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Peter F. Davies, Ph.D., Sc.D.

Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
1010 Vagelos Research Lab
3340 Smith Walk
Philadelphia, PA 19104-6383
Office: (215) 573-6813
Fax: (215) 573-6815
B.Sc. (Chemistry/Ag. Biochemistry (w/Hons.))
University of Newcastle-upon-Tyne, 1969.
M.Sc. (Biochemistry)
University of Victoria, B.C., Canada, 1972.
Ph.D. (Experimental Pathology)
University of Cambridge, 1975.
Sc.D. (Higher Doctorate)
University of Cambridge, 2015.
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> Perelman School of Medicine   > Faculty   > Details

Description of CVI Expertise

Research Interests
Cell and molecular biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Vascular Cell Communication, Cytoskeletal and membrane biophysics. Genomics and epigenomics of the endothelium.

Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, endothelial genomics.

Description of Research
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Experimental approaches ranging from cell and molecular phenotyping, membrane biophysics, to biomechanics, computational fluid dynamics, genomics, epigenomics, 4-D flow MRI and endocardial endothelial phenotypes.

Selected Publications

Davies P.F.: In: LabStudio: Design Research Between Architecture & Biology. Routledge / Taylor and Francis Sabin J and Jones P. (eds.). Routledge / Taylor and Francis, Nov 2017.

Davies PF, Manduchi E, Stoeckert CJ, Jiménez JM, Jiang Y-Z: Biofluids, Cell Mechanics and Epigenetics: Flow-induced Epigenetic Mechanisms of endothelial gene expression. Journal of Biomechanics 50: 3-10, January 2017.

McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF.: Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress. Journal of Biomechanics 50: 11-19, January 2017.

Davies PF, Manduchi E, Stoeckert CJ, Jiang YZ: Endothelial epigenetics and its role in mediating biomechanical stress of hypertension. J. Hypertension 34; Suppl 1-ISH 2016: e371, September 2016.

McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF.: Integrated regional cardiac hemodynamic imaging and RNA sequencing reveals corresponding heterogeneity of ventricular wall shear stress and the endocardial transcriptome. J Am Heart Assoc 18;5(4). pii: e003170.: doi: 10.1161/JAHA.115.003170, April 2016.

Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML.: Lymph flow regulates collecting lymphatic vessel maturation in vivo. J. Clin Invest. 125: 2995-3007, August 2015.

Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR. : Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Controlled Release 210: 39-47, July 2015.

Jiang, Y-Z, Manduchi, E, Stoeckert CJ, Davies PF.: Arterial endothelial methylome: Differential DNA methylation in athero-susceptible disturbed flow regions in vivo. BMC Genomics 16: 506, July 2015.

Chacko A-M, Han J, Zern BJ, Greineder C, Mikitsch JL, Nayak M, Menon D, Poncz M, Johnston I, Eckman D, Davies PF, Muzykantov VR. : Collaborative enhancement of endothelial nanocarrier targeting by modulating PECAM-1/CD31 epitope engagement. Am. Chem. Soc. Nano. 9(7): 6785-6793, July 2015.

Jiang Y-Z, Manduchi E, Jimenez JM, Davies PF. : Endothelial epigenetics in biomechanical stress: Disturbed flow-mediated epigenomic plasticity in vivo and in vitro. Arterioscler Thromb Vasc Biol 35: 1317-1326, June 2015.

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Last updated: 11/17/2017
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