Peter F. Davies
Robinette Foundation Professor of Cardiovascular Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
1010 Vagelos Research Lab
3340 Smith Walk
Philadelphia, PA 19104-6383
3340 Smith Walk
Philadelphia, PA 19104-6383
Office: (215) 573-6813
Fax: (215) 573-6815
Fax: (215) 573-6815
Email:
pfd@pobox.upenn.edu
pfd@pobox.upenn.edu
Publications
Links
Search PubMed for articles
Cell and Molecular Biology graduate group faculty
Pharmacological Sciences graduate group faculty
Institute for Medicine and Engineering research
Search PubMed for articles
Cell and Molecular Biology graduate group faculty
Pharmacological Sciences graduate group faculty
Institute for Medicine and Engineering research
Education
BSc. (Chemistry/Biochemistry (w/Hons.))
University of Newcastle-upon-Tyne, UK, 1969.
MSc. (Biochemistry)
University of Victoria, B.C., Canada, 1972.
Ph.D. (Experimental Pathology)
Cambridge University, UK, 1975.
Permanent linkBSc. (Chemistry/Biochemistry (w/Hons.))
University of Newcastle-upon-Tyne, UK, 1969.
MSc. (Biochemistry)
University of Victoria, B.C., Canada, 1972.
Ph.D. (Experimental Pathology)
Cambridge University, UK, 1975.
Description of CVI Expertise
CVI Program Unit Administrator:Biotechnology / Nanomedicine / Imaging
Research Interests
Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Vascular Cell Communication, Cytoskeletal and membrane biophysics.
Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, endothelial genomics.
Description of Research
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics andcomputational fluid dynamics.
Rotation Projects for 2003-2004
Please discuss with Dr. Davies.
Lab Personnel:
Tony Passerini PhD, Postdoctoral Fellow
David Kaufman MD, Postdoctoral Fellow
Craig Simmons PhD, Postdoctoral Fellow
Jon Lakins PhD, Postdoctoral Fellow
Jenny Zilberberg PhD, Postdoctoral Fellow
Richard Magid PhD, Postdoctoral Fellow
Mete Civelek, Graduate Student
Yun Fang, Graduate Student
Technical Staff: Congzhu Shi PhD, Technical Staff
Nadeene Francesco, Technical Staff
Rebecca Riley, Technical Staff
Richard Kim, Student Intern
Gary Chang, Student Intern
Tran Lo, Student Intern
Justyna Mach, Student Intern
Matthew Henry, Student Intern
Selected Publications
Davies P.F.: Hemodynamics in the determination of the endothelial phenotype and flow mechanotransduction. In: ‘Endothelial Biomedicine; A Comprehensive Treatise’, Aird,.W.C. (eds.). Cambridge University Press. Page: 230-245, 2007.DeLisser, H.M., Helmke, B.P., Cao, G., Pooler, P.M., Taichman, D., Fehrenbach, M., Zaman, A., Cui, Z., Mohan, G.S., Baldwin, H.S., Davies, P.F., Savani, R.C: Loss of PECAM-1 function impairs lung alveolization. J. Biol. Chem. 281: 8724-31, 2006.
Davies, P.F., Spaan, J.A., Krams, R. : Shear Stress Biology of the Endothelium. Annals Biomed. Engineering 18: 54-59, 2005.
Passerini, A., Shi, C.,. Francesco, N.M., Chuan, P., Manduchi, E., Grant, G., Stoeckert, C.J., Pritchard, W.P., Karanian, J.W., and Davies, P.F. : Regional determinants of arterial endothelial phenotype dominate the impact of gender or short-term exposure to a high-fat diet. Biochem. Biophys. Research Communications 332: 142-148, 2005.
Fang, Y., Romanenko, V., Shi, C., Schram, G., Nattel, S., Davies, P.F., Levitan, I: Functional expression of Kir2.x in human aortic endothelial cells: dominant role of Kir2.2. Am. J. Physiol. 289: C1134-1144, Nov 2005.
Simmons, C.A, Manduchi, E., Grant, G., Davies, P.F.: Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves Circ. Research 96: 792-799, 2005.
Magid, R., Davies, P.F. : Endothelial protein kinase C isoform identity and differential activity of PKCζ in an athero-susceptible region of porcine aorta. Circulation Research 97: 443-449, 2005.
Passerini, A., Polacek, D.C., Shi, C.,. Francesco, N.M., Manduchi, E., Grant, G., Pritchard, W.P., Powell, S.J., Chang, G., Stoeckert, C., Davies, P.F. : Coexisting pro-inflammatory and anti-oxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta. Proc. Natl. Acad. Sci. USA 101: 2482-2497, February 2004.
Davies P.F.: Blood Capsule: Hemodynamics shifts eNOS in vivo. Blood In Press, 2005.
Helmke, B.P. Rosen, A.B., Davies, P.F.: Mapping Mechanical Strain of an Endogenous Cytoskeletal Network in Living Endothelial Cells. Biophys. J. 84: 2691-2699, 2003.
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