research Institute), 2003.
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Description of Research Expertise

Jay Dorsey, MD, PhD has been continuously funded by the NIH for the past decade. He has expertise in genomics, precision medicine, circulating tumor material/liquid biopsy, molecular diagnostics, cancer biomarkers, nanoparticle therapeutics, preclinical tumor models, and clinical trials. His lab focuses on translational-facing research that explores areas of brain tumor biology, biomarkers of resistance/sensitivity to radiation and chemotherapies and identification of predictive/prognostic single-cell biomarkers of solid tumors, including GBM, lung and melanoma. He is Co-Leader of the Abramson Cancer Center's RadOnc Translational Center of Excellence.

Dr. Dorsey also serves as a standing member of the K99/R00 transition to independence NIH study section and is the PI and Director of the DEI-focused (NIH R25-funded undergraduate research pipeline program) SUPERS@PENN program which seeks to introduce the next generation of biomedical scientists to undergraduate research in oncology/medical physics/bioengineering/radiology/radiation biology.

He has published in journals such as Cancer Research, Cell, Nature Communications, Nature Cancer, ACS Nano, Int J Radiat Oncol Biol Phys., and Molecular Cancer Research.

His work has been funded by ASCO, RSNA, Burroughs Wellcome Fund, and the National Institutes of Health.

Description of Clinical Expertise

Jay Dorsey, MD, PhD is a University of Pennsylvania/Penn Medicine-trained Radiation Oncologist, physician, and scientist at the Perelman Center for Advanced Medicine and Smilow Center for Translational Research. He is a tenured Associate Professor at the University of Pennsylvania, where he has clinical expertise in treating primary and metastatic (lung, breast, skin, GI) tumors of the central nervous system. He is ABR board-certified in Radiation Oncology and trained and certified in Gamma Knife stereotactic precision radiosurgery.

His medical training and experience include an internship in Internal Medicine, ABR-sponsored Holman Research Pathway residency in Radiation Oncology at the Hospital of the University of Pennsylvania.

Selected Publications

Paul R, Dorsey JF, Fan Y: Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications. Pharmacol Ther. Mar 2022 Notes: PMID: 34480963 PMCID: PMC8844041 (available on 2023-03-01) DOI: 10.1016/j.pharmthera.2021.107985.

Lee SH, Kao GD, Feigenberg SJ, Dorsey JF, Frick MA, Jean-Baptiste S, Uche CZ, Cengel KA, Levin WP, Berman AT, Aggarwal C, Fan Y, Xiao Y: Multiblock Discriminant Analysis of Integrative 18F-FDG-PET/CT Radiomics for Predicting Circulating Tumor Cells in Early-Stage Non-small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 110(5): 1451-1465, Aug 2021 Notes: doi: 10.1016/j.ijrobp.2021.02.030. Epub 2021.

Mathilde Bouché, Yuxi C Dong, Saad Sheikh, Kimberly Taing, Deeksha Saxena, Jessica C Hsu, Minna H Chen, Ryan D Salinas, Hongjun Song, Jason A Burdick, Jay Dorsey, David P Cormode: Novel Treatment for Glioblastoma Delivered by a Radiation Responsive and Radiopaque Hydrogel. ACS Biomater Sci Eng. Jul 2021 Notes: PMID: 34160196 PMCID: PMC8411482 DOI: 10.1021/acsbiomaterials.1c00385.

Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey JF, Zou W, Nabavizadeh SA, Bagley SJ, Abdullah K, Brem S, Zhang L, Xu X, Byrne KT, Vonderheide RH, Gong Y, Fan Y.: Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nat Commun. 12(1), Jun 2021 Notes: doi: 10.1038/s41467-021-23832-3.

Jean-Baptiste SR, Feigenberg SJ, Dorsey JF, Kao GD: Personal and Prognostic: Tissue and Liquid Biomarkers of Radiotherapeutic Response in Non-Small Cell Lung Cancer. Semin Radiat Oncol. 31(2): 149-154, Apr 2021 Notes: doi:10.1016/j.semradonc.2020.11.002.

Teng CW, Amirshaghaghi A, Cho SS, Cai SS, De Ravin E, Singh Y, Miller J, Sheikh S, Delikatny E, Cheng Z, Busch TM, Dorsey JF, Singhal S, Tsourkas A, Lee JYK.: Combined fluorescence-guided surgery and photodynamic therapy for glioblastoma multiforme using cyanine and chlorin nanocluster. J Neurooncol. 2020 Sep 10. doi: 10.1007/s11060-020-03618-1. Online ahead of print. PMID: 32914293 2020.

Frick MA, Feigenberg SJ, Jean-Baptiste SR, Aguarin LA, Mendes A, Chinniah C, Swisher-McClure S, Berman A, Levin W, Cengel KA, Hahn SM, Dorsey JF, Simone CB 2nd, Kao GD.: Circulating Tumor Cells Are Associated with Recurrent Disease in Patients with Early-Stage Non-Small Cell Lung Cancer Treated with Stereotactic Body Radiotherapy. Clin Cancer Res. 2020 May 15;26(10):2372-2380. doi: 10.1158/1078-0432.CCR-19-2158. Epub 2020 Jan 22. PMID: 31969332 2020.

Jacob F, Salinas RD, Zhang DY, Nguyen PTT, Schnoll JG, Wong SZH, Thokala R, Sheikh S, Saxena D, Prokop S, Liu DA, Qian X, Petrov D, Lucas T, Chen HI, Dorsey JF, Christian KM, Binder ZA, Nasrallah M, Brem S, O'Rourke DM, Ming GL, Song H.: A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity. Cell. 2020 Jan 9;180(1):188-204.e22. doi: 10.1016/j.cell.2019.11.036. Epub 2019 Dec 26. PMID: 31883794 2020.

Cho SS, Sheikh S, Teng CW, Georges J, Yang AI, De Ravin E, Buch L, Li C, Singh Y, Appelt D, Delikatny EJ, Petersson EJ, Tsourkas A, Dorsey J, Singhal S, Lee JYK.: Evaluation of Diagnostic Accuracy Following the Coadministration of Delta-Aminolevulinic Acid and Second Window Indocyanine Green in Rodent and Human Glioblastomas. Mol Imaging Biol. 2020 Oct;22(5):1266-1279. doi: 10.1007/s11307-020-01504-w. PMID: 32514886 2020.

Baumann BC, Lustig RA, Mazzoni S, Grady SM, O'Malley BW, Lee JYK, Newman JG, Schuster JM, Both S, Lin A, Dorsey JF, Alonso-Basanta M: A prospective clinical trial of proton therapy for chordoma and chondrosarcoma: Feasibility assessment. J Surg Oncol. May 2019.

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Last updated: 09/12/2022
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