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Description of Research Expertise

Basic and translational research in rare and common lung diseases: pulmonary lymphangioleiomyomatosis (LAM), tuberous sclerosis (TS), Birt-Hogg-Dube (BHD); Multicentric Castleman Disease (MCD), pulmonary arterial hypertension (PAH), asthma; Cellular signaling networks: phosphatidylinositol 3-kinase (PI3K), Akt, tumor suppressor complex TSC1/TSC2, protein translational regulation, mTOR,LKB1, AMPK, FLCN, RhoA GTPase, Rac1 GTPase, STAT3; Airway smooth muscle cell biology and remodeling,vascular smooth muscle cell biology and remodeling, cell growth, cell proliferation, cell migration, invasiveness; animal models of lung diseases.

Description of Clinical Expertise

Principal Investigator of the SOS (Safety Study of Simvastatin in Patients with Sporadic Pulmonary Lymphangioleiomyomatosis (LAM) and LAM Associated with Tuberous Sclerosis Complex) clinical trial (ClinicalTrials.gov Identifier: NCT02061397)

Description of Other Expertise

Marketing management, concert piano

Selected Publications

Obraztsova K, Mukhitov AR, Lin SM, Smith C, Basil MC, Katzen J, Carl J, Beers MF, Morrisey EE, Krymskaya VP: Upregulation of WNT signaling in lung epithelial-mesenchymal crosstalk may contribute to the cystic remodeling in Pulmonary Lymphangioleiomyomatosis(LAM). American Thoracic Society. American Thoracic Society, May 2021 Notes: Submitted for presentation at American Thoracic Society International Conference in May 2021.

Kovalenko A, Sanin A, Kosmas K, Zhang L, Wang J, Akl EW, Giannikou K, Probst CK, Hougard TR, Rue RW, Krymskaya VP, Asara JM, Lam HC, Kwiatkowski DJ, Henske EP, Filippakis H: Therapeutic targeting of DGKA-mediated macropinocytosis leads to phospholipid reprogramming in Tuberous Sclerosis Complex. Cancer Research 81: 2086-2100, April 2021 Notes: DOI: 10.1158/0008-5472.CAN-20-2218.

Evans JF, Obraztsova K, Lin SM, Krymskaya VP : CrossTORC and Wntegration in disease: Focus on Lymphangioleiomyomatosis. International Journal of Molecular Sciences 22: 2233-2248, February 2021 Notes: doi.org/10.3390/ijms22052233.

Obraztsova K, Basil MC, Rue R, Sivakumar A, Lin SM, Mukhitov AR, Gritsiuta AI, Evans JF, Kopp M, Katzen J, Robichaud A, Atochina-Vasserman EN, Li S, Carl J, Babu A, Morley MP, Cantu E, Beers MF, Frank DB, Morrisey EE, Krymskaya VP: mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline. Nature Communications 11(1): 5640, Nov 2020 Notes: https://doi.org/10.1038/s41467-020-18979-4.

Li H, Oh HB, Viollet B, Schmidt LS, Linehan WM, Krymskaya VP, Hong SB: Requirement of FLCN tumor suppressor gene for mTORC1-mediated inhibition of TFE3 transcriptional activity. bioRxiv Jul 2020 Notes: doi: https://doi.org/10.1101/2020.07.08.193169.

Han F, Dellacecca ER, Barse LW, Cosgrove C, Henning SW, Ankney CM, Jaishankar D, Yemelyanov A, Krymskaya VP, Dilling DF, Le Poole IC: Adoptive T cell transfer to treat lymphangioleiomyomatosis. American Journal of Respiratory Cell and Molecular Biology 62(6): 793-804, Jun 2020 Notes: doi: 10.1165/rcmb.2019-0117OC.

Obraztsova K, Mukhitov A, Basil MC, Katzen J, Carl J, Beers MF, Morrisey EE, Krymskaya VP: Abnormal alveolar architecture in lymphangioleiomymatosis (LAM) lungs is a result of defective epithelial-mesenchymal crosstalk. American Thoracic Society May 2020 Notes: Submitted to American Thoracic Society International Conference, May 2020, Philadelphia, PA.

Krymskaya VP, Courtwright AM, Fleck V, Dorgan D, Kotloff R, McCormack FX, Kreider M: A phase II clinical trial of the Safety Of Simvastatin (SOS) in patients with pulmonary lymphangioleiomyomatosis and with tuberous sclerosis complex. Respiratory Medicine 163: 105898, Mar 2020 Notes: doi: 10.1016/j.rmed.2020.105898.

Evans JF, Rue RW, Mukhitov AR, Obraztsova K, Smith CJ, Krymskaya VP : Inhibition of growth of TSC2-null cells by a PI3K/mTOR inhibitor but not by a selective MNK1/2 inhibitor Biomolecules: Molecular Pathology, Molecular Mechanisms of Lung Diseases 10(1): 28, Dec 2019 Notes: doi: 10.3390/biom10010028.

Krymskaya VP, McCormack FX: Lymphangioleiomyomatosis: a monogenic model of malignancy. Annual Review of Medicine 68: 69-83, Jan 2017 Notes: NIHMSID: 889033.

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Last updated: 04/16/2021
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