Mark A Oyama, DVM, MSCE, DACVIM

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Professor of Cardiology
Professor, Department of Clinical Sciences & Advanced Medicine, University of Pennsylvania School of Veterinary Medicine
Charlotte Newton Sheppard Endowed Chair of Medicine, University of Pennsylvania School of Veterinary Medicine
Chair, Department of Clinical Sciences & Advanced Medicine, University of Pennsylvania School of Veterinary Medicine
Associate Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania
Department: Cardiology

Contact information
Department of Clinical Studies-Philadelphia
Ryan Veterinary Hospital of the University of Pennsylvania
School of Veterinary Medicine
University of Pennsylvania
3900 Spruce St.
Philadelphia, PA 19104
Office: 215-898-3331
Education:
DVM (Doctor Veterinary Medicine)
University of Illinois, 1994.
MSCE (Masters of Science in Clinical Epidemiology)
University of Pennslyvania, 2015.
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Description of Research Expertise

Cardiac biomarkers (troponin, natriuretic peptides [BNP, ANP])
Diuretic resistance
Clinical trials
Serotonin signaling and myxomatous valve disease
Animal models of heart disease and heart failure
Epidemiology and biostatistics

Description of Clinical Expertise

Canine and feline models of heart disease
Molecular mechanisms of myxomatous mitral valve disease
Diuretic resistance
Epidemiology and biostatistics

Selected Publications

Tinsley AT, Oyama MA, Reineke EL.: Animal Trauma Triage Score, Modified Glasgow Coma Scale, age, and weight were associated with outcome in feline bite wounds (1,065 cases): a VetCOT registry study. J Am Vet Med Assoc 261: 881-887, Mar 2023.

Castillero E, Fitzpatrick E, Keeney SJ, D'Angelo AM, Pressly BB, Simpson MT, Kurade M, Erwin WC, Moreno V, Camillo C, Shukla HJ, Inamdar VV, Aghali A, Grau JB, Salvati E, Nissim I, Rauova L, Oyama MA, Stachelek SJ, Brown C, Krieger AM, Levy RJ, Ferrari G.: Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation. Sci Transl Med 15: eadc9606, Jan 2023.

Oyama MA, Adin D.: Toward quantification of loop diuretic responsiveness for congestive heart failure. J Vet Intern Med 2023.

Pedro B, Mavropoulou A, Oyama MA, Linney C, Neves J, Dukes-McEwan J, Fontes-Sousa AP, Gelzer AR.: Optimal rate control in dogs with atrial fibrillation-ORCA study-Multicenter prospective observational study: Prognostic impact and predictors of rate control. J Vet Intern Med 2023.

Li Q, Larouche-Lebel É, Loughran KA, Huh TP, Suchodolski JS, Oyama MA.: Metabolomics Analysis Reveals Deranged Energy Metabolism and Amino Acid Metabolic Reprogramming in Dogs With Myxomatous Mitral Valve Disease. J Am Heart Assoc 10: e018923, May 2021.

Li Q, Larouche-Lebel É, Loughran KA, Huh TP, Suchodolski JS, Oyama MA.: Gut Dysbiosis and Its Associations with Gut Microbiota-Derived Metabolites in Dogs with Myxomatous Mitral Valve Disease. mSystems 6: e00111-21, Apr 2021.

Crooks AV, Gelzer AR, Oyama MA, Kraus MS.: Quiet timer blanking in a dog with sick sinus syndrome and a permanent transvenous pacemaker. J Vet Cardiol 2021.

Larouche-Lebel É, Loughran KA, Huh T, Oyama MA.: Effect of angiotensin receptor blockers and angiotensin converting enzyme 2 on plasma equilibrium angiotensin peptide concentrations in dogs with heart disease. J Vet Intern Med 2021.

Oyama MA, Gelzer AR, Kraus MS.: Letter regarding "Efficacy of adding ramipril (VAsotop) to the combination of furosemide (Lasix) and pimobendan (VEtmedin) in dogs with mitral valve degeneration: The VALVE trial" J Vet Intern Med 2021.

Wilshaw J, Rosenthal SL, Wess G, Dickson D, Bevilacqua L, Dutton E, Deinert M, Abrantes R, Schneider I, Oyama MA, Gordon SG, Elliott J, Xia D, Boswood A.: Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease. J Vet Intern Med 2021.

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Last updated: 06/12/2023
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