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Frank E. Silvestry, MD
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Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
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Attending Physician, Hospital of the University of Pennsylvania
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Program Director, Cardiovascular Disease Fellowship Program, Hospital of the University of Pennsylvania
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Associate Chief for Education, Cardiovascular Division, Perelman School of Medicine
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Department: Medicine
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Contact information
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Division of Cardiovascular Medicine
22 11-133 South Pavilion PCAM
23 3400 Civic Center Boulevard
4d Hospital of the University of Pennsylvania
Philadelphia, PA 19104
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22 11-133 South Pavilion PCAM
23 3400 Civic Center Boulevard
4d Hospital of the University of Pennsylvania
Philadelphia, PA 19104
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Office: 2156208142
32 Fax: 215 349 8190
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32 Fax: 215 349 8190
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Publications
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Education:
21 9 B.S. 19 (Biochemistry) c
43 State University of New York at Binghamton, 1986.
21 9 M.D. 15 (Medicine) c
33 University of Pennsylvania, 1990.
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Permanent link21 9 B.S. 19 (Biochemistry) c
43 State University of New York at Binghamton, 1986.
21 9 M.D. 15 (Medicine) c
33 University of Pennsylvania, 1990.
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1c Patent Foramen Ovale
1c Atrial Septal Defect
21 Structural heart disease
1f Valvular heart disease
18 Cardiac Imaging
25 Intracardiac Echocardiography
26 Interventional Echocardiography
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1c Patent Foramen Ovale
1c Atrial Septal Defect
25 Intracardiac Echocardiography
27 Interventional Echocardiography
1e Valvular heart disease
1f Preventitive cardiology
1b Lipid abnormalities
19 Metabolic syndrome
1a 29
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Description of Research Expertise
25 Mitral Valve Disease1c Patent Foramen Ovale
1c Atrial Septal Defect
21 Structural heart disease
1f Valvular heart disease
18 Cardiac Imaging
25 Intracardiac Echocardiography
26 Interventional Echocardiography
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Description of Clinical Expertise
25 Mitral Valve Disease1c Patent Foramen Ovale
1c Atrial Septal Defect
25 Intracardiac Echocardiography
27 Interventional Echocardiography
1e Valvular heart disease
1f Preventitive cardiology
1b Lipid abnormalities
19 Metabolic syndrome
1a 29
23
241 Hahn RT, Makkar R, Thourani VH, Makar M, Sharma RP, Haeffele C, Davidson CJ, Narang A, O'Neill B, Lee J, Yadav P, Zahr F, Chadderdon S, Eleid M, Pislaru S, Smith R, Szerlip M, Whisenant B, Sekaran NK, Garcia S, Stewart-Dehner T, Thiele H, Kipperman R, Koulogiannis K, Lim DS, Fowler D, Kapadia S, Harb SC, Grayburn PA, Sannino A, Mack MJ, Leon MB, Lurz P, Kodali SK; TRISCEND II Trial Investigators.: Transcatheter Valve Replacement in Severe Tricuspid Regurgitation. N Engl J Med 392: 115-126, Jan 2025.
114 Petzl AM, Peters CJ, Frankel DS, Silvestry FE, Shivamurthy P.: Electrical instability and sudden loss of pacemaker capture-A tale of flecainide toxicity. HeartRhythm Case Rep. 11(1): 66-69, October 2024.
1f4 Patel RB, Silvestry FE, Komtebedde J, Solomon SD, Hasenfuß G, Litwin SE, Borlaug BA, Price MJ, Kawash R, Hummel SL, Cutlip DE, Leon MB, van Veldhuisen DJ, Rieth AJ, McKenzie S, Bugger H, Mazurek JA, Kapadia SR, Vanderheyden M, Ky B, Shah SJ.: Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction: The REDUCE LAP-HF II Randomized Clinical Trial. JAMA Cardiol Apr 2024.
