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Michael C. Phillips, Ph.D., D.Sc.

Adjunct Professor of Medicine
Department: Medicine

Contact information
CHOP
3615 Civic Center Blvd
Room 1102 ARC
4399
Philadelphia, PA 19104
Office: 215-590-0587
Fax: 215-590-0583
Education:
B.Sc. (Chemistry and Mathematics)
Southampton University, Southampton, England , 1962.
Ph.D. ( )
Southampton University, Southampton, England, 1965.
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Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention

CVI Research Description:
Elucidation of the molecular mechanisms underlying the anti-atherogenic properties of HDL and apolipoproteins A-I and E.

Selected Publications

Tanaka M, Koyama M, Dhanasekaran P, Nguyen D, Nickel M, Lund-Katz S, Saito H, Phillips MC: "Influence of Tertiary Structure Domain Properties on the functionality of Apolipoprotein A-I" Biochemistry 47: 2172-2180, 2008.

Duong PT, Weibel GL, Lund-Katz S, Rothblat GH, Phillips MC: "Characterization and Properties of Pre Beta-HDL Particles Formed by ABCA1-mediated Cellular Lipid Efflux to ApoA-I" J Lipid Res 49: 1006-1014, 2008.

Vedhachalam C, Duong PT, Nickel M, Nguyen D, Dhanasekaran P, Sait H, Rothblat GH, Lund-Katz S, Phillips MC: "Mechanism of ATP-binding Cassette Transporter AI (ABCA1)-mediated Cellular Lipid Efflux to Apolipoprotein A-I and Formation of High Density Lipoprotein Particles" J. Biol. Chem. 282: 25123-25130, 2007.

Vedhachalam C, Gehring AB, Davidson WS, Lund-Katz S, Rotyhblat GH, Phillips MC: "ABCA1-induced Cell Surface Binding Sites for ApoA-I" Arterioscler Thromb Vasc Biol. 27: 1603-1609, 2007.

Duong PT, Collins HL, Nickel M, Lund-Katz S, Rothblat GH, Phillips MC: "Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I" J Lipid Res 47: 832-843, 2006.

Vedhachalam C, Liu L, Nickel M, Dhanasekaran P, Anantharamaiah GM, Lund-Katz S, Rothblat GH, Phillips MC: "Influence of ApoA-I structure on the ABCA1-mediated efflux of cellular lipids" J Biol Chem 279: 49931-49939, 2004.

Saito H, Dhanasekaran P, Nguyen D, Deridder E, Holvoet P, Lund-Katz S, Phillips MC: "Alpha-helix formation is required for high affinity binding of human apolipoprotein A-I to lipids" J Biol Chem 279: 20974-20981, 2004.

Thuahnai ST, Lund-Katz S, Dhanasekaran P, de la Llera-Moya M, Connelly MA, Williams DL, Rothblat GH, Phillips MC: "Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure" J Biol Chem 13: 12448-12455, 2004.

Saito H, Dhanasekaran P, Nguyen D, Holvoet P, Lund-Katz S, Phillips MC: "Domain structure and lipid interaction in human apolipoproteins A-I and E, a general model" J Biol Chem 278: 23227-23232, 2003.

Jonas A, Phillips MC: "Lipoprotein Structure" Biochemistry of Lipids, Lipoproteins and Membranes. D.E. Vance and J.E. Vance (eds.). Elsevier, Page: 485-506, 2008.

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Last updated: 10/15/2012
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