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Wayne William Hancock, MB.BS, PhD, FRCPA

Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
916B Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
Office: (215) 590-8709
Fax: (215) 590-7384
Education:
M.B.B.S. (Medicine)
Monash University, Clayton, Victoria, Australia, 1977.
Ph.D. (Medicine)
Monash University, Clayton, Victoria, Australia, 1984.
F.R.C.P.A. (Pathology)
Royal College o fPathologists of Australasia, 1989.
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Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging
Thrombosis / Hemostasis

CVI Research Description:
I am interested in immunologic and inflammatory events affecting the cardiovascular system, with particular interest in replacement therapies, whether by manipulation of stem cells or through cardiac transplantation. Optimizing outcomes of cardiac transplantation is another special interest.

Selected Publications

Jiao J, Han R, Hancock WW, Beier UH. : Proximity ligation assay to quantify Foxp3 acetylation in regulatory T cells. Methods in Molecular Biology 1510: 287-293, January 2017.

Woods DM, Woan K, Wang D, Sodré AL, Cheng F, Wang Z, Chen J, Powers J, Pinilla-Ibarz J, Yu Y, Weber J, Hancock WW, Seto E, Villagra A, Yu XZ, Sotomayor EM.: Histone deacetylase 11 is an epigenetic regulator of Eomes and Tbet expression in T-cells. Blood In press, 2017.

Angelin A, De Gomez LG, Dahiya S, Jiao J, Guo L, Wang L, Akimova T, Liu Y, Bhatti TR, Han R, Wang W, Laskin BL, Blair IA, Wallace DC, Hancock WW, Beier UH. : Foxp3 reprograms T cell metabolism to function in low glucose high lactate environments. Cell Metabolism In press, 2017.

Lama VN, Belperio JA, Christie JD, El-Chemaly S, Fishbein MC, Gelman AE, Hancock WW, Keshavjee S, Kreisel D, Laubach VE, Looney MR, McDyer JF, Mohanakumar T, Shilling RA, Panoskaltsis-Mortari A, Wilkes DS, Eu JP, Nicolls MR.: NHLBI Workshop Report: Animal Models of Lung Transplant Research JCI Insight In press, 2017.

Wang L, Kumar S, Dahiya S, Wang F, Wu J, Newick K, Han R, Samanta A, Beier UH, Akimova T, Bhatti TR, Nicholson B, Kodrasov MP, Agarwal S, Sterner DE, Gu W, Weinstock J, Butt TR, Albelda SM, Hancock WW.: Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity. EBioMedicine 13: 99-112, November 2016.

Hancock WW. : Isoform-selective HDAC inhibitor therapy for transplantation: Are we ready for HDAC6? Transplantation 100(8): 1597-98, August 2016.

Akimova T, Levine MH, Beier UH, Hancock WW. : Standardization, evaluation and area-under-curve analysis of human and murine Treg suppressive function. Methods in Molecular Biology 1371: 43-78, July 2016.

Singhal S, Bhojnagarwala PS, O'Brien S, Moon EK, Garfall AL, Rao AS, Quatromoni JG, Stephen TL, Litzky L, Deshpande C, Feldman MD, Hancock WW, Conejo-Garcia JR, Albelda SM, Eruslanov EB.: Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer. Cancer Cell 30(1): 120-135, July 2016.

Levine MH, Wang Z, Xiao H, Jiao J, Wang L, Bhatti TR, Hancock WW, Beier UH.. : Targeting Sirtuin-1 prolongs murine renal allograft survival and function. Kidney International 89(5): 1016-1026, May 2016.

Aufhauser DA, Wang Z, Bhatti TR, Wang Y, Ge G, Redfield RR, Abt PL, Wang L, Thomasson A, Reese P, Hancock WW, Levine MH. : Improved renal ischemia tolerance in females influences kidney transplantation outcomes. Journal of Clinical Investigation 126(5): 1968-1977, May 2016.

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Last updated: 08/29/2017
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