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George Scott Worthen, M.D.

Professor of Pediatrics
Department: Pediatrics

Contact information
Abramson Research Center, 416H
Children's Hospital of Philadelphia
3516 Civic Center Boulevard
Philadelphia, PA 19104-4318
Office: 215-590-5455
Education:
AB (History & Science)
Harvard College, 1973.
MD (Medicine)
Harvard Medical School, 1977.
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Description of CVI Expertise

CVI Program Unit(s):
Myocyte Biology / Heart Failure

CVI Research Description:
As of summer 2007, I have recently arrived at Children's Hospital of Philadelphia (CHOP), having moved from University of Colorado Health Sciences Center of Denver where I was an adult lung disease physician at National Jewish.

I was recruited to CHOP to contribute to the Joseph Stokes Jr. Research Institute's Neonatology Division Research portfolio in the area of lung injury, since my lab has focused on lung inflammation for many years.

We have recently made a knockout of an interesting chemokine, CXCL5, which appears to be expressed in resident cells of the lung heart, and gut (rather than myeloid/DC cells that have taken up residence). It appears that certain inflamatory responses in the lung are attenuated in this mouse, despite the considerable redundancy of chemokine expression. We are interested in the possibility that expression of CXC chemokines by the heart in response to ischemia-reperfusion or infarction contributes to myocardial dysfunction, infarct extension, and remodeling.

We would like to find a group with which to work on this problem - applying insights on neutrophil recruitment to the ischemic heart.

Selected Publications

Laudanski K, Qing M, Oszkiel H, Zawadka M, Lapko N, Nowak Z, Worthen GS, Sullivan, K: Long-term monocyte dysfunction after sepsis in humanized mice is related to persisted activation of M-CSF and demethylation of PU.1 and it can be reversed by blocking M-CSF in vitro or by transplanting autologous stem cells in vivo. Frontiers in Immunol 2017 [in press]

Gray J, Oherle K, Wood J, Worthen GS, Ouyang, W, Alenghat T, Whitsett J, Deshmukh H: Commensal Bacteria direct the development of lung immunity in the neonate. Science Translational Medicine 2017 [in press]

Chapman DG, Mougey EB, Van der Velden JL, Lahue KG, Aliyeva M, Daphtary N, George KL, Hoffman SM, Schneider RW, Tracy RP, Worthen GS, Poynter ME, Peters SP, Lima JJ, Janssen-Heininger YM, Irvin CG : The Duffy Antigen Receptor for Chemokines (DARC) regulates asthma pathophysiology. Clin Exp Allergy May 2017 [Epub ahead of print] Notes: doi: 10.1111/cea.12949.

Guo L, Feng K, Wang YC, Mei JJ, Ning RT, Zheng HW, Wang JJ, Worthen GS, Wang X, Song J, Li QH, Liu LD: Critical role of CXCL4 in the lung pathogenesis of influenza (H1N1) respiratory infection. Mucosal Immunol Jan 2017 [Epub ahead of print] Notes: doi: 10.1038/mi.2017.1.

Bdeir K, Gollomp K, Stasiak M, Mei J, Papiewska-Pajak I, Zhao G, Worthen GS, Cines DB, Poncz M, Kowalska MA: Platelet-specific chemokines contribute to the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol 56(2): 261-270, Feb 2017.

Paris AJ, Liu Y, Mei J, Dai N, Guo L, Spruce LA, Hudock KM, Brenner JS, Zacharias WJ, Mei HD, Slamowitz AR, Bhamidipati K, Beers MF, Seeholzer SH, Morrisey EE, Worthen GS: Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol 311(6): L1062-L1075, Dec 2016.

Avgousti DC, Hermann C, Kulej K, Pancholi NJ, Sekulic N, Petrescu J, Molden RC, Blumenthal D, Paris AJ, Reyes ED, Ostapchuk P, Hearing P, Seeholzer SH, Worthen GS, Black BE, Garcia BA, Weitzman MD: A core viral protein binds host nucleosomes to sequester immune danger signals. Nature 535(7610): 173-177, Jul 2016.

Laudanski K, Qing M, Oszkiel H, Zawadka M, Lapko N, Nowak Z, Worthen GS: Ketamine affects in vitro differentiation of monocyte into immature dendritic cells. Anesthesiology 123(3): 628-641, Sep 2015.

Liu Y, O'Leary CE, Wang L-CS, Bhatti TR, Dai N, Kapoor V, Liu P, Mei JJ, Guo L, Oliver PM, Albelda SM, Worthen GS: CD11b+Ly6G+ cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis. Oncoimmunology 5(1): e1061175, Jul 2015.

Qing DY, Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS: Red blood cells induce necroptosis of lung endothelial cells and increase susceptibility to lung inflammation. Am J Respir Crit Care Med 190(11): 1243-1254, Dec 2014.

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Last updated: 05/08/2017
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