Frank E. Silvestry, MD
Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
Attending Physician, Hospital of the University of Pennsylvania
Program Director, Cardiovascular Disease Fellowship Program, Hospital of the University of Pennsylvania
Associate Chief for Education, Cardiovascular Division, Perelman School of Medicine
Department: Medicine
Contact information
Division of Cardiovascular Medicine
11-133 South Pavilion PCAM
3400 Civic Center Boulevard
Hospital of the University of Pennsylvania
Philadelphia, PA 19104
11-133 South Pavilion PCAM
3400 Civic Center Boulevard
Hospital of the University of Pennsylvania
Philadelphia, PA 19104
Office: 2156208142
Fax: 215 349 8190
Fax: 215 349 8190
Publications
Education:
B.S. (Biochemistry)
State University of New York at Binghamton, 1986.
M.D. (Medicine)
University of Pennsylvania, 1990.
Permanent linkB.S. (Biochemistry)
State University of New York at Binghamton, 1986.
M.D. (Medicine)
University of Pennsylvania, 1990.
Description of Research Expertise
Mitral Valve DiseasePatent Foramen Ovale
Atrial Septal Defect
Structural heart disease
Valvular heart disease
Cardiac Imaging
Intracardiac Echocardiography
Interventional Echocardiography
Description of Clinical Expertise
Mitral Valve DiseasePatent Foramen Ovale
Atrial Septal Defect
Intracardiac Echocardiography
Interventional Echocardiography
Valvular heart disease
Preventitive cardiology
Lipid abnormalities
Metabolic syndrome
Selected Publications
Hahn RT, Makkar R, Thourani VH, Makar M, Sharma RP, Haeffele C, Davidson CJ, Narang A, O'Neill B, Lee J, Yadav P, Zahr F, Chadderdon S, Eleid M, Pislaru S, Smith R, Szerlip M, Whisenant B, Sekaran NK, Garcia S, Stewart-Dehner T, Thiele H, Kipperman R, Koulogiannis K, Lim DS, Fowler D, Kapadia S, Harb SC, Grayburn PA, Sannino A, Mack MJ, Leon MB, Lurz P, Kodali SK; TRISCEND II Trial Investigators.: Transcatheter Valve Replacement in Severe Tricuspid Regurgitation. N Engl J Med 392: 115-126, Jan 2025.Patel RB, Silvestry FE, Komtebedde J, Solomon SD, Hasenfuß G, Litwin SE, Borlaug BA, Price MJ, Kawash R, Hummel SL, Cutlip DE, Leon MB, van Veldhuisen DJ, Rieth AJ, McKenzie S, Bugger H, Mazurek JA, Kapadia SR, Vanderheyden M, Ky B, Shah SJ.: Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction: The REDUCE LAP-HF II Randomized Clinical Trial. JAMA Cardiol Apr 2024.
Kodali S, Hahn RT, Makkar R, Makar M, Davidson CJ, Puthumana JJ, Zahr F, Chadderdon S, Fam N, Ong G, Yadav P, Thourani V, Vannan MA, O'Neill WW, Wang DD, Tchétché D, Dumonteil N, Bonfils L, Lepage L, Smith R, Grayburn PA, Sharma RP, Haeffele C, Babaliaros V, Gleason PT, Elmariah S, Inglessis-Azuaje I, Passeri J, Herrmann HC, Silvestry FE, Lim S, Fowler D, Webb JG, Moss R, Modine T, Lafitte S, Latib A, Ho E, Goldberg Y, Shah P, Nyman C, Rodés-Cabau J, Bédard E, Brugger N, Sannino A, Mack MJ, Leon MB, Windecker S.: Transfemoral tricuspid valve replacement and one-year outcomes: the TRISCEND study. Eur Heart J 44: 4862-4873, Dec 2023.
Schaller RD, Vigdor A, Silvestry FE: Inadvertent left atrial injury during transseptal puncture with a radiofrequency-powered wire. J Interv Card Electrophysiol 66(7): 1561-1562, Oct 2023.
