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Frank E. Silvestry, M.D.

Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Cardiovascular Division
Department of Medicine
11-133 South Pavillion PCAM
3400 Civic Center Boulevard
Hospital of the University of Pennsylvania
Philadelphia, PA 19104
Office: 215 615 5236
Fax: 215 349 8190
B.S. (Biochemistry)
State University of New York at Binghamton, 1986.
M.D. (Medicine)
University of Pennsylvania, 1990.
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Description of CVI Expertise

Associate Chief for Education, Cardiovascular Division
Director, Penn Cardiovascular Fellowship Program

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention
Biotechnology / Nanomedicine / Imaging

CVI Research Description:
Research interests include application of novel imaging techniques including guidance of percutaneous noncoronary interventions, 3D imaging, and ultrasound enabled catheters. Additional interests include noninasive detection of atherosclerosis including imaging and biomarkers, novel preventative therapies, and effect of diets on cardiovascular health.

Selected Publications

Kaye David M, Hasenfuß Gerd, Neuzil Petr, Post Martijn C, Doughty Robert, Trochu Jean-Noël, Kolodziej Adam, Westenfeld Ralf, Penicka Martin, Rosenberg Mark, Walton Antony, Muller David, Walters Darren, Hausleiter Jorg, Raake Philip, Petrie Mark C, Bergmann Martin, Jondeau Guillaume, Feldman Ted, Veldhuisen Dirk J van, Ponikowski Piotr, Silvestry Frank E, Burkhoff Dan, Hayward Christopher: One-Year Outcomes After Transcatheter Insertion of an Interatrial Shunt Device for the Management of Heart Failure With Preserved Ejection Fraction. Circulation. Heart failure 9(12), Dec 2016.

Rene AG, Jagasia D, Wickramasinghe SR, Desai N, Szeto W, Vallabhajosyula P, Li RH, Silvestry FE, Giri J, Jha S, Herrmann HC, Anwaruddin S1: New Ventricular Septal Defects Following Balloon-Expandable Transcatheter Aortic Valve Replacement. J Invasive Cardiol 28(7): E59-65, July 2016.

Feldman Ted, Komtebedde Jan, Burkhoff Daniel, Massaro Joseph, Maurer Mathew S, Leon Martin B, Kaye David, Silvestry Frank E, Cleland John G F, Kitzman Dalane, Kubo Spencer H, Van Veldhuisen Dirk J, Kleber Franz, Trochu Jean-Noël, Auricchio Angelo, Gustafsson Finn, Hasenfuβ Gerd, Ponikowski Piotr, Filippatos Gerasimos, Mauri Laura, Shah Sanjiv J: Transcatheter Interatrial Shunt Device for the Treatment of Heart Failure: Rationale and Design of the Randomized Trial to REDUCE Elevated Left Atrial Pressure in Heart Failure (REDUCE LAP-HF I). Circulation. Heart failure 9(7), Jul 2016.

Liang JJ, Silvestry FE.: Mechanistic insights into mitral regurgitation due to atrial fibrillation: "atrial functional mitral regurgitation" Trends Cardiovasc Med May 2016.

Hasenfuß Gerd, Hayward Chris, Burkhoff Dan, Silvestry Frank E, McKenzie Scott, Gustafsson Finn, Malek Filip, Van der Heyden Jan, Lang Irene, Petrie Mark C, Cleland John G F, Leon Martin, Kaye David M: A transcatheter intracardiac shunt device for heart failure with preserved ejection fraction (REDUCE LAP-HF): a multicentre, open-label, single-arm, phase 1 trial. Lancet (London, England) 387(10025): 1298-304, Mar 2016.

Feldman Ted, Kar Saibal, Elmariah Sammy, Smart Steven C, Trento Alfredo, Siegel Robert J, Apruzzese Patricia, Fail Peter, Rinaldi Michael J, Smalling Richard W, Hermiller James B, Heimansohn David, Gray William A, Grayburn Paul A, Mack Michael J, Lim D Scott, Ailawadi Gorav, Herrmann Howard C, Acker Michael A, Silvestry Frank E, Foster Elyse, Wang Andrew, Glower Donald D, Mauri Laura: Randomized Comparison of Percutaneous Repair and Surgery for Mitral Regurgitation: 5-Year Results of EVEREST II. Journal of the American College of Cardiology 66(25): 2844-54, Dec 2015.

Frank E. Silvestry, MD: Primary Mitral Valve Regurgitation Treatment Options. American College of Cardiology/ November 2015.

Frank E. Silvestry, MD, FASE, Chair, Meryl S. Cohen, MD, FASE, Co-Chair, Laurie B. Armsby, MD, FSCAI, Nitin J. Burkule, MD, DM, FASE, Craig E. Fleishman, MD, FASE, Ziyad M. Hijazi, MD, MPH, MSCAI, Roberto M. Lang, MD, FASE, Jonathan J. Rome, MD, and Yan Wang, RDCS : Guidelines for the Echocardiographic Assessment of Atrial Septal Defect and Patent Foramen Ovale: From the American Society of Echocardiography and Society for Cardiac Angiography and Interventions J Am Soc Echocardiogr 28: 910-58, August 2015.

Kiss D, Lilly SM, Silvestry F: Coronary sinus atrial communication in a 58 year old. Eur Heart J Cardiovasc Imaging 15(10): 1100, Oct 2014.

Silvestry FE, Kadakia MB, Willhide J, Herrmann HC: Initial experience with a novel real-time three-dimensional intracardiac ultrasound system to guide percutaneous cardiac structural interventions: a phase 1 feasibility study of volume intracardiac echocardiography in the assessment of patients with structural heart disease undergoing percutaneous transcatheter therapy. J Am Soc Echocardiogr 27(9): 978-83, Sep 2014.

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Last updated: 09/12/2017
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