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Wayne William Hancock, MB.BS, PhD, FRCPA

Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
916B Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
Office: (215) 590-8709
Fax: (215) 590-7384
Education:
M.B.B.S. (Medicine)
Monash University, Clayton, Victoria, Australia, 1977.
Ph.D. (Medicine)
Monash University, Clayton, Victoria, Australia, 1984.
F.R.C.P.A. (Pathology)
Royal College o fPathologists of Australasia, 1989.
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Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging
Thrombosis / Hemostasis

CVI Research Description:
I am interested in immunologic and inflammatory events affecting the cardiovascular system, with particular interest in replacement therapies, whether by manipulation of stem cells or through cardiac transplantation. Optimizing outcomes of cardiac transplantation is another special interest.

Selected Publications

Negorev D, Beier UH, Zhang T, Quatromoni JG, Bhojnagarwala P, Albelda SM, Singhal S, Eruslanov E, Lohoff FW, Levine MH, Diamond JM, Christie JD, Hancock WW, Akimova T.: Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms. Scientific Reports 8(1): 3135, February 2018.

Xu H, Dahiya S, Wang L, Akimova T, Han R, Zhang T, Zhang Y, Qin L, Levine MH, Hancock WW, Levin LS.: Utility of IL-2 complexes in promoting the survival of murine orthotopic forelimb vascularized composite allografts. Transplantation 102: 70-78, January 2018.

Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA.: Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nature Communications 9: 53, January 2018.

Wang F, Wang L, Wu J, Sokirniy I, Nguyen P, Bregnard T, Weinstock J, Mattern M, Bezsonova I, Hancock WW, Kumar S.: Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60. PLoS One Page: e0189744, December 2017.

Huang J, Wang L, Dahiya S, Beier UH, Han R, Samanta A, Bergman J, Sotomayor EM, Seto E, Kozikowski AP, Hancock WW.: Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Scientific Reports 17: 8626, August 2017.

Akimova T, Zhang T, Negorev D, Singhal S, Stadanlick J, Rao A, Annunziata M, Levine MH, Beier UH, Diamond JM, Christie JD, Albelda SM, Eruslanov EB, Hancock WW.: Human lung tumor FOXP3+ Tregs upregulate four "Treg-locking" transcription factors. JCI Insight Page: pii: 94075, August 2017.

Woods DM, Woan K, Wang D, Sodré AL, Cheng F, Wang Z, Chen J, Powers J, Pinilla-Ibarz J, Yu Y, Weber J, Hancock WW, Seto E, Villagra A, Yu XZ, Sotomayor EM.: T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model. Blood 130: 146-155, July 2017.

Laskin BL, Jiao J, Baluarte HJ, Amaral S, Furth SL, Akimova T, Hancock WW, Levine MH, Reese PP, Beier UH.: The Effects of Tacrolimus on T-Cell Proliferation Are Short-Lived: A Pilot Analysis of Immune Function Testing. Transplantation Direct 3: e199, July 2017.

Bin Dhuban K, d'Hennezel E, Nagai Y, Xiao Y, Shao S, Istomine R, Alvarez F, Ben-Shoshan M, Ochs H, Mazer B, Li B, Sekine C, Berezov, A, Hancock W, Torgerson TR, Greene M I, Piccirillo CA.: Suppression by human FOXP3+ regulatory T cells requires FOXP3-TIP60 interactions. Science Immunology 2,: eaai9297, June 2017.

Angelin A, De Gomez LG, Dahiya S, Jiao J, Guo L, Wang L, Akimova T, Liu Y, Bhatti TR, Han R, Wang W, Laskin BL, Blair IA, Wallace DC, Hancock WW, Beier UH. : Foxp3 reprograms T cell metabolism to function in low glucose high lactate environments. Cell Metabolism 25: 1282-1293, June 2017.

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Last updated: 02/19/2018
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