Writing Committee; Bass TA, Abbott JD, Mahmud E, Parikh SA, Aboulhosn J, Ashwath ML, Baranowski B, Bergersen L, Chaudry HI, Coylewright M, Denktas AE, Gupta K, Gutierrez JA, Haft J, Hawkins BM, Herrmann HC, Kapur NK, Kilic S, Lesser J, Lin CH, Mendirichaga R, Nkomo VT, Park LG, Phoubandith DR, Quader N, Rich MW, Rosenfield K, Sabri SS, Shames ML, Shernan SK, Skelding KA, Tamis-Holland J, Thourani VH, Tremmel JA, Uretsky S, Wageman J, Welt F, Whisenant BK, White CJ, Yong CM; ACC Competency Management Committee; Mendes LA, Arrighi JA, Breinholt JP 3rd, Day J, Dec GW Jr, Denktas AE, Drajpuch D, Faza N, Francis SA, Hahn RT, Housholder-Hughes SD, Khan SS, Kondapaneni MD, Lee KS, Lin CH, Hussain Mahar J, McConnaughey S, Niazi K, Pearson DD, Punnoose LR, Reejhsinghani RS, Ryan T, Silvestry FE, Solomon MA, Spicer RL, Weissman G, Werns SW.: 2023 ACC/AHA/SCAI advanced training statement on interventional cardiology (coronary, peripheral vascular, and structural heart interventions): A report of the ACC Competency Management Committee. J Thorac Cardiovasc Surg Jun 2023 Notes: Published online ahead of print.
Litwin SE, Komtebedde J, Hu M, Burkhoff D, Hasenfuß G, Borlaug BA, Solomon SD, Zile MR, Mohan RC, Khawash R, Sverdlov AL, Fail P, Chung ES, Kaye DM, Blair J, Eicher JC, Hummel SL, Zirlik A, Westenfeld R, Hayward C, Gorter TM, Demers C, Shetty R, Lewis G, Starling RC, Patel S, Gupta DK, Morsli H, Penicka M, Cikes M, Gustafsson F, Silvestry FE, Rowin EJ, Cutlip DE, Leon MB, Kitzman DW, Kleber FX, Shah SJ; REDUCE LAP-HF Investigators and Research Staff.: Exercise-Induced Left Atrial Hypertension in Heart Failure with Preserved Ejection Fraction. JACC Heart Fail S2213-1779(23): 00095-1, Mar 2023.
Gard EK, Beale AL, Telles F, Silvestry FE, Hanff T, Hummel SL, Litwin SE, Petrie MC, Shah SJ, Borlaug BA, Burkhoff D, Komtebedde J, Kaye DM, Nanayakkara S.: Left atrial enlargement is associated with pulmonary vascular disease in heart failure with preserved ejection fraction. Eur J Heart Fail Feb 2023.
Borlaug BA, Blair J, Bergmann MW, Bugger H, Burkhoff D, Bruch L, Celermajer DS, Claggett B, Cleland JGF, Cutlip DE, Dauber I, Eicher JC, Gao Q, Gorter TM, Gustafsson F, Hayward C, van der Heyden J, Hasenfuß G, Hummel SL, Kaye DM, Komtebedde J, Massaro JM, Mazurek JA, McKenzie S, Mehta SR, Petrie MC, Post MC, Nair A, Rieth A, Silvestry FE, Solomon SD, Trochu JN, Van Veldhuisen DJ, Westenfeld R, Leon MB, Shah SJ; REDUCE LAP-HF-II Investigators: Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure. Circulation 145(21): 1592-1604, May 24 2022.
Kodali S, Hahn RT, George I, Davidson CJ, Narang A, Zahr F, Chadderdon S, Smith R, Grayburn PA, O'Neill WW, Wang DD, Herrmann H, Silvestry F, Elmariah S, Inglessis I, Passeri J, Lim DS, Salerno M, Makar M, Mack MJ, Leon MB, Makkar R; TRISCEND Investigators: Transfemoral Tricuspid Valve Replacement in Patients With Tricuspid Regurgitation: TRISCEND Study 30-Day Results. JACC Cardiovasc Interv 15(5): 471-480, Mar 14 2022.
Webb J, Hensey M, Fam N, Rodés-Cabau J, Daniels D, Smith R, Szeto W, Boone R, Ye J, Moss R, Peterson M, Ong G, Paradis JM, Dagenais F, Wintzer-Wehekind J, Bilal S, Deepu N, Szerlip M, Grayburn P, Silvestry F, Koulogiannis K, Hermiller J, Guyton R, Herrmann H: Transcatheter Mitral Valve Replacement with the Transseptal EVOQUE System. J Am Coll Cardiol Intv 13(20): 2418-2426, Oct 2020.