Wayne William Hancock, MD, PhD, FRCPA
Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
916B Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
Office: (215) 590-8709
Fax: (215) 590-7384
Fax: (215) 590-7384
Email:
whancock@mail.med.upenn.edu
whancock@mail.med.upenn.edu
Publications
Education:
M.B.B.S. (Medicine)
Monash University, Clayton, Victoria, Australia, 1977.
Ph.D. (Medicine)
Monash University, Clayton, Victoria, Australia, 1984.
F.R.C.P.A. (Pathology)
Royal College o fPathologists of Australasia, 1989.
Permanent linkM.B.B.S. (Medicine)
Monash University, Clayton, Victoria, Australia, 1977.
Ph.D. (Medicine)
Monash University, Clayton, Victoria, Australia, 1984.
F.R.C.P.A. (Pathology)
Royal College o fPathologists of Australasia, 1989.
Description of CVI Expertise
CVI Program Unit(s):Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging
Thrombosis / Hemostasis
CVI Research Description:
I am interested in immunologic and inflammatory events affecting the cardiovascular system, with particular interest in replacement therapies, whether by manipulation of stem cells or through cardiac transplantation. Optimizing outcomes of cardiac transplantation is another special interest.
Selected Publications
de Zoeten EF, Wang L, Butler K, Beier UH, Akimova T, Sai H, Bradner JE, Mazitschek R, Kozikowski AP, Matthias P, Hancock WW. : Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3+ T-regulatory cells. Molecular and Cellular Biology 31: 2066-2078, 2011.Beier UH, Wang L, Bhatti TR, Liu Y, Han R, Ge G, Hancock WW. : Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Molecular and Cellular Biology 31: 1022-1029, 2011.
Akimova TA, Ge G, Golovina TA, Mikheeva T, Wang L, Riley JL, Hancock WW.: Histone/protein deacetylase inhibitors increase the suppressive functions of human FOXP3+ Tregs. Clinical Immunology Page: 348-363, 2010.
de Zoeten EF, Wang L, Sai H, Dillmann WH, Hancock WW.: Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology 138: 583-594, 2010.
Waaga-Gasser AM, Grimm MR, Lutz J, Lange V, Lenhard SM, Aviles B, Kist-van Holthe JE, Lebedeva T, Samsonov D, Meyer D, Hancock WW, Heemann U, Gasser M, Chandraker A.: Regulatory allospecific T cell clones abrogate chronic allograft rejection. Journal of the American Society of Nephrology 20: 820-30, 2009.
Truong W, Hancock WW, Plester JC, Merani S, Rayner DC, Thangavelu G, Murphy KM, Anderson CC, Shapiro AM.: BTLA targeting modulates lymphocyte phenotype, function, and numbers and attenuates disease in non-obese diabetic mice. Journal of Leukocyte Biology 86: 758-772, 2009.
de Zoeten EF, Lee I, Wang L, Chen C, Ge G, Wells AD, Hancock WW, Ozkaynak E.: Foxp3 processing by proprotein convertases and control of regulatory T cell function. J Biol Chem 284: 5709-16, 2009.
de Jonge J, Kurian S, Shaked A, Reddy KR, Hancock WW, Salomon DR, Olthoff KM.: Unique early gene expression patterns in human adult-to-adult living donor liver grafts compared to deceased donor grafts. American Journal of Transplantation 9: 758-72, 2009.
Saouaf SJ, Li B, Zhang G, Shen Y, Furuuchi N, Hancock WW, Greene MI.: Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis. Experimental and Molecular Pathology 87: 99-104, 2009.
Hoffman SA, Wang L, Shah CV, Ahya VN, Pochettino A, Olthoff K, Shaked A, Wille K, Lama VN, Milstone A, Ware LB, Orens J, Weinacker A, Demissie E, Bellamy S, Kawut SM, Hancock WW, Christie JD: Plasma cytokines and chemokines in primary graft dysfunction post-lung transplantation. Am J Transplant 9: 389-96, 2009.