George Scott Worthen, M.D.

faculty photo
Professor of Pediatrics
Department: Pediatrics

Contact information
Abramson Research Center, 416H
Children's Hospital of Philadelphia
3516 Civic Center Boulevard
Philadelphia, PA 19104-4318
Office: 215-590-5455
Education:
AB (History & Science)
Harvard College, 1973.
MD (Medicine)
Harvard Medical School, 1977.
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Selected Publications

Bellissimo DC, Chen CH, Zhu Q, Bagga S, Lee CT, He B, Wertheim GB, Jordan M, Tan K, Worthen GS, Gilliland DG, Speck NA: Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling. Blood Adv. 24(6): 1145-115, 2020.

Paris, AJ, Oved, JH, Wang, P, Dai, N, Worthen, GS: Neutrophils degrade nucleic acids to improve lung repair after injury. Blood 2020 Notes: In review.

Dimitra Kokkinaki, Sophia Murphy, Alessandro Venosa, Scott Sherrill-Mix, Meghan J. Hotz, Carla Casu, Peggy Zhang, Dorothy E. Loy, Caroline A.G. Ittner, Nuala J. Meyer, Stefano Rivella, Beatrice H. Hahn, G. Scott Worthen, Nilam S. Mangalmurti.: Cell free DNA drives inflammatory anemia via TLR9 by masking the marker of self CD47 on red blood cells. Science 2020 Notes: In review.

Paris, AJ, Hayer, KE, Oved, JH, Avgousti, DC, Toulmin, SA, Zepp, JA, Zacharias, WJ, Katzen, JB, Basil, MC, Kremp, MM, Slamowitz, AR, Jayachandran,S, Sivakumar,A, Wang, P, Dai, N, Frank, DB, Eisenlohr, LC, Cantu, E, Beers, MF, Weitzman, MD, Morissey, EE, Worthen, GS.: Stat3-Bdnf-TrkB signaling promotes alveolar regeneration. Nature Cell Biology 2020 Notes: In Press.

Hudock KM, Collins MS, Imbrogno M, Snowball J, Kramer EL, Brewington JJ, Gollomp K, McCarthy C, Ostmann AJ, Kopras EJ, Davidson CR, Srdiharan A, Arumugam P, Sengupta S, Xu Y, Worthen GS, Trapnell BC, Clancy JP: Neutrophil extracellular traps activate IL-8 and IL-1 expression in human bronchial epithelia. Am J Physiol Lung Cell Mol Physiol. 2020 Notes: In Press.

Liu Y, Perego M, Xiao Q, He Y, Fu S, He J, Liu W, Li X, Tang Y, Li X, Yuan W, Zhou W, Wu F, Jia C, Cui Q, Worthen GS, Jensen EA, Gabrilovich DI, Zhou J.: Lactoferrin-induced myeloid-derived suppressor cell therapy attenuates pathologic inflammatory conditions in newborn mice. J Clin Invest. 129(10): 4261-4275, 2019.

Lubkin A, Lee WL, Alonzo F 3rd, Wang C, Aligo J, Keller M, Girgis NM, Reyes- Robles T, Chan R, O'Malley A, Buckley P, Vozhilla N, Vasquez MT, Su J, Sugiyama M, Yeung ST, Coffre M, Bajwa S, Chen E, Martin P, Kim SY, Loomis C, Worthen GS, Shopsin B, Khanna KM, Weinstock D, Lynch AS, Koralov SB, Loke P, Cadwell K, Torres VJ.: Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice. Cell Host Microbe 25(3): 463-470, 2019.

Paris AJ, Guo L, Dai N, Katzen JB, Patel PN, Worthen GS, Brenner J: Using selective lung injury to improve murine models of spatially heterogeneous lung diseases. PLoS One 14(4): e0202456, 2019.

Hotz MJ, Qing D, Shashaty MGS, Zhang P, Faust H, Sondheimer N, Rivella S, Worthen GS, Mangalmurti NS.: Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury. Am J Respir Crit Care Med. Am J Respir Crit Care Med 197(4): 470-480, 2018.

Guo L, Feng K, Wang YC, Mei JJ, Ning RT, Zheng HW, Wang JJ, Worthen GS, Wang X, Song J, Li QH, Liu LD: Critical role of CXCL4 in the lung pathogenesis of influenza (H1N1) respiratory infection. Mucosal Immunol 10(6): 1529-1541, Nov 2017 Notes: doi: 10.1038/mi.2017.1.

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Last updated: 06/11/2020
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