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Michael J. May, Ph.D.

Graduate Group Affiliations

Contact information
Department of Biomedical Sciences (OVH 200E),
The School of Veterinary Medicine,
The University of Pennsylvania
3800 Spruce Street, Philadelphia PA 19104.
Philadelphia, PA 19104
Office: (215) 573 0940
Fax: (215) 573 5186
Education:
B. Sc. (Department of Immunology)
University of Glasgow, UK, 1988.
M.Sc. (Department of Immunology)
University of Manchester, UK, 1992.
Ph.D. (Vascular Biology Research Centre)
King’s College London, UK. , 1996.
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Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention

CVI Research Description:
The major interest of our cardiovascular research is to understand how NF-kB signaling regulates the phenotype and function of vascular endothelial cells. The approaches my lab uses to address this include molecular and biochemical dissection of NF-kB signaling in cultured endothelial cells (including HUVEC, HDMEC and HAEC), conditional genetic deletion in endothelial cells of key kinases (IKK1± and IKK2) in the NF-kB pathway, and the development and testing of cell-permeable peptide inhibitors of NF-kB in vitro and in vivo.

We are particularly interested in understanding the role of the recently described non-canonical NF-kB pathway in regulating endothelial cell function in chronic inflammation and have an RO1 grant specifically addressing this question. In addition, my lab is currently examining both the classical and non-canonical NF-kB pathways in the context of atherosclerosis. We are using pharmacological (i.e. the cell-permeable NBD peptide that we developed) and genetic approaches to block NF-kB signaling in vivo in atherosclerosis-prone mice.

Selected Publications

Gray Carolyn M, Remouchamps Caroline, McCorkell Kelly A, Solt Laura A, Dejardin Emmanuel, Orange Jordan S, May Michael J: Noncanonical NF-κB Signaling Is Limited by Classical NF-κB Activity. Science Signaling 7(311): ra13, 2014.

Sehnert B, Burkhardt H, Wessels J T, Schröder Ag, May M J, Vestweber D, Zwerina J, Warnatz K, Nimmerjahn F, Schett G, Dübel S, Voll R E: NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases. Proceedings of the National Academy of Sciences of the United States of America 110(41): 16556-61, Oct 2013.

Neely R J, Brose M S, Gray C M, McCorkell K A, Leibowitz J M, Ma C, Rothstein J L & May M J: The RET/PTC3 oncogene activates classical NF-kappaB by stabilizing NIK. Oncogene 6(30): 87-96, 2011.

Madge LA & May MJ: Classical NF-kappaB activation negatively regulates non-canonical NF-kappaB-dependent CXCL12 expression. The Journal of biological chemistry 285 (49): 38069-077, 2010.

Yatherajam G, Banerjee PP, McCorkell KA, Solt LA, Hanson EP, Madge LA, Kang S, Worley PF, Orange JS & May MJ.: Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3. Journal of immunology 185(5): 2665-9, 2010.

Solt LA, Madge LA & May MJ: NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation. The Journal of biological chemistry 284(40): 27596-608, 2009.

Wharry CE, Haines KM, Carroll RG & May MJ.: Constitutive non-canonical NFkappaB signaling in pancreatic cancer cells. Cancer biology & therapy 8(16): 1567-76, 2009.

Madge LA, Kluger MS, Orange JS & May MJ.: Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells. Journal of Immunology 180(5): 3467-77, 2008.

May MJ & Madge LA.: Caspase inhibition sensitizes inhibitor of NF-kappaB kinase beta-deficient fibroblasts to caspase-independent cell death via the generation of reactive oxygen species. Journal of Biological Chemistry 282(22): 16105-16, 2007.

Solt LA, Madge LA, Orange JS & May MJ.: Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta. Journal of Biological Chemistry 282(12): 8724-33, 2007.

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Last updated: 07/28/2015
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