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Toshinori Hoshi, PhD

Professor of Physiology
Department: Physiology
Graduate Group Affiliations

Contact information
605 CRB
415 Curie Blvd
Department of Physiology
Philadelphia, PA 19104
Office: 215-573-7305
B.A. (Psychology)
University of New Hampshire, 1981.
Ph.D. (Physiology)
Yale University, 1985.
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> Perelman School of Medicine   > Faculty   > Details

Description of CVI Expertise

CVI Program Unit(s):
Channel Biology / Electrophysiology

CVI Research Description:
My research interests cover regulation of ion channels, in particular, large-conductance calcium-dependent potassium channels, by oxidation and heme/heme catabolic byproducts and lipid messengers such as PIP2 and omega-3 fatty acids. Our goals is to describe the modulatory phenomena in detail and relate the biophysical and molecular changes to address integrative physiology issues.

Selected Publications

Hoshi, T., Wissuwa, B., Tian, Y., Tajima, N., Xu, R., Bauer, M., Heinemann, S. H., Hou, S: Omega-3 Fatty Acids Lower Blood Pressure by Directly Activating Large-Conductance Ca2+-Dependent K+ Channels. Proc Natl Acad Sci U S A 110: 4816-4821, 2013.

Hoshi, T., Xu, R., Hou, S., Heinemann, S. H., Tian, Y: A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid. J Gen Physiol 142: 507-522, 2013.

Hoshi, T., Tian, Y., Xu, R., Heinemann, S. H., Hou, S: Mechanism of the Modulation of BK Potassium Channel Complexes with Different Auxiliary Subunit Compositions by the Omega-3 Fatty Acid DHA. Proc Natl Acad Sci U S A 110: 4822-1877, 2013.

Hoshi T, Pantazis A, Olcese R.: Transduction of voltage and Ca2+ signals by Slo1 BK channels. Physiology (Bethesda) 28: 172-189, 2013.

Hoshi T, Armstrong CM.: C-type inactivation of voltage-gated K+ channels: pore constriction or dilation? J Gen Physiol. 141: 151-160, 2013.

Sahoo, N., Goradia, N., Ohlenschlager, O., Schonherr, R., Friedrich, M., Plass, W., Kappl, R., Hoshi, T., Heinemann, S. H.: Heme impairs the ball-and-chain inactivation of potassium channels. Proc Natl Acad Sci U S A 110: E4036-4044, 2013.

Sahoo, N., Hoshi, T., Heinemann, S. H: Oxidative modulation of voltage-gated potassium channels. Antioxidants & redox signaling 2013/09/18 2013.

Banerjee A, Trivedi CM, Damera G, Jiang M, Jester W, Hoshi T, Epstein JA, Panettieri RA, Jr. : Trichostatin A abrogates airway constriction, but not inflammation, in murine and human asthma models. Am J Respir Cell Mol Biol. 46: 132-138, 2012.

Damera G, Druey KM, Cooper PR, Krymskaya VP, Soberman RJ, Amrani Y, Hoshi T, Brightling CE, Panettieri RA, Jr.: An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma. PLoS One 7: e28504, 2012.

Hoshi T, Armstrong CM. : Initial steps in the opening of a Shaker potassium channel. Proc Natl Acad Sci U S A. 109, 2012.

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Last updated: 05/07/2014
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