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David F. Wilson, PhD

Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics
Graduate Group Affiliations

Contact information
901A Stellar-Chance Laboratories
Philadelphia, PA 19104-6059
Office: (215) 898-6382
Fax: (215) 573-3787
Education:
B.S.
Colorado State University, Fort Collins, Colorado , 1959.
Ph.D.
Oregon State University, 1964.
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Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Biotechnology / Nanomedicine / Imaging

CVI Research Description:
Our research interest is in oxygen delivery to tissue and the role of oxygen in tissue physiology, biochemistry and pathology. Most of our work in recent years has been on hypoxic/ischemic injury to the newborn brain and the role of oxygen in tumor physiology and therapy, but we have long been also interested in the heart.

In pursuing our interests in the role of oxygen in tissue, we have developed an optical method for quantitative measurement, including imaging, in living tissue and in real time. This method uses specially constructed phosphorescent nanosensors to detect and measure oxygen. We are continuing development of this technology both for use in basic research and for possible translation into the clinics.

Selected Publications

Wilson David F: Programming and regulation of metabolic homeostasis. American journal of physiology. Endocrinology and metabolism 308(6): E506-17, Mar 2015.

Wilson David F, Harrison David K, Vinogradov Andrei: Mitochondrial cytochrome c oxidase and control of energy metabolism: measurements in suspensions of isolated mitochondria. Journal of applied physiology (Bethesda, Md. : 1985) 117(12): 1424-30, Dec 2014.

Wilson David F, Vinogradov Sergei A: Mitochondrial cytochrome c oxidase: mechanism of action and role in regulating oxidative phosphorylation. Journal of applied physiology (Bethesda, Md. : 1985) 117(12): 1431-9, Dec 2014.

Pastuszko Peter, Schears Gregory J, Greeley William J, Kubin Joanna, Wilson David F, Pastuszko Anna: Granulocyte colony stimulating factor reduces brain injury in a cardiopulmonary bypass-circulatory arrest model of ischemia in a newborn piglet. Neurochemical research 39(11): 2085-92, Nov 2014.

Wilson David F: Regulation of cellular metabolism: programming and maintaining metabolic homeostasis. Journal of applied physiology (Bethesda, Md. : 1985) 115(11): 1583-8, Dec 2013.

Yu J, Ramadeen A, Tsui A K Y, Hu X, Zou L, Wilson D F, Esipova T V, Vinogradov S A, Leong-Poi H, Zamiri N, Mazer C D, Dorian P, Hare G M T: Quantitative assessment of brain microvascular and tissue oxygenation during cardiac arrest and resuscitation in pigs. Anaesthesia 68(7): 723-35, Jul 2013.

Hu Tina, Beattie W Scott, Mazer C David, Leong-Poi Howard, Fujii Hiroko, Wilson David F, Tsui Albert K Y, Liu Elaine, Muhammad Maimoona, Baker Andrew J, Hare Gregory M T: Treatment with a highly selective β₁ antagonist causes dose-dependent impairment of cerebral perfusion after hemodilution in rats. Anesthesia and analgesia 116(3): 649-62, Mar 2013.

Wilson David F, Harrison David K: Simultaneous monitoring of brain and skin oxygenation during haemorrhagic shock in piglets. Advances in experimental medicine and biology 789: 51-7, 2013.

Wilson David F, Harrison David K, Vinogradov Sergei A: Oxygen, pH, and mitochondrial oxidative phosphorylation. Journal of applied physiology (Bethesda, Md. : 1985) 113(12): 1838-45, Dec 2012.

Pastuszko, Peter. Schears, Gregory J. Pirzadeh, Afsaneh. Kubin, Joanna. Greeley, William J. Wilson, David F. Pastuszko, Anna.: Effect of granulocyte-colony stimulating factor on expression of selected proteins involved in regulation of apoptosis in the brain of newborn piglets after cardiopulmonary bypass and deep hypothermic circulatory arrest. Journal of Thoracic & Cardiovascular Surgery 143(6): 1436-42, Jun 2012.

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Last updated: 04/23/2007
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