Frank E. Silvestry, MD
Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
Attending Physician, Hospital of the University of Pennsylvania
Program Director, Cardiovascular Disease Fellowship Program, Hospital of the University of Pennsylvania
Associate Chief for Education, Cardiovascular Division, Perelman School of Medicine
Department: Medicine
Contact information
Division of Cardiovascular Medicine
11-133 South Pavilion PCAM
3400 Civic Center Boulevard
Hospital of the University of Pennsylvania
Philadelphia, PA 19104
11-133 South Pavilion PCAM
3400 Civic Center Boulevard
Hospital of the University of Pennsylvania
Philadelphia, PA 19104
Office: 2156208142
Fax: 215 349 8190
Fax: 215 349 8190
Publications
Education
B.S. (Biochemistry)
State University of New York at Binghamton, 1986.
M.D. (Medicine)
University of Pennsylvania, 1990.
Permanent linkB.S. (Biochemistry)
State University of New York at Binghamton, 1986.
M.D. (Medicine)
University of Pennsylvania, 1990.
Description of Research Expertise
Mitral Valve DiseasePatent Foramen Ovale
Atrial Septal Defect
Structural heart disease
Valvular heart disease
Cardiac Imaging
Intracardiac Echocardiography
Interventional Echocardiography
Description of Clinical Expertise
Mitral Valve DiseasePatent Foramen Ovale
Atrial Septal Defect
Intracardiac Echocardiography
Interventional Echocardiography
Valvular heart disease
Preventitive cardiology
Lipid abnormalities
Metabolic syndrome
Selected Publications
Sannino A, Grayburn PA, Kodali SK, Lurz P, Thourani VH, Makar M, Haeffele C, Puthumana J, Lee J, Flueckiger P, Chadderdon S, Padang R, Sekaran NK, Stewart-Dehner T, Ender J, Koulogiannis K, Morsy M, Miyasaka R, Havens B, Ku I, Silvestry F, Näbauer M, Gleason P, Lindman BR, Ho E, Good M, Gößler T, Cohen JA, Harris A, Sengupta P, Kelly N, Maksoud A, Weber M, Romero S, Yucel E, Raghunathan D, Skolnick D, Wang L, Sun YP, Vainrib A, Kapila A, Mackensen GB, Aman E, Mehrkens D, Ivannikova M, Smith W, Abramson S, Treat S, Toufan M, Mack MJ, Leon MB, Hahn RT; TRISCEND II Pivotal Trial Investigators.: TRISCEND II: Effect of Transcatheter Tricuspid Valve Replacement on Echocardiographic Measures of Right Heart Remodeling and Function. JACC Cardiovasc Imaging Jul 2026.Doi S, Kazui S, Akashi N, Patel RB, Komtebedde J, Mylavarapu U, Swarup V, Winkler S, Backhaus SJ, Litwin SE, Mohan RC, Kawash R, Sverdlov AL, Chung ES, Kaye DM, Hoendermis E, Hummel SL, Cikes M, Hayward CS, Starling R, Gupta DK, Zirlik A, McKenzie S, Nair A, Rieth A, Cutlip DE, Solomon SD, van Veldhuisen DJ, Leon MB, Silvestry FE, Shah SJ, Borlaug BA.: Heart Failure Duration, Cardiac Remodeling, Dysfunction, and Hemodynamic Severity in HFpEF and HFmrEF: Insights From REDUCE LAP-HF II. JACC Heart Fail Jun 2026.
Sannino A, Ilardi F, Hahn RT, Toufan M, Nickolite K, Agarwal V, Havens B, Ku I, Silvestry F, Weckbach L, Gleason P, Pretorius M, Ho E, Tulloch J, Ruf T, Cohen J, Duggal N, Sengupta PP, Kelly N, Chehab BM, Vogelhuber J, Vad S, Deuschl F, Thourani VH, Lurz P, Kodali SK, Grayburn PA.: Echocardiographic Imaging Considerations for Post-Implant Evaluation of the Transcatheter EVOQUE Tricuspid Valve Replacement System. JACC Cardiovasc Imaging Jul 2025.