2cc Kodali S, Hahn RT, Makkar R, Makar M, Davidson CJ, Puthumana JJ, Zahr F, Chadderdon S, Fam N, Ong G, Yadav P, Thourani V, Vannan MA, O'Neill WW, Wang DD, Tchétché D, Dumonteil N, Bonfils L, Lepage L, Smith R, Grayburn PA, Sharma RP, Haeffele C, Babaliaros V, Gleason PT, Elmariah S, Inglessis-Azuaje I, Passeri J, Herrmann HC, Silvestry FE, Lim S, Fowler D, Webb JG, Moss R, Modine T, Lafitte S, Latib A, Ho E, Goldberg Y, Shah P, Nyman C, Rodés-Cabau J, Bédard E, Brugger N, Sannino A, Mack MJ, Leon MB, Windecker S.: Transfemoral tricuspid valve replacement and one-year outcomes: the TRISCEND study. Eur Heart J 44: 4862-4873, Dec 2023.
105 Schaller RD, Vigdor A, Silvestry FE: Inadvertent left atrial injury during transseptal puncture with a radiofrequency-powered wire. J Interv Card Electrophysiol 66(7): 1561-1562, Oct 2023.
4a3 Writing Committee; Bass TA, Abbott JD, Mahmud E, Parikh SA, Aboulhosn J, Ashwath ML, Baranowski B, Bergersen L, Chaudry HI, Coylewright M, Denktas AE, Gupta K, Gutierrez JA, Haft J, Hawkins BM, Herrmann HC, Kapur NK, Kilic S, Lesser J, Lin CH, Mendirichaga R, Nkomo VT, Park LG, Phoubandith DR, Quader N, Rich MW, Rosenfield K, Sabri SS, Shames ML, Shernan SK, Skelding KA, Tamis-Holland J, Thourani VH, Tremmel JA, Uretsky S, Wageman J, Welt F, Whisenant BK, White CJ, Yong CM; ACC Competency Management Committee; Mendes LA, Arrighi JA, Breinholt JP 3rd, Day J, Dec GW Jr, Denktas AE, Drajpuch D, Faza N, Francis SA, Hahn RT, Housholder-Hughes SD, Khan SS, Kondapaneni MD, Lee KS, Lin CH, Hussain Mahar J, McConnaughey S, Niazi K, Pearson DD, Punnoose LR, Reejhsinghani RS, Ryan T, Silvestry FE, Solomon MA, Spicer RL, Weissman G, Werns SW.: 2023 ACC/AHA/SCAI advanced training statement on interventional cardiology (coronary, peripheral vascular, and structural heart interventions): A report of the ACC Competency Management Committee. J Thorac Cardiovasc Surg Jun 2023 Notes: Published online ahead of print.
2a3 Litwin SE, Komtebedde J, Hu M, Burkhoff D, Hasenfuß G, Borlaug BA, Solomon SD, Zile MR, Mohan RC, Khawash R, Sverdlov AL, Fail P, Chung ES, Kaye DM, Blair J, Eicher JC, Hummel SL, Zirlik A, Westenfeld R, Hayward C, Gorter TM, Demers C, Shetty R, Lewis G, Starling RC, Patel S, Gupta DK, Morsli H, Penicka M, Cikes M, Gustafsson F, Silvestry FE, Rowin EJ, Cutlip DE, Leon MB, Kitzman DW, Kleber FX, Shah SJ; REDUCE LAP-HF Investigators and Research Staff.: Exercise-Induced Left Atrial Hypertension in Heart Failure with Preserved Ejection Fraction. JACC Heart Fail S2213-1779(23): 00095-1, Mar 2023.
179 Gard EK, Beale AL, Telles F, Silvestry FE, Hanff T, Hummel SL, Litwin SE, Petrie MC, Shah SJ, Borlaug BA, Burkhoff D, Komtebedde J, Kaye DM, Nanayakkara S.: Left atrial enlargement is associated with pulmonary vascular disease in heart failure with preserved ejection fraction. Eur J Heart Fail Feb 2023.
