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David F. Wilson, PhD

Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics
Graduate Group Affiliations

Contact information
901A Stellar-Chance Laboratories
Philadelphia, PA 19104-6059
Office: (215) 898-6382
Fax: (215) 573-3787
Education:
B.S.
Colorado State University, Fort Collins, Colorado , 1959.
Ph.D.
Oregon State University, 1964.
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Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Biotechnology / Nanomedicine / Imaging

CVI Research Description:
Our research interest is in oxygen delivery to tissue and the role of oxygen in tissue physiology, biochemistry and pathology. Most of our work in recent years has been on hypoxic/ischemic injury to the newborn brain and the role of oxygen in tumor physiology and therapy, but we have long been also interested in the heart.

In pursuing our interests in the role of oxygen in tissue, we have developed an optical method for quantitative measurement, including imaging, in living tissue and in real time. This method uses specially constructed phosphorescent nanosensors to detect and measure oxygen. We are continuing development of this technology both for use in basic research and for possible translation into the clinics.

Selected Publications

Wilson DF, Cember ATJ, Matschinsky FM: Glutamate dehydrogenase: Role in regulating metabolism and insulin release in pancreatic β-cells. J Appl Physiol (1985). 2018 Apr 12. doi: 10.1152/japplphysiol.01077.2017 April 2018.

Wilson DF: Oxidative phosphorylation: regulation and role in cellular and tissue metabolism. J Physiol. 2017 Dec 1;595(23):7023-7038. doi: 10.1113/JP273839. Epub 2017 Oct 29 595(23), Dec 2017.

Pastuszko P, Schears GJ, Kubin J, Wilson DF, Pastuszko A.: Granulocyte colony-stimulating factor significantly decreases density of hippocampal caspase 3-positive nuclei, thus ameliorating apoptosis-mediated damage, in a model of ischaemic neonatal brain injury. Interact Cardiovasc Thorac Surg. 2017 Oct 1;25(4):600-605. doi: 10.1093/icvts/ivx047 25(4): 600-605, October 2017.

Wilson DF, Cember ATJ, Matschinsky FM: The thermodynamic basis of glucose-stimulated insulin release: a model of the core mechanism. Physiol Rep. 2017 Jun;5(12). pii: e13327. doi: 10.14814/phy2.13327 5(12), June 2017.

Wilson DF: Oxidative phosphorylation: unique regulatory mechanism and role in metabolic homeostasis. J Appl Physiol (1985). 2017 Mar 1;122(3):611-619. doi: 10.1152/japplphysiol.00715.2016. Epub 2016 Oct 27 122(3): 611-619, March 2017.

Kei T, Mistry N, Tsui AKY, Liu E, Rogers S, Doctor A, Wilson DF, Desjardins JF, Connelly K, Mazer CD, Hare GMT: Experimental assessment of oxygen homeostasis during acute hemodilution: the integrated role of hemoglobin concentration and blood pressure. Intensive Care Med Exp. 2017 Dec;5(1):12. doi: 10.1186/s40635-017-0125-6. Epub 2017 Mar 1 5(1), March 2017.

Wilson DF: Regulation of metabolism: the work-to-rest transition in skeletal muscle. Am J Physiol Endocrinol Metab. 2016 Apr 15;310(8):E633-E642. doi: 10.1152/ajpendo.00512.2015. Epub 2016 Feb 2 310(8): E633-E642, April 2016.

Wilson DF: Regulation of metabolism: the rest-to-work transition in skeletal muscle. Am J Physiol Endocrinol Metab. 2015 Nov 1;309(9):E793-801. doi: 10.1152/ajpendo.00355.2015. Epub 2015 Sep 22. 309(9): E793-E801, September 2015.

Wilson David F: Programming and regulation of metabolic homeostasis. American journal of physiology. Endocrinology and metabolism 308(6): E506-17, Mar 2015.

Wilson David F, Harrison David K, Vinogradov Andrei: Mitochondrial cytochrome c oxidase and control of energy metabolism: measurements in suspensions of isolated mitochondria. Journal of applied physiology (Bethesda, Md. : 1985) 117(12): 1424-30, Dec 2014.

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Last updated: 06/13/2018
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