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David M. Eckmann, PhD, MD

Horatio C. Wood Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
331 John Morgan Building/6112
3620 Hamilton Walk
Philadelphia, PA 19104-6802
Office: 215-349-5348
Fax: 215-349-5078
Education:
B.S. (Bioengineering)
University of California, San Diego, 1983.
Ph.D. (Biomedical Engineering)
Northwestern University, 1989.
M.D. (Medicine)
Northwestern University, 1990.

Medical Scientist Training Program, Northwestern University, 1990.
M.A. (Education (Honorary))
University of Pennsylvania, 2003.
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Description of CVI Expertise

CVI Program Unit(s):
Biotechnology / Nanomedicine / Imaging
Thrombosis / Hemostasis

CVI Research Description:

My current cardiovascular research interests fall into 3 areas:

1. Biomimetic macromolecular surface grafting for biocompatibility and anti-infectivity of vascular biomaterials. We are making biomimetic surface molecular constructs of biomacromolecules having bioresponsive swelling properties for drug elution. These thin film layers can be grafted onto solid substrates (e.g., vascular stents, grafts, catheters, extracorporeal perfusion circuits) to improve biocompatibility and reduce bioresponses to blood contact to coated biomaterials as well as to resist and respond to bacterial biofilm formation.

2. Cellular metabolic engineering. We are examining the relationship between cellular metabolic function and cellular mechanical function. Our goal is to understand mitochondrial function and cellular bioenergetics in the face of cellular mechanical dysfunction and to understand maintenance of cellular mechanical homeostasis when cellular metabolic capacity becomes stressed.

3. Optimization of nanocarrier design for targeted vascular drug delivery. We are using a combination of experimental and computational techniques to assess the influence of design parameters (e.g., carrier type, size, shape, surface density of targeting binding molecules) to optimize carrier binding to vascular endothelium for targeted drug delivery.

Selected Publications

Kandel, J., Picard, M., Wallace, D.C., Eckmann, D.M.: MtDNA 3243A>G heteroplasmy is associated with changes in cytoskeletal protein expression and cell mechanics. Journal of the Royal Society Interface 14: 20170071, May 2017.

Grady, M.E., Parrish, E., Seeger, S., Caporizzo, M.A., Composto, R.J.*, Eckmann, D.M.*: Intracellular nanoparticle dynamics affected by cytoskeletal integrity. Soft Matter 13: 1873-1880, February 2017 Notes: *Equal contributions as senior author.

Grady, M.E., Composto, R.J., Eckmann, D.M. : Cell elasticity with altered cytoskeletal architectures across multiple cell types. Journal of Mechanical Behavior of Biomedical Material 61: 197-207, August 2016 Notes: Video author presentation: http://www.sciencedirect.com/science/article/pii/S1751616116000254.

Kandel, J., Angelin, A.A., Wallace, D.C., Eckmann, D.M. : Mitochondrial respiration is sensitive to cytoarchitectural breakdown. Integrative Biology 8: 1170-1182, November 2016.

Kandel, J., Chou, P., Eckmann, D.M.: Automated detection of whole-cell mitochondrial motility and its dependence on cytoarchitectural integrity. Biotechnology & Bioengineering 112(7): 1395-1405, July 2015.

Lee, H.S., Dastgheyb, S.S., Hickok, N.J., Eckmann, D.M.,* Composto, R.J.*: Controlled and localized release of Tobramycin from a stimuli-responsive grafted bilayer challenged with S. aureus. Biomacromolecules 16(2): 650-659, January 2015 Notes: *Equal contributions as senior author.

Coll Ferrer, M.C., Zern, B., Composto, R.J., Muzykantov, V.R., Eckmann, D.M.: ICAM-1 targeted nanogels loaded with dexamethasone alleviate pulmonary inflammation. PLoS ONE 9(7): e102329, July 2014.

Kandel, J., Lee, H.S., Sobolewski, P., Tomczyk, N., Composto, R.J., Eckmann, D.M.: Chemically grafted fibronectin for use in QCM-D cell studies. Biosensors and Bioelectronics 58: 249-257, February 2014.

Lee, H.S., Stachelek, S.J., Tomczyk, N., Composto, R.J., Eckmann, D.M.: Correlating macrophage morphology and cytokine production resulting from biomaterial contact. Journal of Biomedical Materials Research Part A 101(1): 203-212, January 2013.

Coll Ferrer, M.C., Hickok, N.J., Eckmann, D.M., Composto, R.J.: Antibacterial biomimetic hybrid films. Soft Matter 8: 2423-2431, February 2012.

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Last updated: 11/07/2017
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