Hahn RT, Makkar R, Thourani VH, Makar M, Sharma RP, Haeffele C, Davidson CJ, Narang A, O'Neill B, Lee J, Yadav P, Zahr F, Chadderdon S, Eleid M, Pislaru S, Smith R, Szerlip M, Whisenant B, Sekaran NK, Garcia S, Stewart-Dehner T, Thiele H, Kipperman R, Koulogiannis K, Lim DS, Fowler D, Kapadia S, Harb SC, Grayburn PA, Sannino A, Mack MJ, Leon MB, Lurz P, Kodali SK; TRISCEND II Trial Investigators.: Transcatheter Valve Replacement in Severe Tricuspid Regurgitation. N Engl J Med 392: 115-126, Jan 2025.
Writing Committee Members:; ACC Competency Management Committee:.: 2025 ACC/AHA/ASE/ASNC/SCCT/SCMR advanced training statement on advanced cardiovascular imaging: A Report of the ACC Competency Management Committee. J Nucl Cardiol 2025.
Baldassarre LA, Mendes LA, Blankstein R, Hahn RT, Patel AR, Russell R, Abbara S, Ahmad SM, Brady MB, Bullock-Palmer RP, Cavalcante JL, Chareonthaitawee P, Chen T, Clark DE, Conaway DG, Daubert MA, Day J, Di Carli MF, Galazka P, Gallegos-Kattán C, Herrmann H, Ho EC, Jellis CL, Le VT, Lema PC, Litmanovich DE, Little SH, Liu JE, Lopez-Mattei JC, Lumsden AB, Malaisrie SC, Melduni RM, Nieman K, Nikravan S, Ordovas KG, Parwani P, Patel KK, Phoubandith DR, Punnoose LR, Rybicki FJ, Sensakovic WF, Shapiro MD, Sperry BW, Spragg D, Tong MS, Vogel-Bass E, Volgman AS, Waheed A, Weissman G, Wells BJ, Weissman G, Ashwath ML, Breinholt JP 3rd, Clark DE, Damp JB, Day J, Denktas A, Drajpuch D, Faza N, Frank L, Goldman ME, Hahn RT, Housholder-Hughes SD, Joglar JA, Kondapaneni MD, Le VT, Lee KS, Lin CH, Mahar JH, Mendes LA, Nfor TK, Niazi K, Parker AM, Patil P, Pearson DD, Pfeiffer M, Punnoose LR, Reejhsinghani RS, Silvestry FE, Singh HS, Solomon M, Smer AM, Vallabhajosyula S, Vorchheimer DA, Werns SW, Westwood M.: 2025 ACC/AHA/ASE/ASNC/SCCT/SCMR Advanced Training Statement on Advanced Cardiovascular Imaging: A Report of the ACC Competency Management Committee. J Cardiovasc Comput Tomogr 2025.
Petzl AM, Peters CJ, Frankel DS, Silvestry FE, Shivamurthy P.: Electrical instability and sudden loss of pacemaker capture-A tale of flecainide toxicity. HeartRhythm Case Rep. 11(1): 66-69, October 2024.
Patel RB, Silvestry FE, Komtebedde J, Solomon SD, Hasenfuß G, Litwin SE, Borlaug BA, Price MJ, Kawash R, Hummel SL, Cutlip DE, Leon MB, van Veldhuisen DJ, Rieth AJ, McKenzie S, Bugger H, Mazurek JA, Kapadia SR, Vanderheyden M, Ky B, Shah SJ.: Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction: The REDUCE LAP-HF II Randomized Clinical Trial. JAMA Cardiol Apr 2024.
Kodali S, Hahn RT, Makkar R, Makar M, Davidson CJ, Puthumana JJ, Zahr F, Chadderdon S, Fam N, Ong G, Yadav P, Thourani V, Vannan MA, O'Neill WW, Wang DD, Tchétché D, Dumonteil N, Bonfils L, Lepage L, Smith R, Grayburn PA, Sharma RP, Haeffele C, Babaliaros V, Gleason PT, Elmariah S, Inglessis-Azuaje I, Passeri J, Herrmann HC, Silvestry FE, Lim S, Fowler D, Webb JG, Moss R, Modine T, Lafitte S, Latib A, Ho E, Goldberg Y, Shah P, Nyman C, Rodés-Cabau J, Bédard E, Brugger N, Sannino A, Mack MJ, Leon MB, Windecker S.: Transfemoral tricuspid valve replacement and one-year outcomes: the TRISCEND study. Eur Heart J 44: 4862-4873, Dec 2023.
Schaller RD, Vigdor A, Silvestry FE: Inadvertent left atrial injury during transseptal puncture with a radiofrequency-powered wire. J Interv Card Electrophysiol 66(7): 1561-1562, Oct 2023.