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Wei Tong, PhD

Associate Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
310D Abramson Research Center
The Children’s Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-426-0930
Fax: 267-426-5476
Lab: 267-426-0870
Education:
BS (Molecular and cellular biology)
University of Science and Technology of China, 1994.
PhD (Developmental and molecular biology)
Albert Einstein College of Medicine, 2000.
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Description of CVI Expertise

CVI Program Unit(s):
Thrombosis / Hemostasis

CVI Research Description:
The amplitude and duration of cytokine receptor signaling is a highly regulated process that is crucial for cytokine- governed hematopoiesis. Dysregulation of these complex signaling networks can predispose to myeloproliferative diseases and leukemia.

My laboratory is interested in cytokine receptor signaling in hematopoietic stem / progenitor cell expansion and differentiation. In particular, we focus on understanding the molecular mechanisms by which the adaptor protein, Lnk, regulates thrombopoietin (TPO) receptor and Janus kinase (JAK2) signaling in megakaryopoiesis and hematopoietic stem cell self-renewal. In addition, we are interested in investigating oncogenic cytokine receptor signaling processes that control hematopoietic stem and progenitor cell transformation.

Selected Publications

Lv Kaosheng, Jiang Jing, Donaghy Ryan, Riling Christopher R, Cheng Ying, Chandra Vemika, Rozenova Krasimira, An Wei, Mohapatra Bhopal C, Goetz Benjamin T, Pillai Vinodh, Han Xu, Todd Emily A, Jeschke Grace R, Langdon Wallace Y, Kumar Suresh, Hexner Elizabeth O, Band Hamid, Tong Wei: CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies. Genes & development 31(10): 1007-1023, May 2017.

Giani Felix C, Fiorini Claudia, Wakabayashi Aoi, Ludwig Leif S, Salem Rany M, Jobaliya Chintan D, Regan Stephanie N, Ulirsch Jacob C, Liang Ge, Steinberg-Shemer Orna, Guo Michael H, Esko Tõnu, Tong Wei, Brugnara Carlo, Hirschhorn Joel N, Weiss Mitchell J, Zon Leonard I, Chou Stella T, French Deborah L, Musunuru Kiran, Sankaran Vijay G: Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells. Cell stem cell 18(1): 73-8, Jan 2016.

Cheng Ying, Chikwava Kudakwashe, Wu Chao, Zhang Haibing, Bhagat Anchit, Pei Dehua, Choi John K, Tong Wei: LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors. The Journal of clinical investigation 126(4): 1267-81, Apr 2016.

Jiang Qinqin, Paramasivam Manikandan, Aressy Bernadette, Wu Junmin, Bellani Marina, Tong Wei, Seidman Michael M, Greenberg Roger A: MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links. Genes & development 29(18): 1955-68, Sep 2015.

Rozenova Krasimira, Jiang Jing, Donaghy Ryan, Aressy Bernadette, Greenberg Roger A, Tong Wei: MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling. Blood 125(11): 1730-8, Mar 2015.

Jiang Jing, Balcerek Joanna, Rozenova Krasimira, Cheng Ying, Bersenev Alexey, Wu Chao, Song Yiwen, Tong Wei: 14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells. The Journal of clinical investigation 122(6): 2079-91, Jun 2012.

Bersenev Alexey, Rozenova Krasimira, Balcerek Joanna, Jiang Jing, Wu Chao, Tong Wei: Lnk deficiency partially mitigates hematopoietic stem cell aging. Aging cell 11(6): 949-59, Dec 2012.

Bersenev Alexey, Wu Chao, Balcerek Joanna, Jing Jiang, Kundu Mondira, Blobel Gerd A, Chikwava Kudakwashe R, Tong Wei: Lnk constrains myeloproliferative diseases in mice. The Journal of clinical investigation 120(6): 2058-69, Jun 2010.

Huang Jian, Zhang Yi, Bersenev Alexey, O'Brien W Timothy, Tong Wei, Emerson Stephen G, Klein Peter S: Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice. The Journal of clinical investigation 119(12): 3519-29, Dec 2009.

Scott Linda M, Tong Wei, Levine Ross L, Scott Mike A, Beer Philip A, Stratton Michael R, Futreal P Andrew, Erber Wendy N, McMullin Mary Frances, Harrison Claire N, Warren Alan J, Gilliland D Gary, Lodish Harvey F, Green Anthony R: JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. The New England journal of medicine 356(5): 459-68, Feb 2007.

Bersenev Alexey, Wu Chao, Balcerek Joanna, Tong Wei: Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2. The Journal of clinical investigation 118(8): 2832-44, Aug 2008.

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Last updated: 07/29/2017
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