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Professor of Cardiology
Professor, Department of Clinical Sciences & Advanced Medicine, University of Pennsylvania School of Veterinary Medicine
Charlotte Newton Sheppard Endowed Chair of Medicine, University of Pennsylvania School of Veterinary Medicine
Chair, Department of Clinical Sciences & Advanced Medicine, University of Pennsylvania School of Veterinary Medicine
Associate Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania
Department: Cardiology

Contact information
Department of Clinical Studies-Philadelphia
Ryan Veterinary Hospital of the University of Pennsylvania
School of Veterinary Medicine
University of Pennsylvania
3900 Spruce St.
Philadelphia, PA 19104
Office: 215-898-3331
DVM (Doctor Veterinary Medicine)
University of Illinois, 1994.
MSCE (Masters of Science in Clinical Epidemiology)
University of Pennslyvania, 2015.
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Description of Research Expertise

Cardiac biomarkers (troponin, natriuretic peptides [BNP, ANP])
Diuretic resistance
Clinical trials
Serotonin signaling and myxomatous valve disease
Animal models of heart disease and heart failure
Epidemiology and biostatistics

Description of Clinical Expertise

Canine and feline models of heart disease
Molecular mechanisms of myxomatous mitral valve disease
Diuretic resistance
Epidemiology and biostatistics

Selected Publications

Pedro B, Dukes-McEwan J, Oyama MA, Kraus MS, Gelzer AR: Retrospective evaluation of the effect of heart rate on survival in dogs with atrial fibrillation. J Vet Intern Med Dec 2017 Notes: doi: 10.1111/jvim.14885.

Wallner M, Eaton DM, Berretta RM, Borghetti G. Wu J, Baker ST, Feldstott EA, Shart TE, Mohsin S, Oyama MA, von Lewinski D, Wolfson MR, Houser SR: A feline HFpEF model with pulmonary hypertension and compromised pulmonary function. Sci Rep 29: 16587, Nov 2017.

Oyama MA, Ellenberg SS, Shaw PA: Clinical trials in veterinary medicine: a new era brings new challenges. J Vet Intern Med 31: 970-978, Jul 2017.

Oyama MA, Solter PF, Thorn CL, Stern JA: Feasibility, safety, and tolerance of subcutaneous synthetic canine B-type natriuretic peptide (syncBNP) in healthy dogs and dogs with stage B1 mitral valve disease. J Vet Cardiol 19: 211-217, Jun 2017.

Hezzell M J, Rush J E, Humm K, Rozanski E A, Sargent J, Connolly D J, Boswood A, Oyama M A: Differentiation of Cardiac from Noncardiac Pleural Effusions in Cats using Second-Generation Quantitative and Point-of-Care NT-proBNP Measurements. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 30(2): 536-42, Mar 2016.

Solter Philip F, Oyama Mark A, Machen Maggie C, Trafny Dennis J, Sisson D David: Detection by ELISA of C-terminal proBNP in plasma from cats with cardiomyopathy. Veterinary journal (London, England : 1997) 206(2): 213-7, Nov 2015.

Pouchelon J L, Atkins C E, Bussadori C, Oyama M A, Vaden S L, Bonagura J D, Chetboul V, Cowgill L D, Elliot J, Francey T, Grauer G F, Fuentes V Luis, Moise N Sydney, Polzin D J, Van Dongen A M, Van Israƫl N: Cardiovascular-renal axis disorders in the domestic dog and cat: a veterinary consensus statement. The Journal of small animal practice 56(9): 537-52, Sep 2015.

Oyama Mark A: Perioperative Monitoring of Heart Rate and Rhythm. The Veterinary clinics of North America. Small animal practice 45(5): 953-63, Sep 2015.

Oyama Mark A: Using Cardiac Biomarkers in Veterinary Practice. Clinics in laboratory medicine 35(3): 555-66, Sep 2015.

Cremer S E, Moesgaard S G, Rasmussen C E, Zois N E, Falk T, Reimann M J, Cirera S, Aupperle H, Oyama M A, Olsen L H: Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease. Research in veterinary science 100: 197-206, Jun 2015.

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Last updated: 03/01/2022
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