Wayne William Hancock, MD, PhD, FRCPA
Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
916B Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
Office: (215) 590-8709
Fax: (215) 590-7384
Fax: (215) 590-7384
Email:
whancock@mail.med.upenn.edu
whancock@mail.med.upenn.edu
Publications
Education:
M.B.B.S. (Medicine)
Monash University, Clayton, Victoria, Australia, 1977.
Ph.D. (Medicine)
Monash University, Clayton, Victoria, Australia, 1984.
F.R.C.P.A. (Pathology)
Royal College o fPathologists of Australasia, 1989.
Permanent linkM.B.B.S. (Medicine)
Monash University, Clayton, Victoria, Australia, 1977.
Ph.D. (Medicine)
Monash University, Clayton, Victoria, Australia, 1984.
F.R.C.P.A. (Pathology)
Royal College o fPathologists of Australasia, 1989.
Description of CVI Expertise
CVI Program Unit(s):Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging
Thrombosis / Hemostasis
CVI Research Description:
I am interested in immunologic and inflammatory events affecting the cardiovascular system, with particular interest in replacement therapies, whether by manipulation of stem cells or through cardiac transplantation. Optimizing outcomes of cardiac transplantation is another special interest.
Selected Publications
Wang L, Fraser CC, Kikly K, Wells AD, Han R, Coyle AJ, Chen L, Hancock WW: B7-H3 promotes acute and chronic allograft rejection. European Journal of Immunology 35: 428-438, 2005.Gasser M, Waaga-Gasser AM, Grimm MW, Grimm MR, Lenhard MS, Kist-van Holthe JE, Laskowski I, Shaw GD, Thiede A, Hancock WW, Tilney NL: Selectin blockade plus therapy with low-dose sirolimus and cyclosporin A prevent brain death-induced renal allograft dysfunction. American Journal of Transplantation 5: 662-670, 2005.
Luo X, Yang H, Kim IS, Sainte-Hilaire F, Thomas DA, De BP, Ozkaynak E, Muthukumar T, Hancock WW, Crystal RG, Suthanthiran M.: Systemic transforming growth factor-β1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice. Transplantation 79: 1091-1096, 2005.
Lee I, Wang L, Wells AD, Dorf ME, Ozkaynak E, Hancock WW: Recruitment of Foxp3+ T-regulatory cells mediating allograft tolerance depends upon the CCR4 chemokine receptor. Journal of Experimental Medicine 201: 1037-1044, 2005.
Karni A, Balashov K, Hancock WW, Bharanidharan P, Abraham M, Khoury SJ, Weiner HL: Cyclophosphamide modulates CD4(+) T cells into a T helper type 2 phenotype and reverses increased IFN-gamma production of CD8(+) T cells in secondary progressive multiple sclerosis. Journal of Neuroimmunology 146: 189-198, 2004.
Wu Z, Bensinger SJ, Zhang J, Chen C, Yuan X, Huang X, Markmann JF, Kassaee A, Rosengard BR, Hancock WW, Sayegh MH, Turka LA.: Homeostatic proliferation is a barrier to transplantation tolerance. Nature Medicine 10: 87-92, 2004.
Pratschke J, Paz D, Wilhelm MJ, Laskowski I, Kofla G, Vergopoulos A, MacKenzie HJ, Tullius SG, Neuhaus P, Hancock WW, Volk HD, Tilney NL.: Donor hypertension increases graft immunogenicity and intensifies chronic changes in long-surviving renal allografts. Transplantation 77: 43-48, 2004.
Mata M, Chiffoleau E, Adler SH, Gray T, Hancock WW, Turka LA.: Bcl-XL expression in stem cells facilitates engraftment and reduces the need for host conditioning during bone marrow transplantation. American Journal of Transplantation 4: 58-64, 2004.
Hancock WW, Szaba FM, Berggren KN, Parent MA, Mullarky IK, Pearl J, Cooper AM, Ely KH, Woodland DL, Kim IJ, Blackman MA, Johnson LL, Smiley ST.: Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN-g-inducible fibrinogen-like protein 2. Proceedings of the National Academy of Sciences USA 101: 3005-3010, 2004.
Nanji SA, Hancock WW, Anderson CC, Adams AB, Luo B, Schur CD, Pawlick RL, Wang L, Coyle AJ, Larsen CP, Shapiro AMJ.: Multiple combination therapies involving blockade of ICOS/B7RP-1 costimulation facilitate long-term islet allograft survival. American Journal of Transplantation 4: 526-536, 2004.
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