Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

David M. Eckmann, PhD, MD

Horatio C. Wood Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
331 John Morgan Building/6112
3620 Hamilton Walk
Philadelphia, PA 19104-6802
Office: 215-349-5348
Fax: 215-349-5078
Education:
B.S. (Bioengineering)
University of California, San Diego, 1983.
Ph.D. (Biomedical Engineering)
Northwestern University, 1989.

Medical Scientist Training Program, Northwestern University, 1990.
M.D. (Medicine)
Northwestern University, 1990.
M.A. (Education (Honorary))
University of Pennsylvania, 2003.
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Description of CVI Expertise

CVI Program Unit(s):
Biotechnology / Nanomedicine / Imaging
Thrombosis / Hemostasis

CVI Research Description:

My current cardiovascular research interests fall into 3 areas:

1. Biomimetic macromolecular surface grafting for biocompatibility of vascular biomaterials. We are making biomimetic surface molecular constructs of biomolecules (e.g., hyaluronic acid, dextrans) on solid substrates (e.g., vascular stents, grafts, catheters, extracorporeal perfusion circuits) to improve biocompatibility and reduce bioresponses to blood contact to coated biomaterials.

2. Molecular basis for neuroprotection in cerebrovascular gas embolism. We are investigating the role of exogenous surfactants in altering mechanotransduction and cell signaling events to attenuate endothelial cell injury/death and mitigate CNS injury in cerebrovascular gas embolism occurring in cardiac surgery, decompression sickness and other gas embolism-risk activities.

3. Optimization of nanocarrier design for targeted vascular drug delivery. We are using a combination of experimental and computational techniques to assess the influence of design parameters (e.g., carrier size, shape, surface density of targeting binding molecules) to optimize carrier binding to vascular endothelium for targeted drug delivery.

Selected Publications

Coll Ferrer, M.C., Zern, B., Composto, R.J., Muzykantov, V.R., Eckmann, D.M.: ICAM-1 targeted nanogels loaded with dexamethasone alleviate pulmonary inflammation. PLoS ONE 9(7): e102329, July 2014.

Kandel, J., Lee, H.S., Sobolewski, P., Tomczyk, N., Composto, R.J., Eckmann, D.M.: Chemically grafted fibronectin for use in QCM-D cell studies. Biosensors and Bioelectronics 58: 249-257, February 2014.

Lee, H.S., Stachelek, S.J., Tomczyk, N., Composto, R.J., Eckmann, D.M.: Correlating macrophage morphology and cytokine production resulting from biomaterial contact. Journal of Biomedical Materials Research Part A 101(1): 203-212, January 2013.

Sobolewski, P., Kandel, J., Eckmann, D.M.: Air bubble contact with endothelial cells causes a calcium-independent loss in mitochondrial membrane potential. PLoS ONE 7(10): e47254, October 2012.

Lee, H.S., Yee, M.Q., Eckmann, Y.Y., Hickok, N.J., Eckmann, D.M., Composto, R.J.: Tuning the swelling of chitosan brushes by varying quaternary ammonium salt content and counterion type. Journal of Materials Chemistry 22: 19605-19616, September 2012.

Coll Ferrer, M.C., Hickok, N.J., Eckmann, D.M., Composto, R.J.: Antibacterial biomimetic hybrid films. Soft Matter 8: 2423-2431, February 2012.

Calderon, A.J., Bhowmick, T., Leferovich, J., Burman, B., Pichette, B., Muzykantov, V.N., Eckmann, D.M.*, Muro, S.*: Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers. Journal of Controlled Release 150: 37-44, February 2011 Notes: *equal contributions as corresponding authors.

Sobolewski, P., Kandel, J., Klinger, A.L., Eckmann, D.M.: Air bubble contact with endothelial cells in vitro induces calcium influx and IP3-dependent release of calcium stores. American Journal of Physiology - Cell Physiology 301(3): C679-C686, August 2011.

Stachelek, S.J., Finley, M.J., Alferiev, I., Wang, F., Tsai, R., Eckells, E.C., Tomczyk, N., Connolly, J.M., Discher, D.E., Eckmann, D.M., Levy, R.J.: The effect of CD 47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials 32: 4317-4326, July 2011.

Liu, J., Weller, G.E.R., Zern, B., Ayyaswamy, P.S., Eckmann, D.M., Muzykantov, V., Radhakrishnan, R.: A computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and Atomic Force Microscopy experiments. Proceedings of the National Academy of Sciences 107(38): 16530-16535, September 2010.

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Last updated: 12/03/2014
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