2a3 Borlaug BA, Blair J, Bergmann MW, Bugger H, Burkhoff D, Bruch L, Celermajer DS, Claggett B, Cleland JGF, Cutlip DE, Dauber I, Eicher JC, Gao Q, Gorter TM, Gustafsson F, Hayward C, van der Heyden J, Hasenfuß G, Hummel SL, Kaye DM, Komtebedde J, Massaro JM, Mazurek JA, McKenzie S, Mehta SR, Petrie MC, Post MC, Nair A, Rieth A, Silvestry FE, Solomon SD, Trochu JN, Van Veldhuisen DJ, Westenfeld R, Leon MB, Shah SJ; REDUCE LAP-HF-II Investigators: Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure. Circulation 145(21): 1592-1604, May 24 2022.
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Selected Publications
20a Sannino A, Ilardi F, Hahn RT, Toufan M, Nickolite K, Agarwal V, Havens B, Ku I, Silvestry F, Weckbach L, Gleason P, Pretorius M, Ho E, Tulloch J, Ruf T, Cohen J, Duggal N, Sengupta PP, Kelly N, Chehab BM, Vogelhuber J, Vad S, Deuschl F, Thourani VH, Lurz P, Kodali SK, Grayburn PA.: Echocardiographic Imaging Considerations for Post-Implant Evaluation of the Transcatheter EVOQUE Tricuspid Valve Replacement System. JACC Cardiovasc Imaging Jul 2025.241 Hahn RT, Makkar R, Thourani VH, Makar M, Sharma RP, Haeffele C, Davidson CJ, Narang A, O'Neill B, Lee J, Yadav P, Zahr F, Chadderdon S, Eleid M, Pislaru S, Smith R, Szerlip M, Whisenant B, Sekaran NK, Garcia S, Stewart-Dehner T, Thiele H, Kipperman R, Koulogiannis K, Lim DS, Fowler D, Kapadia S, Harb SC, Grayburn PA, Sannino A, Mack MJ, Leon MB, Lurz P, Kodali SK; TRISCEND II Trial Investigators.: Transcatheter Valve Replacement in Severe Tricuspid Regurgitation. N Engl J Med 392: 115-126, Jan 2025.
114 Petzl AM, Peters CJ, Frankel DS, Silvestry FE, Shivamurthy P.: Electrical instability and sudden loss of pacemaker capture-A tale of flecainide toxicity. HeartRhythm Case Rep. 11(1): 66-69, October 2024.
1f4 Patel RB, Silvestry FE, Komtebedde J, Solomon SD, Hasenfuß G, Litwin SE, Borlaug BA, Price MJ, Kawash R, Hummel SL, Cutlip DE, Leon MB, van Veldhuisen DJ, Rieth AJ, McKenzie S, Bugger H, Mazurek JA, Kapadia SR, Vanderheyden M, Ky B, Shah SJ.: Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction: The REDUCE LAP-HF II Randomized Clinical Trial. JAMA Cardiol Apr 2024.
2cc Kodali S, Hahn RT, Makkar R, Makar M, Davidson CJ, Puthumana JJ, Zahr F, Chadderdon S, Fam N, Ong G, Yadav P, Thourani V, Vannan MA, O'Neill WW, Wang DD, Tchétché D, Dumonteil N, Bonfils L, Lepage L, Smith R, Grayburn PA, Sharma RP, Haeffele C, Babaliaros V, Gleason PT, Elmariah S, Inglessis-Azuaje I, Passeri J, Herrmann HC, Silvestry FE, Lim S, Fowler D, Webb JG, Moss R, Modine T, Lafitte S, Latib A, Ho E, Goldberg Y, Shah P, Nyman C, Rodés-Cabau J, Bédard E, Brugger N, Sannino A, Mack MJ, Leon MB, Windecker S.: Transfemoral tricuspid valve replacement and one-year outcomes: the TRISCEND study. Eur Heart J 44: 4862-4873, Dec 2023.
