Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

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Description of CVI Expertise

CVI Program Unit(s):
Myocyte Biology / Heart Failure
Pulmonary Vascular Disease

CVI Research Description:
My laboratory is investigating signaling mechanisms of pulmonary vascular smooth muscle cell proliferation and migration as it relates to pulmonary arterial hypertension (PAH). mTOR signaling modulates metabolic deregulationin in vascular smooth muscle in PAH; discovery of novel signaling network in VSM remodeling

Selected Publications

Elena A. Goncharova, Dmitry A. Goncharov, Melane L. James, Elena N. Atochina-Vasserman, Seung-Beom Hong, Hua Li, Linda Gonzales, Masaya Baba, W. Marston Linehan, Susan Margulies, Susan Guttentag, Laura S. Schmidt, and Vera P. Krymskaya : Folliculin Controls Lung Alveolar Enlargement and Epithelial Cell Survival through E-Cadherin, LKB1 and AMPK Cell Reports 7: 412-423, April 2014 Notes: Highlighted in Cell Reports.

Elena A. Goncharova, Dmitry A. Goncharov, Melane Fehrenbach, Irene Khavin, Blerina Ducka, Okio Hino, Thomas V. Colby, Mervyn J. Merrilees, Angela Haczku, Steven M. Albelda, and Vera P. Krymskaya: Prevention of Alveolar Destruction and Airspace Enlargement in a Mouse Model of Pulmonary Lymphangioleiomyomatosis (LAM). Science Translational Medicine 4(154): 154ra134, October 2012 Notes: cited by F1000Prime.

Goncharova EA, Goncharov DA, Li H, Pimtong W, Lu S, Khavin I, Krymskaya VP: mTORC2 is required for proliferation and survival of TSC2-null cells Molecular and Cellular Biology 31: 2484-2498, March 2011.

Dmitry A. Goncharov, Tatiana Kudryashova, Houman Ziai, Kaori Ihida-Stansbury, Horace DeLisser1,3, Vera P. Krymskaya, Rubin M. Tuder, Steven M. Kawut, Elena A. Goncharova: mTORC2 coordinates pulmonary artery smooth muscle cell metabolism, proliferation and survival in pulmonary arterial hypertension. Circulation 129: 864-874, February 2014.

Elena A. Goncharova, Dmitry A. Goncharov, and Vera P. Krymskaya: Tumor suppressors TSC1 and TSC2 differentially modulate actin cytoskeleton and motility of mouse embryonic fibroblasts. The LAM Foundation 17th Annual International Conference Page: 48, April 2014 Notes: Poster Presentation.

Atochina-Vasserman EN, Guo CJ, Abramova E, Golden TN, Sims M, James ML, Beers MF, Gow AJ, Krymskaya VP: Surfactant Dysfunction and Lung Inflammation in the Female Mouse Model of Lymphangioleiomyomatosis. American Journal of Respiratory Cell and Molecular Biology 53(1): 96-104, July 2015 Notes: Higlighted paper in the Red Alert.

Goncharova EA, Goncharov DA, Noonan D, Krymskaya VP: TSC2 modulates actin cytoskeleton and cell adhesion through TSC1-binding domain and Rac1 GTPase. Journal of Cell Biology 167: 1171-1182, 2004 Notes: Highlighted in Nat. Cell Biol.

Goncharova EA, Goncharov DA, Eszterhas A, Hunter DS, Glassberg MK, Yeung RS, Walker CL, Noonan D, Kwiatkowski DJ, Chou MM, Panettieri Jr RA, Krymskaya VP: Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). Journal of Biological Chemistry 277(34): 30958-67, Aug 23 2002 Notes: Cited in Nat. Cell Biol.

Stephen R. Hammes and Vera P. Krymskaya : Targeted Approaches Toward Understanding and Treating Pulmonary Lymphangioleiomyomatosis (LAM). Hormones and Cancer 4(2), April 2013.

Vera P. Krymskaya: Therapeutic Strategies for Treatment of Pulmonary Lymphangioleiomyomatosis (LAM). Expert Opinion on Orphan Drugs 2(10): 1063-1074, August 2014.

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Last updated: 09/29/2015
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