Peter Francis Davies, B.Sc. M.Sc. M.A. Ph.D.
Robinette Foundation Professor of Cardiovascular Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
1010 Vagelos Research Lab
3340 Smith Walk
Philadelphia, PA 19104-6383
3340 Smith Walk
Philadelphia, PA 19104-6383
Office: (215) 573-6813
Fax: (215) 573-6815
Fax: (215) 573-6815
Email:
pfd@pobox.upenn.edu
pfd@pobox.upenn.edu
Publications
Links
Search PubMed for articles
Pharmacological Sciences graduate group faculty
Cell and Molecular Biology graduate group faculty
Institute for Medicine and Engineering research
Search PubMed for articles
Pharmacological Sciences graduate group faculty
Cell and Molecular Biology graduate group faculty
Institute for Medicine and Engineering research
Education:
BSc. (Chemistry/Biochemistry (w/Hons.))
University of Newcastle-upon-Tyne, UK, 1969.
MSc. (Biochemistry)
University of Victoria, B.C., Canada, 1972.
Ph.D. (Experimental Pathology)
Cambridge University, UK, 1975.
Permanent linkBSc. (Chemistry/Biochemistry (w/Hons.))
University of Newcastle-upon-Tyne, UK, 1969.
MSc. (Biochemistry)
University of Victoria, B.C., Canada, 1972.
Ph.D. (Experimental Pathology)
Cambridge University, UK, 1975.
Description of CVI Expertise
CVI Program Unit Administrator:Biotechnology / Nanomedicine / Imaging
Research Interests
Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Vascular Cell Communication, Cytoskeletal and membrane biophysics.
Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, endothelial genomics.
Description of Research
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics andcomputational fluid dynamics.
Rotation Projects for 2003-2004
Please discuss with Dr. Davies.
Lab Personnel:
Tony Passerini PhD, Postdoctoral Fellow
David Kaufman MD, Postdoctoral Fellow
Craig Simmons PhD, Postdoctoral Fellow
Jon Lakins PhD, Postdoctoral Fellow
Jenny Zilberberg PhD, Postdoctoral Fellow
Richard Magid PhD, Postdoctoral Fellow
Mete Civelek, Graduate Student
Yun Fang, Graduate Student
Technical Staff: Congzhu Shi PhD, Technical Staff
Nadeene Francesco, Technical Staff
Rebecca Riley, Technical Staff
Richard Kim, Student Intern
Gary Chang, Student Intern
Tran Lo, Student Intern
Justyna Mach, Student Intern
Matthew Henry, Student Intern
Selected Publications
Davies PF, Civelek M, Fang Y, Guerraty MA, Passerini AG: Endothelial phenotype heterogeneity in regions of altered flow dynamics in vivo. Seminars in Thrombosis and Hemostasis Page: In Press, 2010 Notes: Special Issue: Under-recognized Significance of Endothelial Heterogeneity.Jimenez JM, Davies PF. : Design implications for endovascular stents and the endothelium. Hemodynamics & Mechanobiology of Endothelium Hsiai J, Blackman B, Jo H. (eds.). World Scientific Press, Page: In Press, 2010.
Waters SL, Alastruey J, Beard DA, Bovendeerd PH, Davies PF, Jayaraman G, Jensen OE, Lee J, Parker KH, Popel AS, Secomb TW, Sherwin, SJ, Shipley RJ, Smith NP, van de Vosse FN: Coronary Vascular Biomechanics. Progress in Biophysics and Molecular Biology Page: In Press, 2010.
Civelek, M., Manduchi, E., Riley, R., Stoeckert, C.J., Davies, P.F.: Chronic endoplasmic reticulum (ER)-stress partially activates unfolded protein response (UPR) in arterial endothelium in regions susceptible to atherosclerosis. Circulation Research 105: 453-461, October 2009.
Jimenez, JM and Davies, PF: Hemodynamically-driven stent strut design. Annals Biomedical Engineering 37: 1483-1495, August 2009.
Helmke BP and Davies PF: Imaging Live Cells under Mechanical Stress. In: Live Cell Imaging: A Laboratory Manual, 2nd Edition. Spector DL and Goldman RL (eds.). Cold Spring Harbor Laboratory Press, Page: In Press, 2009.
Karamanian, A., Jimenez, J.M., Davies, P.F. : Differential arterial site-specific expression of endothelial Claudin-5 maps to atherosusceptibility, is disturbed flow-sensitive, and regulates permeability. Circulation Research In Review, 2009.
Davies, P.F., Helmke, B.P: Endothelial Mechanotransduction. In: ‘Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissue’ Mofrad, R.K. and Kamm, R.D. (eds.). Cambridge University Press, Page: 20-40, 2009.
PF Davies: Shear Stress and the Endothelium in Cardiovascular Pathophysiology. Nature Clinical Practice Cardiovascular Medicine (now: Nature Reviews Cardiology) 6: 16-26, 2009.
Civelek, M., Grant, GR, Irolla, CR, Shi C, Riley R, Chiesa O, Stoeckert CJ, Karanian JW, Pritchard WF, Davies PF. : Pre-lesional arterial endothelial responses in hypercholesterolemia: Universal ATP-Binding Cassette A1 (ABCA1) upregulation contrasts with region-specific gene expression in vivo. Am. J. Physiology (Heart and Circulatory) In press, 2009.
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