105 Schaller RD, Vigdor A, Silvestry FE: Inadvertent left atrial injury during transseptal puncture with a radiofrequency-powered wire. J Interv Card Electrophysiol 66(7): 1561-1562, Oct 2023.
4a3 Writing Committee; Bass TA, Abbott JD, Mahmud E, Parikh SA, Aboulhosn J, Ashwath ML, Baranowski B, Bergersen L, Chaudry HI, Coylewright M, Denktas AE, Gupta K, Gutierrez JA, Haft J, Hawkins BM, Herrmann HC, Kapur NK, Kilic S, Lesser J, Lin CH, Mendirichaga R, Nkomo VT, Park LG, Phoubandith DR, Quader N, Rich MW, Rosenfield K, Sabri SS, Shames ML, Shernan SK, Skelding KA, Tamis-Holland J, Thourani VH, Tremmel JA, Uretsky S, Wageman J, Welt F, Whisenant BK, White CJ, Yong CM; ACC Competency Management Committee; Mendes LA, Arrighi JA, Breinholt JP 3rd, Day J, Dec GW Jr, Denktas AE, Drajpuch D, Faza N, Francis SA, Hahn RT, Housholder-Hughes SD, Khan SS, Kondapaneni MD, Lee KS, Lin CH, Hussain Mahar J, McConnaughey S, Niazi K, Pearson DD, Punnoose LR, Reejhsinghani RS, Ryan T, Silvestry FE, Solomon MA, Spicer RL, Weissman G, Werns SW.: 2023 ACC/AHA/SCAI advanced training statement on interventional cardiology (coronary, peripheral vascular, and structural heart interventions): A report of the ACC Competency Management Committee. J Thorac Cardiovasc Surg Jun 2023 Notes: Published online ahead of print.
2a3 Litwin SE, Komtebedde J, Hu M, Burkhoff D, Hasenfuß G, Borlaug BA, Solomon SD, Zile MR, Mohan RC, Khawash R, Sverdlov AL, Fail P, Chung ES, Kaye DM, Blair J, Eicher JC, Hummel SL, Zirlik A, Westenfeld R, Hayward C, Gorter TM, Demers C, Shetty R, Lewis G, Starling RC, Patel S, Gupta DK, Morsli H, Penicka M, Cikes M, Gustafsson F, Silvestry FE, Rowin EJ, Cutlip DE, Leon MB, Kitzman DW, Kleber FX, Shah SJ; REDUCE LAP-HF Investigators and Research Staff.: Exercise-Induced Left Atrial Hypertension in Heart Failure with Preserved Ejection Fraction. JACC Heart Fail S2213-1779(23): 00095-1, Mar 2023.
179 Gard EK, Beale AL, Telles F, Silvestry FE, Hanff T, Hummel SL, Litwin SE, Petrie MC, Shah SJ, Borlaug BA, Burkhoff D, Komtebedde J, Kaye DM, Nanayakkara S.: Left atrial enlargement is associated with pulmonary vascular disease in heart failure with preserved ejection fraction. Eur J Heart Fail Feb 2023.
2a3 Borlaug BA, Blair J, Bergmann MW, Bugger H, Burkhoff D, Bruch L, Celermajer DS, Claggett B, Cleland JGF, Cutlip DE, Dauber I, Eicher JC, Gao Q, Gorter TM, Gustafsson F, Hayward C, van der Heyden J, Hasenfuß G, Hummel SL, Kaye DM, Komtebedde J, Massaro JM, Mazurek JA, McKenzie S, Mehta SR, Petrie MC, Post MC, Nair A, Rieth A, Silvestry FE, Solomon SD, Trochu JN, Van Veldhuisen DJ, Westenfeld R, Leon MB, Shah SJ; REDUCE LAP-HF-II Investigators: Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure. Circulation 145(21): 1592-1604, May 24 2022.
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